Results 131 to 140 of about 151,779 (318)

CRISPR/Cas9-mediated γ-globin expression upregulation in HEK293T cells

Guangxi Yike Daxue xuebao
Objective To edit the γ-globin promoter of HEK293T cells using the CRISPR/Cas9 technology to upregulate γ-globin and explore the feasibility of using gene editing technology for the treatment of β-thalassemia.
HUANG Xianjuan, LAI Yongrong, LI Jing
doaj   +1 more source

Associations Between Climate‐Sensitive Nutrients, Clinical Malaria, and Anaemia Among Young Children in Rural Burkina Faso: An Analysis of Baseline Data From a Cluster‐Randomised Controlled Trial

Tropical Medicine &International Health, EarlyView.
ABSTRACT Objective Malaria and anaemia are significant public health challenges among young children in Burkina Faso, with complex interactions between climate variability, food security, and nutrient deficiencies. This study aimed to identify the malariometric profile and nutrient patterns among young children and to determine the associations of ...
Adi Lukas Kurniawan, Maria Virginia Borga, Fanta Zerbo, Carol Akinyi Abidha, Anais Gonnet, Raissa Sorgho, Boubacar Coulibaly, Ali Sié, Ina Danquah   +8 more
wiley   +1 more source

Miscoding by Escherichia coli tRNAs for Methionine, Cysteine and Valine in the Synthesis of Rabbit Globin [PDF]

, 1970
A. R. Hunter, Richard J. Jackson
openalex   +1 more source

A multi‐omics investigation of sarcopenia and frailty: Integrating genomic, epigenomic and telomere length data

Experimental Physiology, EarlyView.
Abstract Sarcopenia and frailty are complex geriatric syndromes influenced by a combination of genetic and environmental factors. Recent studies suggest that specific genetic variants, DNA methylation patterns and shortened telomeres are associated with age‐related diseases and might contribute to the development of both sarcopenia and frailty. In this
Valentina Ginevičienė, Erinija Pranckevičienė, Alina Urnikytė, Laura Jurkūnaitė, Kristijona Gutauskaitė, Rūta Dadelienė, Justina Kilaitė, Ieva Eglė Jamontaitė, Asta Mastavičiūtė, Ildus I. Ahmetov, Vidmantas Alekna   +10 more
wiley   +1 more source

Muscle oxygen saturation plateau: Definition and verification in different oxygen availability conditions in locomotor and non‐locomotor muscles

Experimental Physiology, EarlyView.
Abstract Novel wearable near‐infrared spectroscopy devices allow for a better understanding of muscle oxygenation kinetics during exercise. A muscle oxygen saturation (SmO2) plateau is often applied in the scientific literature, but clear criteria for its definition remain unestablished to date.
Tomasz Kowalski, Kinga Rębiś, Adrian Wilk, Dominika Granda, Andrzej Białecki, Tadej Debevec, Raphael Faiss   +6 more
wiley   +1 more source

Chimera of Globin/Nitric Oxide Synthase: Toward Improving Nitric Oxide Homeostasis and Nitrogen Recycling and Availability

Frontiers in Plant Science, 2020
Fiorella Del Castello, Andrés Nejamkin, Noelia Foresi, Lorenzo Lamattina, Natalia Correa-Aragunde   +4 more
doaj   +1 more source

Speciation in the baboon and its relation to gamma-chain heterogeneity and to the response to induction of HbF by 5-azacytidine [PDF]

, 1984
In the baboon (Papio species), the two nonallelic gamma-genes produce gamma-chains that differ at a minimum at residue 75, where isoleucine (I gamma-chain) or valine (V gamma) may be present.
DeSimone, Joseph, Espinueva, Zenaida, Hall, Lemuel, Huynh, Van, Schroeder, W. A., Shelton, J. Roger, Shelton, Joan B., Zwiers, David   +7 more
core  

Metabolic stimulation improves bioenergetics and haematologic indices of circulating erythrocytes from sickle cell mice

The Journal of Physiology, EarlyView.
Abstract figure legend Metabolic stimulation improves bioenergetics, redox state, hydration and hematologic indices of circulating erythrocytes from sickle cell mice. Retained mitochondria in circulating RBCs from sickle mice are a source of RBC ATP as mitochondria function (ETC, electron transport chain) inhibitors [rotenone, a mitochondrial complex I
Luis E. F. Almeida, Meghann L. Smith, Sayuri Kamimura, Sebastian Vogel, Zenaide M. N. Quezado   +4 more
wiley   +1 more source

Detection of Rare Thalassemia Variants Using Accurate Circular Consensus Long-Read Sequencing. [PDF]

Hum Mutat
Objective The aim of this study is to evaluate the efficacy of accurate circular consensus long‐read sequencing in the detection of rare thalassemia. Methods Conventional molecular analysis on globin genes has limitations because of the broad spectrum of genetic variants, complex genetics, and genotype–phenotype correlation. Accurate circular consensus
Zhou X, Chen Y, Chen S, Lian J, Liu Y, Yang T, Wu S, Liu J, Huang X, Yang X.   +9 more
europepmc   +2 more sources

Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling

Brain and Behavior, Volume 16, Issue 2, February 2026.
Histone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Degisew Yinur Mengistu, Biniam Moges Eskeziyaw   +1 more
wiley   +1 more source