Results 91 to 100 of about 74,517 (259)

Detecting phylogenetic relations out from sparse context trees [PDF]

arXiv, 2008
The goal of this paper is to study the similarity between sequences using a distance between the \emph{context} trees associated to the sequences. These trees are defined in the framework of \emph{Sparse Probabilistic Suffix Trees} (SPST), and can be estimated using the SPST algorithm.
arxiv  

Template Activity for Globin and Non-Globin Protein Synthesis in Reticulocytes

Journal of Biological Chemistry, 1972
Factors which control the rate of synthesis of two distinct classes of protein, globin and non-globin proteins, by free reticulocyte ribosomes have been investigated. Three different inhibitors of protein synthesis, puromycin, cycloheximide, and hydroxylamine, were more effective in inhibiting the synthesis of globin than of non-globin protein by free ...
Stephen I. Bulova, Edward R. Burka
openaire   +3 more sources

Preparation of Globin.

Experimental Biology and Medicine, 1929
Schulz1 in 1898 prepared globin, the protein moiety of hemoglobin, by extracting an acidified solution of oxyhemoglobin with a mixture of ether and alcohol. Most of the pigment went into the ether-alcohol layer, leaving the globin in the aqueous layer.
openaire   +2 more sources

Determination of Androgen Bioactivity by an In Vitro Assay During Pubertal Transition in Healthy Boys

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To describe the bioactivity of circulating androgens during pubertal transition as determined by an in vitro bioassay assessing androgen receptor (AR) activation, and to compare these findings with circulating concentrations of total testosterone (total T) measured by LC‐MS/MS.
Andrés Felipe Ø. Fritzbøger, Lise Aksglaede, Trine Holm Johannsen, Dirk Vanderschueren, Leen Antonio, Frank Claessens, Katrine Harpelunde Poulsen, Anne Jørgensen, Jørgen Holm Petersen, Anna‐Maria Andersson, Anders Juul   +10 more
wiley   +1 more source

Detection of Thalassaemia Carriers by Automated Feature Extraction of Dried Blood Drops [PDF]

arXiv, 2019
Thalassaemia, triggered by defects in the globin genes, is one of the most common monogenic diseases. The beta-thalassaemia carrier state is clinically asymptomatic, thus, making it onerous to diagnose. The current gold standard technique is implausible to be used for onsite carrier detection as the method necessitates expensive instruments, skilled ...
arxiv  

Making Molecular Diagnostics Faster

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Over the past 40 years, molecular diagnostic methods have evolved from multi‐step, time‐consuming protocols towards either rapid targeted tests or expansive, massively parallel testing. Aims Here we consider the speed limits of targeted molecular diagnostics, considering the three sequential required steps: nucleic acid preparation,
Carl T. Wittwer, Luming Zhou, Felix Ye, Adam Millington, Adrian de Cola, Noriko Kusukawa   +5 more
wiley   +1 more source

A Membrane-Bound Vertebrate Globin

PLoS ONE, 2011
The family of vertebrate globins includes hemoglobin, myoglobin, and other O(2)-binding proteins of yet unclear functions. Among these, globin X is restricted to fish and amphibians. Zebrafish (Danio rerio) globin X is expressed at low levels in neurons of the central nervous system and appears to be associated with the sensory system.
Blank, Miriam, Wollberg, Jessica, Gerlach, Frank, Reimann, Katja, Roesner, Anja, Hankeln, Thomas, Fago, Angela, Weber, Roy E., Burmester, Thorsten   +8 more
openaire   +6 more sources

Molecular Testing in Sickle Cell Disease: From Newborn Screening to Transfusion Care

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Sickle cell disease (SCD) is one of the most frequent monogenic diseases worldwide and a highly heterogeneous and complex disease. SCD care carries several challenges. This includes early and accurate diagnosis as well as optimal red blood cell transfusion matching in this population carrying a high risk of alloimmunization.
Thomas Pincez, Yves D. Pastore
wiley   +1 more source

Leukocyte telomere length and birth characteristics associated with obesity in infancy in a predominantly Latinx cohort

Pediatric Obesity, EarlyView.
Summary Background Previous studies suggest that in utero exposures may impact future weight gain trajectories in infancy. Leukocyte telomere length (LTL) collected at birth may be an additional variable to test in models for childhood obesity as adult studies suggest that LTL may be predictive of metabolic disease.
Abigail Duque, Jue Lin, Laura Jeliffe‐Pawlowski, Kim Coleman‐Phox, Larry Rand, Janet M. Wojcicki   +5 more
wiley   +1 more source

Proteomic analysis of plasma proteins during fentanyl withdrawal in ovariectomized female rats with and without estradiol

Journal of Neuroendocrinology, EarlyView.
Abstract Evidence from both clinical and preclinical studies indicates that females experience a faster progression to drug addiction and more severe addiction‐related health effects compared with males. Estradiol (E2) plays a critical role in these sex differences.
Patricia Sinclair, Navdeep S. Dhanjal, E. Blair Towers, Wendy J. Lynch, Nadine Kabbani   +4 more
wiley   +1 more source