Results 111 to 120 of about 3,715,226 (283)
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
A Fujita-type theorem for a multitime evolutionary p-Laplace inequality in the Heisenberg group
Electronic Journal of Differential Equations, 2016 A nonexistence result of global nontrivial positive weak solutions to a multitime evolutionary p-Laplace differential inequality in the Heisenberg group is obtained. Our technique of proof is based on the test function method.
Mohamed Jleli +2 more
doaj
The movement of multidrug-resistant tuberculosis across borders in East Africa needs a regional and global solution. [PDF]
PLoS Med, 2015 Cain KP +9 more
europepmc +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Nonexistence of global solutions for differential inequalities of Sobolev type
Electronic Journal of Differential Equations, 2014 In this article we study three differential inequalities of Sobolev type. Using Pokhozhaev's nonlinear capacity method, we provide sufficient conditions for the nonexistence of global nontrivial weak solutions to these problems.
Mohamed Jleli, Bessem Samet
doaj
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Nonlinear quarter-plane problem for the Korteweg-de Vries equation
Electronic Journal of Differential Equations, 2011 This article concerns an initial-boundary value problem in a quarter-plane for the Korteweg-de Vries (KdV) equation. For general nonlinear boundary conditions we prove the existence and uniqueness of a global regular solution.
Nikolai A. Larkin, Eduardo Tronco
doaj
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source