Results 111 to 120 of about 3,743,687 (283)

Global well-posedness of semilinear hyperbolic equations, parabolic equations and Schrodinger equations

Electronic Journal of Differential Equations, 2018
This article studies the existence and nonexistence of global solutions to the initial boundary value problems for semilinear wave and heat equation, and for Cauchy problem of nonlinear Schrodinger equation.
Runzhang Xu, Yuxuan Chen, Yanbing Yang, Shaohua Chen, Jihong Shen   +4 more
doaj  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Boundedness and global solvability for a chemotaxis-haptotaxis model with p-Laplacian diffusion

Electronic Journal of Differential Equations, 2020
We consider a chemotaxis-haptotaxis system with $p$-Laplacian diffusion in three dimensional bounded domains. It is asserted that for any p>2, under the appropriate assumptions, the chemotaxis-haptotaxis system admits a global bounded weak ...
Changchun Liu, Pingping Li
doaj  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Existence of global solutions for a predator-prey model with cross-diffusion

Electronic Journal of Differential Equations, 2008
In this article, we prove the existence of global classical solutions for a prey-predator model when the space dimension ...
Shenghu Xu
doaj  

Approximation to the global solution of generalized Zakharov equations in R 2. [PDF]

J Inequal Appl, 2018
You S.
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Existence of global solutions for systems of second-order differential equations with p-Laplacian

Electronic Journal of Differential Equations, 2007
We obtain sufficient conditions for the existence of global solutions for the systems of differential equations $$ ig(A(t)Phi_p(y')ig)' + B(t)g(y') + R(t)f(y) = e(t), $$ where $Phi_p(y')$ is the multidimensional p-Laplacian.
Eva Pekarkova, Milan Medved
doaj