Results 41 to 50 of about 225,788 (313)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Role of Gamification in Undergraduate Student Retention: A Sustainability Approach Using an Extension of the Technology Acceptance Model (TAM)

Human Behavior and Emerging Technologies
Student retention remains a persistent challenge in higher education. This has led institutions to explore innovative pedagogical approaches that boost student engagement and sustained academic participation.
Hayder Albayati, Aradhana Singh
doaj   +1 more source

Predicting susceptibility to landslides under climate change impacts in metropolitan areas of South Korea using machine learning

Geomatics, Natural Hazards & Risk, 2021
Landslides cause considerable damage to life and property worldwide. In order to prevent and respond to landslides, it is necessary to identify vulnerable areas. This study identified areas that are likely to be damaged by landslides and aimed to predict
Sang-Jin Park, Dong-kun Lee
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Factors influencing digital media designers’ subscription to premium versions of AI drawing tools through a mixed methods study

Scientific Reports
With the continuous advancement of artificial intelligence (AI) technology—particularly the widespread adoption of generative AI—the application of AI tools in the design field has become increasingly prevalent, demonstrating considerable potential for ...
Liling Hu, Maowei Chen, Ning Ding
doaj   +1 more source

MST-VAE: Multi-Scale Temporal Variational Autoencoder for Anomaly Detection in Multivariate Time Series

Applied Sciences, 2022
In IT monitoring systems, anomaly detection plays a vital role in detecting and alerting unexpected behaviors timely to system operators. With the growth of signal data in both volumes and dimensions during operation, unsupervised learning turns out to ...
Tuan-Anh Pham, Jong-Hoon Lee, Choong-Shik Park   +2 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

A Globally Convergent LP-Newton Method

SIAM Journal on Optimization, 2016
Summary: We develop a globally convergent algorithm based on the LP-Newton method, which has been recently proposed for solving constrained equations, possibly nonsmooth and possibly with nonisolated solutions. The new algorithm makes use of linesearch for the natural merit function and preserves the strong local convergence properties of the original ...
Andreas Fischer 0004, Markus Herrich, Alexey F. Izmailov, Mikhail V. Solodov   +3 more
openaire   +4 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source