Results 41 to 50 of about 1,236,686 (282)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Nonintrusive coupling of 3D and 2D laminated composite models based on finite element 3D recovery

, 2014
In order to simulate the mechanical behavior of large structures assembled from thin composite panels, we propose a coupling technique which substitutes local 3D models for the global plate model in the critical zones where plate modeling is inadequate ...
Allix, Olivier, Gosselet, Pierre, Guguin, Guillaume, Guinard, Stéphane   +3 more
core   +2 more sources

Global and Quadratic Convergence of Newton Hard-Thresholding Pursuit [PDF]

, 2020
Algorithms based on the hard thresholding principle have been well studied with sounding theoretical guarantees in the compressed sensing and more general sparsity-constrained optimization.
Qi, Hou-Duo, Xiu, Naihua, Zhou, Shenglong   +2 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Metaverse? No, thanks! Exploring the mechanisms behind Generation Z’s resistance behavior

Frontiers in Psychology
The metaverse is progressively advancing toward broad application in real-world scenarios. However, as a key driving force of today’s digital economy, Generation Z has not demonstrated sufficient enthusiasm for participation.
Ning Ding, Liling Hu, Qin Zhao, Kyung-Tae Kim, Maowei Chen   +4 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Linear convergence of the generalized Douglas-Rachford algorithm for feasibility problems

, 2018
In this paper, we study the generalized Douglas-Rachford algorithm and its cyclic variants which include many projection-type methods such as the classical Douglas-Rachford algorithm and the alternating projection algorithm.
Dao, Minh N., Phan, Hung M.
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Estimation of 1-Repetition Maximum Using a Hydraulic Bench Press Machine Based on User’s Lifting Speed and Load Weight

Sensors, 2022
1-repetition maximum (1RM), a representative index for an individual’s weightlifting capacity, provides an organized workout guide, but to measure 1RM needs several repetitive exercises up to one’s limit and has a risk of injury, thus, not adequate for ...
Jinyeol Yoo, Jihun Kim, Byunggon Hwang, Gyuseok Shim, Jaehyo Kim   +4 more
doaj   +1 more source

Global exponential convergence to variational traveling waves in cylinders

, 2011
We prove, under generic assumptions, that the special variational traveling wave that minimizes the exponentially weighted Ginzburg-Landau functional associated with scalar reaction-diffusion equations in infinite cylinders is the long-time attractor for
Barenblatt G. I., Berestycki H., C. B. Muratov, Gallay T., Gallay T., Kanel' Y. I., Kanel' Y. I., Kolmogorov A. N., Lions P.-L., M. Novaga, Uchiyama K.   +10 more
core   +1 more source