Results 21 to 30 of about 146,684 (275)

VEZF1 elements mediate protection from DNA methylation [PDF]

open access: yes, 2010
There is growing consensus that genome organization and long-range gene regulation involves partitioning of the genome into domains of distinct epigenetic chromatin states.
AC Bell   +54 more
core   +9 more sources

A simple, highly efficient method for heterologous expression in mammalian primary neurons using cationic lipid-mediated mRNA transfection

open access: yesFrontiers in Neuroscience, 2010
Expression of heterologous proteins in adult mammalian neurons is a valuable technique for the study of neuronal function. The postmitotic nature of mature neurons prevents effective DNA transfection using simple, cationic lipid-based methods.
Damian J Williams   +2 more
doaj   +1 more source

TFII-I/Gtf2i and Erythro-Megakaryopoiesis

open access: yesFrontiers in Physiology, 2020
TFII-I is a ubiquitously expressed transcription factor that positively or negatively regulates gene expression. TFII-I has been implicated in neuronal and immunologic diseases as well as in thymic epithelial cancer.
Aishwarya Gurumurthy   +9 more
doaj   +1 more source

Analysis of β-globin chromatin micro-environment using a novel 3C variant, 4Cv [PDF]

open access: yes, 2010
Copyright: © 2010 Pink et al.Higher order chromatin folding is critical to a number of developmental processes, including the regulation of gene expression.
Christopher H Eskiw   +4 more
core   +3 more sources

Genetic and Epigenetic Therapies for β-Thalassaemia by Altering the Expression of α-Globin Gene

open access: yesFrontiers in Genome Editing, 2021
β-Thalassaemia is caused by over 300 mutations in and around the β-globin gene that lead to impaired synthesis of β-globin. The expression of α-globin continues normally, resulting in an excess of α-globin chains within red blood cells and their ...
Sachith Mettananda, Sachith Mettananda
doaj   +1 more source

A etimologia de biomoléculas com metais de transição como auxiliar na aprendizagem de Química Biológica

open access: yesQuímica Nova, 2013
Numerous functional biomolecules are associated with metals, i.e. the metallobiomolecules; more specifically, some are dependent on transition metals required for several crucial biological roles.
José A. L. da Silva
doaj   +1 more source

RNA Sequencing (RNA-Seq) Reveals Extremely Low Levels of Reticulocyte-Derived Globin Gene Transcripts in Peripheral Blood From Horses (Equus caballus) and Cattle (Bos taurus)

open access: yesFrontiers in Genetics, 2018
RNA-seq has emerged as an important technology for measuring gene expression in peripheral blood samples collected from humans and other vertebrate species.
Carolina N. Correia   +9 more
doaj   +1 more source

Prevalence and genetic analysis of triplicated α-globin gene in Ganzhou region using high-throughput sequencing

open access: yesFrontiers in Genetics, 2023
α-globin gene triplication carriers were not anemic in general, while some studies found that α-globin gene triplication coinherited with heterozygous β-thalassemia may cause adverse clinical symptoms, which yet lacks sufficient evidence in large ...
Xinxing Xie   +22 more
doaj   +1 more source

Control of globin gene expression by Kruppel-like factors [PDF]

open access: yes, 2014
Kruppel-like factors (KLFs) are a family of seventeen proteins designated KLF1 to KLF17. KLFs are transcriptional factors that bind GC-rich sequences such as CACCC elements. The DNA binds to KLFs via three carboxyl-terminal Cys-2/His-2 zinc fingers. KLFs
Borg, Joseph, Grech, Laura
core   +1 more source

Nerve Globins in Invertebrates

open access: yesIUBMB Life, 2004
AbstractThe expression of nerve hemoglobins in invertebrates is a well‐established fact, but this occurrence is uncommon. In the species where nerve globins occur, they probably function as an oxygen store for sustaining activity of the nerves during anoxic conditions.
GEUENS E.   +9 more
openaire   +6 more sources

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