Results 51 to 60 of about 173,792 (325)
Blood, 2019 β-hemoglobinopathies, such as sickle cell disease and β-thalassemia, result from mutations in the adult β-globin gene. Reactivating the developmentally silenced fetal γ-globin gene elevates fetal hemoglobin levels and ameliorates symptoms of β ...
Gabriella E Martyn +5 more
semanticscholar +1 more source
Cotranslational Folding of Globin [PDF]
Journal of Biological Chemistry, 1997 Globin synthesis in a wheat germ cell-free translation system was performed in the presence of [3H]hemin and [35S]methionine to determine the minimal length of the nascent ribosome-bound globin chain capable of heme binding. Nascent polypeptides of predetermined size were synthesized on ribosomes by translation of truncated mRNA molecules.
Anton A. Komar +3 more
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The autophagy-activating kinase ULK1 mediates clearance of free α-globin in β-thalassemia
Science Translational Medicine, 2019 Rapamycin alleviates β-thalassemia by stimulating ULK1-dependent clearance of toxic free α-globin. Unclogging red blood cells In β-thalassemia, a genetic disorder caused by mutations in the β-globin subunit of adult hemoglobin, the pathological ...
Christophe Lechauve +17 more
semanticscholar +1 more source
Globins in Caenorhabditis elegans
IUBMB Life, 2011 AbstractExtensive in silico search of the genome of Caenorhabditis elegans revealed the presence of 33 genes coding for globins that are all transcribed. These globins are very diverse in gene and protein structure and are localized in a variety of cells, mostly neurons. The large number of C.
Tilleman, L +8 more
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Differences in cattle globins [PDF]
Biochemical Journal, 1965 1. Comparisons have been made between electrophoretic mobilities of the cattle haemoglobins, HbA, HbB, HbC, HbD and HbF, at pH8.9. The fastest was HbB, then came in decreasing order HbF, HbC, HbA and HbD. 2. Globins were prepared from the main fractions of the five haemoglobins by CM-cellulose chromatography and investigated by starch-gel ...
M Braend, G Efremov
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Italian Journal of Animal Science, 2019 The feed utilisation of young chicks is characterised by a suboptimal fat digestibility, which can be improved by means of dietary emulsifiers. The objective of this study was to evaluate the effect of dietary Globin on the energy efficiency and ...
Sihem Dabbou +11 more
doaj +1 more source
Chromatin insulator elements: establishing barriers to set heterochromatin boundaries [PDF]
, 2012 Epigenomic profiling has revealed that substantial portions of genomes in higher eukaryotes are organized into extensive domains of transcriptionally repressive chromatin.
Adam G West +9 more
core +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance RNA containing only pyrimidines, transcribed from genomic DNA, can form DNA∙RNA triple helices with other sites in the genome. We characterize an intronic sequence in the human β-globin gene that forms a triplex with an upstream regulatory ...
Zhuo Zhou, K. Giles, G. Felsenfeld
semanticscholar +1 more source
Primitive and definitive erythropoiesis in mammals
Frontiers in Physiology, 2014 Red blood cells (RBCs), which constitute the most abundant cell type in the body, come in two distinct flavors- primitive and definitive. Definitive RBCs in mammals circulate as smaller, anucleate cells during fetal and postnatal life, while primitive ...
James ePalis
doaj +1 more source
Globin genes on the move [PDF]
Journal of Biology, 2008 Recent data published in BMC Biology from the globin gene clusters in platypus, together with data from other species, show that beta-globin genes transposed from one chromosomal location to another. This resolves some controversies about vertebrate globin gene evolution but ignites new ones.
openaire +3 more sources