Results 101 to 110 of about 74,517 (259)

The effects of a globin blocker on the resolution of 3’mRNA sequencing data in porcine blood

BMC Genomics, 2019
Background Gene expression profiling in blood is a potential source of biomarkers to evaluate or predict phenotypic differences between pigs but is expensive and inefficient because of the high abundance of globin mRNA in porcine blood. These limitations
Kyu-Sang Lim, Qian Dong, Pamela Moll, Jana Vitkovska, Gregor Wiktorin, Stephanie Bannister, Dalia Daujotyte, Christopher K. Tuggle, Joan K. Lunney, Graham S. Plastow, Jack C. M. Dekkers   +10 more
doaj   +1 more source

Extracellular vesicles in ageing cold‐stored whole blood may not compensate for the decreasing haemostatic function in vitro

Transfusion Medicine, Volume 35, Issue 3, Page 275-286, June 2025.
Abstract Background Extracellular vesicles (EVs) have procoagulative properties. As EVs are known to accumulate in stored blood products, we compared the EV content and coagulation capacity of leukoreduced cold‐stored whole blood (CSWB) with current prehospital and in‐hospital component therapies to understand the role of EVs in the haemostatic ...
Petra Ilvonen, Sanna Susila, Ulla Impola, Reetta Pusa, Tuukka Helin, Lotta Joutsi‐Korhonen, Saara Laitinen, Jouni Lauronen, Minna Ilmakunnas   +8 more
wiley   +1 more source

Effect of AGM and fetal liver-derived stromal cell lines on globin expression in adult baboon (P. anubis) bone marrow-derived erythroid progenitors.

PLoS ONE, 2012
This study was performed to investigate the hypothesis that the erythroid micro-environment plays a role in regulation of globin gene expression during adult erythroid differentiation.
Donald Lavelle, Kestutis Vaitkus, Maria Armila Ruiz, Vinzon Ibanez, Tatiana Kouznetsova, Yogen Saunthararajah, Nadim Mahmud, Joseph DeSimone   +7 more
doaj   +1 more source

Metabolic stimulation improves bioenergetics and haematologic indices of circulating erythrocytes from sickle cell mice

The Journal of Physiology, EarlyView.
Abstract figure legend Metabolic stimulation improves bioenergetics, redox state, hydration and hematologic indices of circulating erythrocytes from sickle cell mice. Retained mitochondria in circulating RBCs from sickle mice are a source of RBC ATP as mitochondria function (ETC, electron transport chain) inhibitors [rotenone, a mitochondrial complex I
Luis E. F. Almeida, Meghann L. Smith, Sayuri Kamimura, Sebastian Vogel, Zenaide M. N. Quezado   +4 more
wiley   +1 more source

POGZ Is Required for Silencing Mouse Embryonic β-like Hemoglobin and Human Fetal Hemoglobin Expression

Cell Reports, 2018
Summary: Fetal globin genes are transcriptionally silenced during embryogenesis through hemoglobin switching. Strategies to derepress fetal globin expression in the adult could alleviate symptoms in sickle cell disease and β-thalassemia.
Bjorg Gudmundsdottir, Kristbjorn O. Gudmundsson, Kimberly D. Klarmann, Satyendra K. Singh, Lei Sun, Shweta Singh, Yang Du, Vincenzo Coppola, Luke Stockwin, Nhu Nguyen, Lino Tessarollo, Leifur Thorsteinsson, Olafur E. Sigurjonsson, Sveinn Gudmundsson, Thorunn Rafnar, John F. Tisdale, Jonathan R. Keller   +16 more
doaj  

Induction of endogenous γ-globin gene expression with decoy oligonucleotide targeting Oct-1 transcription factor consensus sequence

Journal of Hematology & Oncology, 2009
Human β-globin disorders are relatively common genetic diseases cause by mutations in the β-globin gene. Increasing the expression of the γ-globin gene has great benefits in reducing complications associated with these diseases.
Wang Gan, Hong Xin, Xu Xiaoxin S
doaj   +1 more source

Development of an HEK293 Suspension Cell Culture Medium, Transient Transfection Optimization Workflow, and Analytics for Batch rAAV Manufacturing

Biotechnology and Bioengineering, Volume 122, Issue 7, Page 1640-1655, July 2025.
ABSTRACT Recombinant adeno associated virus (rAAV) vectors have become popular delivery vehicles for in vivo gene therapies, but demand for rAAVs continues to outpace supply. Platform processes for rAAV production are being developed by many manufacturers, and transient chemical transfection of human embryonic kidney 293 (HEK293) cells is currently the
Erica A. Green, Qiang Fu, Nelson Ndahiro, Thomas M. Leibiger, Yongdan Wang, Yongsuk Lee, Kelvin H. Lee, Michael Betenbaugh, Seongkyu Yoon, David J. McNally   +9 more
wiley   +1 more source

Chimera of Globin/Nitric Oxide Synthase: Toward Improving Nitric Oxide Homeostasis and Nitrogen Recycling and Availability

Frontiers in Plant Science, 2020
Fiorella Del Castello, Andrés Nejamkin, Noelia Foresi, Lorenzo Lamattina, Natalia Correa-Aragunde   +4 more
doaj   +1 more source

DISTRIBUTION AND FATE OF INTRAVENOUSLY ADMINISTERED MODIFIED HUMAN GLOBIN AND ITS EFFECT ON BLOOD VOLUME. STUDIES UTILIZING I131 TAGGED GLOBIN 1 [PDF]

, 1953
Solomon A. Berson, Rosalyn S. Yalow, Joseph Post, Lawrence H. Wisham, Katharina Newerly, Manuel J. Villazon, Oscar Vazquez   +6 more
openalex   +1 more source

GATA Transcription Factors: A Cross‐Road for Erythropoiesis, Neurodevelopment, and Synucleinopathies

Developmental Neurobiology, Volume 85, Issue 3, July 2025.
ABSTRACT Alpha‐synuclein (α‐syn), a 140 amino acid protein, is abundantly expressed in the central nervous system (CNS) and in the erythrocytes, playing a pivotal role in the pathogenesis of Parkinson's disease (PD) and other synucleinopathies.
Francesco Bellomi, Claudia Caturano, Viola Velardi, Romina Mancinelli, Simone Carotti, Giorgio Vivacqua, Francesca Arciprete, Maria Zingariello   +7 more
wiley   +1 more source