Results 81 to 90 of about 2,317,544 (334)

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Global Sensitivity Analysis of Stochastic Computer Models with joint metamodels [PDF]

, 2009
The global sensitivity analysis method, used to quantify the influence of uncertain input variables on the response variability of a numerical model, is applicable to deterministic computer code (for which the same set of input variables gives always the
Iooss, Bertrand, Marrel, Amandine, Ribatet, Mathieu   +2 more
core   +3 more sources

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

An Inference Method for Global Sensitivity Analysis

Technometrics
Although there is a plethora of methods to estimate sensitivity indices associatedwith individual inputs, there is much less work on interaction effects of every order,especially when it comes to make inferences about the true underlying values ofthe indices.
Gildas Mazo, Laurent Tournier
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Distribution‐Based Global Sensitivity Analysis in Hydrology [PDF]

Water Resources Research, 2019
AbstractGlobal sensitivity analysis (GSA) is routinely used in academic setting to quantify the influence of input variability and uncertainty on predictions of a quantity of interest. Practical applications of GSA are hampered by its high computational cost, which arises from the need to run large (e.g., groundwater) models multiple times, and by its ...
Valentina Ciriello, Ilaria Lauriola, Daniel M. Tartakovsky   +2 more
openaire   +2 more sources

EPS09 - a New Generation of NLO and LO Nuclear Parton Distribution Functions

, 2009
We present a next-to-leading order (NLO) global DGLAP analysis of nuclear parton distribution functions (nPDFs) and their uncertainties. Carrying out an NLO nPDF analysis for the first time with three different types of experimental input -- deep ...
, , , A.D. Martin, C.A Salgado, D. Stump ., H Paukkunen, J. Pumplin ., K.J Eskola, K.J. Eskola, K.J. Eskola, M. Dittmar ., New Muon collaboration, New Muon collaboration, NNPDF collaboration, P.M. Nadolsky, R.K. Ellis, V.N. Gribov, V.N. Gribov, V.N. Gribov, W. Giele ., Y.L. Dokshitzer, Y.L. Dokshitzer, Z.-B. Kang   +23 more
core   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Deep uncertainties in sea-level rise and storm surge projections: Implications for coastal flood risk management

, 2017
Sea-levels are rising in many areas around the world, posing risks to coastal communities and infrastructures. Strategies for managing these flood risks present decision challenges that require a combination of geophysical, economic, and infrastructure ...
Forest, Chris E., Garner, Gregory G., Keller, Klaus, Lee, Ben Seiyon, Oddo, Perry C., Reed, Patrick M., Srikrishnan, Vivek   +6 more
core   +1 more source