Results 41 to 50 of about 146,684 (275)

Globin and Globin Gene Structure of the Nerve Myoglobin of Aphrodite aculeata [PDF]

Journal of Biological Chemistry, 1996
The globin of the nerve cord of the polychaete annelid Aphrodite aculeata was isolated and purified to homogeneity. The native molecule has a pI of 6.3 and acts as a dimer of two identical Mr 15, 644.5 polypeptide chains as determined by electrospray mass spectrometry.
Dewilde, Sylvia, Blaxter, Mark, van Hauwaert, Marie-Louise, Vanfleteren, Jacques, Esmans, Edgard, Marden, Mike, Griffon, Nathalie, Moens, Luc   +7 more
openaire   +3 more sources

Reactivation of a developmentally silenced embryonic globin gene

Nature Communications, 2021
Globin loci harbor genes that are expressed embryonically and silenced postnatally. Here the authors show that zeta-globin silencing depends upon selective hypoacetylation of its TAD subdomain, which blocks its interaction with the alpha-globin super ...
Andrew J. King, Duantida Songdej, Damien J. Downes, Robert A. Beagrie, Siyu Liu, Megan Buckley, Peng Hua, Maria C. Suciu, A. Marieke Oudelaar, Lars L. P. Hanssen, Danuta Jeziorska, Nigel Roberts, Stephanie J. Carpenter, Helena Francis, Jelena Telenius, Aude-Anais Olijnik, Jacqueline A. Sharpe, Jacqueline Sloane-Stanley, Jennifer Eglinton, Mira T. Kassouf, Stuart H. Orkin, Len A. Pennacchio, James O. J. Davies, Jim R. Hughes, Douglas R. Higgs, Christian Babbs   +25 more
doaj   +1 more source

Formation of the Native Topology of a Protein is due to the “Conserved but Non-Functional” Residues: A Case of Apomyoglobin Folding

Frontiers in Bioscience-Landmark
This paper is dedicated to the memory of Oleg B. Ptitsyn (1929-1999) and presents an answer to his question: “What is the role of conserved non-functional residues in protein folding?”. This answer follows from the experimental works of three labs.
Valentina E. Bychkova, Dmitry A. Dolgikh, Vitalii A. Balobanov, Alexei V. Finkelstein   +3 more
doaj   +1 more source

Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts. [PDF]

PLoS ONE, 2016
In human adult erythroid cells, lower than normal levels of Krüppel-like transcription factor 1 (KLF1) are generally associated with decreased adult β- and increased fetal γ-globin gene expression. KLF1 also regulates BCL11A, a known repressor of adult γ-
Divya S Vinjamur, Yousef N Alhashem, Safa F Mohamad, Parth Amin, David C Williams, Joyce A Lloyd   +5 more
doaj   +1 more source

Human globin ψB₂is not a globin-related sequence [PDF]

Nucleic Acids Research, 1982
We have determined the complete nucleotide sequence of 3.4 kilobase pairs of DNA covering the region of the human beta globin gene cluster where a human globin-related sequence psi beta 2 was thought to lie (Fritsch, Lawn, and Maniatis (1980) Cell 19, 959-972).
Shi hsiang Shen, Oliver Smithies
openaire   +3 more sources

Imbalanced globin chain synthesis determines erythroid cell pathology in thalassemic mice

Haematologica, 2009
Background β-thalassemia occurs from the imbalanced globin chain synthesis due to the absence or inadequate β-globin chain production. The excessive unbound α-globin chains precipitate in erythroid precursors and mature red blood cells leading to ...
Kanitta Srinoun, Saovaros Svasti, Worrakavee Chumworathayee, Jim Vadolas, Phantip Vattanaviboon, Suthat Fucharoen, Pranee Winichagoon   +6 more
doaj   +1 more source

Physiological and Aberrant γ-Globin Transcription During Development

Frontiers in Cell and Developmental Biology, 2021
The expression of the fetal Gγ- and Aγ-globin genes in normal development is confined to the fetal period, where two γ-globin chains assemble with two α-globin chains to form α2γ2 tetramers (HbF). HbF sustains oxygen delivery to tissues until birth, when
Gloria Barbarani, Agata Labedz, Sarah Stucchi, Alessia Abbiati, Antonella E. Ronchi   +4 more
doaj   +1 more source

A Phylogenetic Analysis of the Globins in Fungi [PDF]

PLoS ONE, 2012
All globins belong to one of three families: the F (flavohemoglobin) and S (sensor) families that exhibit the canonical 3/3 α-helical fold, and the T (truncated 3/3 fold) globins characterized by a shortened 2/2 α-helical fold. All eukaryote 3/3 hemoglobins are related to the bacterial single domain F globins.
Hoogewijs, D, Dewilde, S, Vierstraete, A, Moens, L, Vinogradov, S N   +4 more
openaire   +5 more sources

The role of WDR5 in silencing human fetal globin gene expression

Haematologica, 2012
Background Histone H3 lysine 4 (K4) methylation has been linked with transcriptional activity in mammalian cells. The WD40-repeat protein, WDR5, is an essential component of the MLL complex that induces histone H3 K4 methylation, but the role of WDR5 in ...
Zhen Xu, Yinghong He, Junyi Ju, Gerhard Rank, Loretta Cerruti, Chi Ma, Richard J. Simpson, Robert L. Moritz, Stephen M. Jane, Quan Zhao   +9 more
doaj   +1 more source

Creating New β-Globin-Expressing Lentiviral Vectors by High-Resolution Mapping of Locus Control Region Enhancer Sequences. [PDF]

, 2020
Hematopoietic stem cell gene therapy is a promising approach for treating disorders of the hematopoietic system. Identifying combinations of cis-regulatory elements that do not impede packaging or transduction efficiency when included in lentiviral ...
Aleshe, Bamidele, Ayoub, Paul George, Brown, Devin, Hollis, Roger P, Kohn, Donald B, Kurita, Ryo, Lathrop, Lindsay, Ma, Feiyang, Morgan, Richard A, Nakamura, Yukio, Pellegrini, Matteo, Senadheera, Shantha, Tam, Curtis, Unti, Mildred J, Wong, Ryan L   +14 more
core   +1 more source