Results 141 to 150 of about 2,416,289 (329)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

An Improved Copula‐Based Framework for Efficient Global Sensitivity Analysis

Water Resources Research
Global sensitivity analysis (GSA) enhances our understanding of computational models and simplifies model parameter estimation. VarIance‐based Sensitivity analysis using COpUlaS (VISCOUS) is a variance‐based GSA framework.
Hongli Liu, Martyn P. Clark, Shervan Gharari, Razi Sheikholeslami, Jim Freer, Wouter J. M. Knoben, Christopher B. Marsh, Simon Michael Papalexiou   +7 more
doaj   +1 more source

Global Sensitivity Analysis of Background Life Cycle Inventories. [PDF]

Environ Sci Technol, 2022
Kim A, Mutel CL, Froemelt A, Hellweg S.
europepmc   +1 more source

Non-parametric methods for global sensitivity analysis of model output with dependent inputs

, 2015
Thierry A. Mara, Stefano Tarantola, Paola Annoni   +2 more
openalex   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Analysis of Hepatic Lipid Metabolism Model: Simulation and Non-Stationary Global Sensitivity Analysis. [PDF]

Nutrients, 2022
Kosić M, Benković M, Jurina T, Valinger D, Gajdoš Kljusurić J, Tušek AJ.   +5 more
europepmc   +1 more source

Applying Local and Global Sensitivity Analysis to Inform Bigheaded Carp Management [PDF]

Richard A. Erickson, Benjamin J. Marcek, Hannah M. Thompson, Brian Schoenung, John M. Dettmers, Michael N. Fienen   +5 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Global sensitivity of EEG source analysis to tissue conductivity uncertainties

Frontiers in Human Neuroscience
IntroductionTo reliably solve the EEG inverse problem, accurate EEG forward solutions based on a detailed, individual volume conductor model of the head are essential.
Johannes Vorwerk, Carsten H. Wolters, Carsten H. Wolters, Daniel Baumgarten   +3 more
doaj   +1 more source