Results 71 to 80 of about 829,331 (263)

CoupModel (v6.0): Global parameter sensitivity analysis

, 2020
Global sensitivity analysis of all P and relevant N parameters in CoupModel v. 6.0 (Coup-CNP) Original simulation files including the model set-up, parameterization settings, and corresponding input and validation files, used in the supplement of He, H., Jansson, P.-E., and Gärdenäs, A.: CoupModel (v6.0): an ecosystem model for coupled phosphorus ...
He, Hongxing, Jansson, Per-Erik, Gärdenäs, I. Annemieke   +2 more
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Proportional Marginal Effects for Global Sensitivity Analysis

SIAM/ASA Journal on Uncertainty Quantification
Performing (variance-based) global sensitivity analysis (GSA) with dependent inputs has recently benefited from cooperative game theory concepts.By using this theory, despite the potential correlation between the inputs, meaningful sensitivity indices can be defined via allocation shares of the model output's variance to each input.
Herin, Margot, Il Idrissi, Marouane, Chabridon, Vincent, Iooss, Bertrand   +3 more
openaire   +4 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Making global sensitivity analysis feasible using neural network surrogates

Data-Centric Engineering
How can we make global sensitivity analysis accessible and viable for engineering practice? In this translation article, we present a methodology to enable sensitivity analysis for structural and geotechnical engineering for built environment design and ...
Gihan Weerasinghe, Ramaseshan Kannan, Samila Bandara   +2 more
doaj   +1 more source

Wastewater Stabilisation Ponds System: Global Sensitivity Analysis on Network Design

Chemical Engineering Transactions, 2016
In this work, a wastewater treatment network (WWTN) consisting of a system of ponds is modelled rigorously, taking into account dynamic mass balances for the main groups of bacteria, together with different types of organic load, algae biomass, nutrients,
M.P. Ochoa, V. Estrada, P. Hoch
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Global sensitivity analysis in stability problems of steel frame structures

Journal of Civil Engineering and Management, 2016
Slender steel frame structures are characterised by a number of imperfections which may reduce their load carrying capacity drastically. This article studies the effects of these imperfections on the load carrying capacity of a single storey steel plane ...
Zdeněk Kala
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source