Results 51 to 60 of about 746,378 (333)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Arctic dimension of global warming
Лëд и снег, 2015 A brief assessment of the global warming in the Arctic climate system with the emphasis on sea ice is presented. The Arctic region is coupled to the global climate system by the atmosphere and ocean circulation that providesa major contribution to the ...
G. V. Alekseev
doaj +1 more source
Stay healthy under global warming: A review of wearable technology for thermoregulation [PDF]
, 2023 Ronghui Wu +2 more
openalex +1 more source
Evolution of the Dynamic Integrated Climate-Economy (DICE) model : decomposition of changes over time [PDF]
, 2018 Global warming is one of the major environmental challenges of the modern era. Global temperature in 2005 has increased about 0.7°C (1.3°F) compare to 1900, also CO₂ concentrations increased by 100 parts per million (ppm).
Eghtedari Naeini, Milad
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Global warming: preventing irreversibility
Brazilian Journal of Political EconomyThe United Nations Framework Convention on Climate Change met again in Bonn for the COP23 in the fall with Fiji as host, the focus should have been upon the GOAL II in the COP21 Treaty: decarbonisation with 30-40 per cent of 2005 levels until 2030 ...
JAN-ERIK LANE
doaj +1 more source
Environmental Research Letters, 2022 The impacts of short-lived climate pollutants (SLCPs) such as methane are typically described using metrics that compare their climate impacts to carbon dioxide’s climate impact.
Andrew E Pomerantz, Robert L Kleinberg
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source