Results 1 to 10 of about 151,779 (318)
Gene Mutation Spectrum among Alpha-Thalassaemia Patients in Northeast Peninsular Malaysia
Diagnostics, 2023 (1) Background: Alpha (α)-thalassaemia is a genetic disorder that affects 5% of the world population. Deletional or nondeletional mutations of one or both HBA1 and HBA2 on chromosome 16 will result in reduced production of α-globin chains, a component of
Divashini Vijian +7 more
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Androglobin, a chimeric mammalian globin, is required for male fertility
eLife, 2022 Spermatogenesis is a highly specialized differentiation process driven by a dynamic gene expression program and ending with the production of mature spermatozoa.
Anna Keppner +15 more
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Iron Metabolism in Normal and Pathological Pregnancies and Fetal Consequences
Metabolites, 2022 Iron is required for energy production, DNA synthesis, and cell proliferation, mainly as a component of the prosthetic group in hemoproteins and as part of iron-sulfur clusters.
Charles Mégier +3 more
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İstanbul Tıp Fakültesi Dergisi, 2021 Objective: Alpha thalassemia is a common type of hemoglobinopathy that occurs as a result of deletions or point mutations in the alpha globin gene cluster.
Selma Demir +5 more
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Frontiers in Microbiology, 2023 Pectobacterium carotovorum is an important plant pathogen responsible for the destruction of crops through bacterial soft rot, which is modulated by oxygen (O2) concentration. A soluble globin coupled sensor protein, Pcc DgcO (also referred to as PccGCS)
Florian J. Fekete +4 more
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Distribution of cytoglobin in the mouse brain
Frontiers in Neuroanatomy, 2016 Cytoglobin (Cygb) is a vertebrate globin with so far poorly defined function. It is expressed in the fibroblast cell-lineage but has also been found in neurons.
Stefan eReuss +4 more
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TFII-I/Gtf2i and Erythro-Megakaryopoiesis
Frontiers in Physiology, 2020 TFII-I is a ubiquitously expressed transcription factor that positively or negatively regulates gene expression. TFII-I has been implicated in neuronal and immunologic diseases as well as in thymic epithelial cancer.
Aishwarya Gurumurthy +9 more
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Genetic and Epigenetic Therapies for β-Thalassaemia by Altering the Expression of α-Globin Gene
Frontiers in Genome Editing, 2021 β-Thalassaemia is caused by over 300 mutations in and around the β-globin gene that lead to impaired synthesis of β-globin. The expression of α-globin continues normally, resulting in an excess of α-globin chains within red blood cells and their ...
Sachith Mettananda, Sachith Mettananda
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Química Nova, 2013 Numerous functional biomolecules are associated with metals, i.e. the metallobiomolecules; more specifically, some are dependent on transition metals required for several crucial biological roles.
José A. L. da Silva
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ATF4 Regulates MYB to Increase γ-Globin in Response to Loss of β-Globin
Cell Reports, 2020 Summary: β-Hemoglobinopathies can trigger rapid production of red blood cells in a process known as stress erythropoiesis. Cellular stress prompts differentiating erythroid precursors to express high levels of fetal γ-globin.
Mandy Y. Boontanrart +9 more
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