Results 11 to 20 of about 151,779 (318)

Analysis of β-globin Chromatin Micro-Environment Using a Novel 3C Variant, 4Cv [PDF]

, 2010
Copyright: © 2010 Pink et al.Higher order chromatin folding is critical to a number of developmental processes, including the regulation of gene expression.
Ryan Pink, Christopher H. Eskiw, Daniel P. Caley, David R. F. Carter   +3 more
openalex   +6 more sources

A Novel High-Content Immunofluorescence Assay as a Tool to Identify at the Single Cell Level γ-Globin Inducing Compounds. [PDF]

PLoS ONE, 2015
The identification of drugs capable of reactivating γ-globin to ameliorate β-thalassemia and Sickle Cell anemia is still a challenge, as available γ-globin inducers still have limited clinical indications.
Marta Durlak, Cristina Fugazza, Sudharshan Elangovan, Maria Giuseppina Marini, Maria Franca Marongiu, Paolo Moi, Ivan Fraietta, Paolo Cappella, Paolo Cappella, Gloria Barbarani, Isaura Font-Monclus, Mario Mauri, Sergio Ottolenghi, Fabio Gasparri, Antonella Ronchi   +14 more
doaj   +6 more sources

CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the {\beta}-globin locus [PDF]

, 2012
The principles underlying the architectural landscape of chromatin beyond the nucleosome level in living cells remains largely unknown despite its potential to play a role in mammalian gene regulation. We investigated the 3-dimensional folding of a 1 Mbp
Ann Dean, Bau, Bau, Bender, Bender, Botta, Chunhui Hou, Cook, Cui, de Gennes, Dekker, Dorier, Dostie, Drissen, Duan, Farrell, François Képès, Fraser, Hadjur, Handoko, Hou, Hou, Ivan Junier, Junier, Kalhor, Kiefer, Kim, Krivega, Kurukuti, Langowski, Lee, Lieberman-Aiden, Marenduzzo, Mateos-Langerak, Mukhopadhyay, Murrell, Ong, Palstra, Phillips, Ragoczy, Reuillon, Rosa, Rousseau, Ryan K. Dale, Schoenfelder, Sexton, Sexton, Simonis, Song, Song, Splinter, Stamatoyannopoulos, Strick, Tolhuis, Vakoc, Wallace, Yaffe   +56 more
core   +13 more sources

The human ankyrin 1 promoter insulator sustains gene expression in a β-globin lentiviral vector in hematopoietic stem cells. [PDF]

, 2015
Lentiviral vectors designed for the treatment of the hemoglobinopathies require the inclusion of regulatory and strong enhancer elements to achieve sufficient expression of the β-globin transgene.
Baldwin, Kismet M, Campo-Fernandez, Beatriz, Cooper, Aaron R, Hoban, Megan D, Hollis, Roger P, Kaufman, Michael L, Kohn, Donald B, Lumaquin, Dianne, Romero, Zulema, Senadheera, Shantha, Urbinati, Fabrizia, Wang, Xiaoyan, Wherley, Jennifer   +12 more
core   +8 more sources

RNA Sequencing (RNA-Seq) Reveals Extremely Low Levels of Reticulocyte-Derived Globin Gene Transcripts in Peripheral Blood From Horses (Equus caballus) and Cattle (Bos taurus)

Frontiers in Genetics, 2018
RNA-seq has emerged as an important technology for measuring gene expression in peripheral blood samples collected from humans and other vertebrate species.
Carolina N. Correia, Kirsten E. McLoughlin, Nicolas C. Nalpas, David A. Magee, John A. Browne, Kevin Rue-Albrecht, Stephen V. Gordon, Stephen V. Gordon, David E. MacHugh, David E. MacHugh   +9 more
doaj   +1 more source

3,3′,5-Triiodothyroacetic acid (TRIAC) induces embryonic ζ-globin expression via thyroid hormone receptor α

Journal of Hematology & Oncology, 2021
The human ζ-globin gene (HBZ) is transcribed in primitive erythroid cells only during the embryonic stages of development. Reactivation of this embryonic globin synthesis would likely alleviate symptoms both in α-thalassemia and sickle-cell disease ...
Huiqiao Chen, Zixuan Wang, Shanhe Yu, Xiao Han, Yun Deng, Fuhui Wang, Yi Chen, Xiaohui Liu, Jun Zhou, Jun Zhu, Hao Yuan   +10 more
doaj   +1 more source

Prevalence and genetic analysis of triplicated α-globin gene in Ganzhou region using high-throughput sequencing

Frontiers in Genetics, 2023
α-globin gene triplication carriers were not anemic in general, while some studies found that α-globin gene triplication coinherited with heterozygous β-thalassemia may cause adverse clinical symptoms, which yet lacks sufficient evidence in large ...
Xinxing Xie, Jinhui Gan, Zezhang Liu, Zezhang Liu, Yulian Zhou, Kun Yuan, Kun Yuan, Zhigang Chen, Zhigang Chen, Shiping Chen, Rui Zhou, Rui Zhou, Lipei Liu, Lipei Liu, Xiaoyan Huang, Yan Zhang, Yan Zhang, Qian Liu, Qian Liu, Wenqian Zhang, Wenqian Zhang, Jungao Huang, Junkun Chen   +22 more
doaj   +1 more source

Nerve Globins in Invertebrates

IUBMB Life, 2004
AbstractThe expression of nerve hemoglobins in invertebrates is a well‐established fact, but this occurrence is uncommon. In the species where nerve globins occur, they probably function as an oxygen store for sustaining activity of the nerves during anoxic conditions.
GEUENS E., DEWILDE S., HOOGEWIJS D., PESCE, ALESSANDRA, NIENHAUS K., NIENHAUS G. U., OLSON J., VANFLETEREN J., BOLOGNESI, MARTINO, MOENS L.   +9 more
openaire   +5 more sources

Globins in Caenorhabditis elegans

IUBMB Life, 2011
AbstractExtensive in silico search of the genome of Caenorhabditis elegans revealed the presence of 33 genes coding for globins that are all transcribed. These globins are very diverse in gene and protein structure and are localized in a variety of cells, mostly neurons. The large number of C.
Tilleman, L, Germani, F, De Henau, S, Geuens, E, Hoogewijs, D, Braeckman, B P, Vanfleteren, J R, Moens, L, Dewilde, S   +8 more
openaire   +5 more sources

VEZF1 elements mediate protection from DNA methylation [PDF]

, 2010
There is growing consensus that genome organization and long-range gene regulation involves partitioning of the genome into domains of distinct epigenetic chromatin states.
AC Bell, Adam G. West, AG West, AG West, AG West, Alan Hair, CD Lewis, CL Li, D Macleod, F Antequera, F Recillas-Targa, Gary Felsenfeld, H Gowher, Humaira Gowher, IG Lin, J Aitsebaomo, J Stalder, JA Wallace, Jacqueline Dickson, JH Chung, JH Chung, JP Issa, KS Wendt, L Valenzuela, Lisa Stubbs, M Brandeis, M Gaszner, M Marin, M Oki, MC Barton, Miklos Gaszner, MJ Pikaart, MM Suzuki, MN Prioleau, MN Prioleau, MS Turker, N Koyano-Nakagawa, PA Jones, PB Talbert, PD Jackson, PE Szabo, R Buckle, R Jaenisch, R Kellum, R Straussman, Ruslan Strogantsev, S Fan, S Huang, S Huang, S Yao, SP Clark, T Hashimshony, V Mutskov, VJ Mutskov, VK Rakyan   +54 more
core   +5 more sources