Results 101 to 110 of about 173,792 (325)
Decrease of alpha-chains in beta-thalassemia
Thalassemia Reports, 2013 In the pathophysiology of beta-thalassemia, globin chain imbalance plays a central role in predicting red blood cell (RBC) life span and disease severity. Strategies to improve globin chain imbalance are therefore a legitimate target in the management of
M. Papadaki, George Vassilopoulos
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Control of Globin Gene Transcription [PDF]
Annual Review of Cell Biology, 1990 n ...
Evans, Todd +2 more
openaire +4 more sources
Drug Testing and Analysis, EarlyView.Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario Thevis +2 more
wiley +1 more source
ATF4 Regulates MYB to Increase γ-Globin in Response to Loss of β-Globin
Cell Reports, 2020 Summary: β-Hemoglobinopathies can trigger rapid production of red blood cells in a process known as stress erythropoiesis. Cellular stress prompts differentiating erythroid precursors to express high levels of fetal γ-globin.
Mandy Y. Boontanrart +9 more
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Human Genomics, 2020 The expression of the human β-like globin genes follows a well-orchestrated developmental pattern, undergoing two essential switches, the first one during the first weeks of gestation (ε to γ), and the second one during the perinatal period (γ to β). The
Petros Papadopoulos +15 more
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Visible Volume: a Robust Measure for Protein Structure Characterization [PDF]
, 1997 We propose a new characterization of protein structure based on the natural tetrahedral geometry of the β carbon and a new geometric measure of structural similarity, called visible volume.
Bashford +31 more
core +2 more sources
Developmental Dynamics, EarlyView.Abstract Homology in vertebrate body plans is traditionally ascribed to the high‐level conservation of regulatory components within the genetic programs governing them, particularly during the “phylotypic stage.” However, advancements in embryology and molecular phylogeny have unveiled the dynamic nature of gene repertoires responsible for early ...
Shigehiro Kuraku
wiley +1 more source
Globin-based redox signaling [PDF]
Worm, 2016 In recent years, moderate levels of reactive oxygen species (ROS) have become recognized as signaling cues that participate at all levels of cellular organization. Globins, with their redox-active heme iron and ubiquitous presence, seem ideally suited to participate in ROS metabolism.
De Henau, Sasha, Braeckman, Bart
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Developmental Dynamics, EarlyView.Abstract Disruption of extracellular pH and proton‐sensing can profoundly impact cellular and protein functions, leading to developmental defects. To visualize changes in extracellular pH in the developing embryo, we generated a zebrafish transgenic line that ubiquitously expresses the ratiometric pH‐sensitive fluorescent protein pHluorin2, tethered to
Leif R. Neitzel +5 more
wiley +1 more source
Nucleic Acids Research, 2014 TAL1 is a key hematopoietic transcription factor that binds to regulatory regions of a large cohort of erythroid genes as part of a complex with GATA-1, LMO2 and Ldb1. The complex mediates long-range interaction between the β-globin locus control region (
W. Yun +5 more
semanticscholar +1 more source