Results 51 to 60 of about 5,959,101 (252)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Development of a stream DTM generation method using vegetation and morphology composite filters with SfM point clouds

Scientific Reports
Developing method for generating accurate Digital Terrain Model (DTM) of streams is necessary due to the limitations of traditional field survey methods, which are time-consuming and costly and do not provide continuous data.
Hyeokjin Lee, Jaejun Gou, Jinseok Park, Seongju Jang, Inhong Song   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Enhancing attention and emotion regulation in children with ADHD through AR digital picture books: a structural equation modeling approach

Frontiers in Psychology
This study investigates the effectiveness of augmented reality (AR) digital picture books in improving attention and emotional regulation among children with Attention Deficit Hyperactivity Disorder (ADHD).
Rongming Yang, Weibo Sun, Xinwei Liu, Yuanfang Cao   +3 more
doaj   +1 more source

Mobility, Internationalisation, Higher Education: European Challenges

, 2014
With an increase in global competition among universities and national higher education systems, educational programs desire to offer compatible content without losing their competitive advantage.
Maria da Conceição Pereira Ramos
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Market-Driven Management, Global Markets and Competitive Convergence [PDF]

Global markets redefine competition space, fostering a collaborative network between companies (market-driven management). Globalisation it causes previously distinct global economies to converge into a single large market, thus generating fusion between
Elisa Rancati
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Development of a stream DTM generation methodology using UAV-based SfM and LiDAR point cloud

Scientific Reports
Filtering ground points and generating accurate Digital Terrain Models (DTMs) are crucial for hydrological and ecological modeling in riverine environments.
Jaejun Gou, Hyeokjin Lee, Jinseok Park, Seongju Jang, Nakyung Lee, Inhong Song   +5 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source