Results 71 to 80 of about 173,792 (325)
Gene Therapy of the β-Hemoglobinopathies by Lentiviral Transfer of the βA(T87Q)-Globin Gene
Human Gene Therapy, 2016 β-globin gene disorders are the most prevalent inherited diseases worldwide and result from abnormal β-globin synthesis or structure. Novel therapeutic approaches are being developed in an effort to move beyond palliative management.
O. Nègre +10 more
semanticscholar +1 more source
Human globin ψB2is not a globin-related sequence [PDF]
Nucleic Acids Research, 1982 We have determined the complete nucleotide sequence of 3.4 kilobase pairs of DNA covering the region of the human beta globin gene cluster where a human globin-related sequence psi beta 2 was thought to lie (Fritsch, Lawn, and Maniatis (1980) Cell 19, 959-972).
Shi hsiang Shen, Oliver Smithies
openaire +3 more sources
Imbalanced globin chain synthesis determines erythroid cell pathology in thalassemic mice
Haematologica, 2009 Background β-thalassemia occurs from the imbalanced globin chain synthesis due to the absence or inadequate β-globin chain production. The excessive unbound α-globin chains precipitate in erythroid precursors and mature red blood cells leading to ...
Kanitta Srinoun +6 more
doaj +1 more source
Physiological and Aberrant γ-Globin Transcription During Development
Frontiers in Cell and Developmental Biology, 2021 The expression of the fetal Gγ- and Aγ-globin genes in normal development is confined to the fetal period, where two γ-globin chains assemble with two α-globin chains to form α2γ2 tetramers (HbF). HbF sustains oxygen delivery to tissues until birth, when
Gloria Barbarani +4 more
doaj +1 more source
Cryptic transcripts from a ubiquitous plasmid origin of replication confound tests for cis-regulatory function. [PDF]
, 2012 A vast amount of research on the regulation of gene expression has relied on plasmid reporter assays. In this study, we show that plasmids widely used for this purpose constitutively produce substantial amounts of RNA from a TATA-containing cryptic ...
Hiraoka, Kei +3 more
core +2 more sources
Nature Communications, 2017 β-Thalassemia is one of the most common inherited anemias, with no effective cure for most patients. The pathophysiology reflects an imbalance between α- and β-globin chains with an excess of free α-globin chains causing ineffective erythropoiesis and ...
S. Mettananda +21 more
semanticscholar +1 more source
A Phylogenetic Analysis of the Globins in Fungi [PDF]
PLoS ONE, 2012 All globins belong to one of three families: the F (flavohemoglobin) and S (sensor) families that exhibit the canonical 3/3 α-helical fold, and the T (truncated 3/3 fold) globins characterized by a shortened 2/2 α-helical fold. All eukaryote 3/3 hemoglobins are related to the bacterial single domain F globins.
Hoogewijs, D +4 more
openaire +5 more sources
The role of WDR5 in silencing human fetal globin gene expression
Haematologica, 2012 Background Histone H3 lysine 4 (K4) methylation has been linked with transcriptional activity in mammalian cells. The WD40-repeat protein, WDR5, is an essential component of the MLL complex that induces histone H3 K4 methylation, but the role of WDR5 in ...
Zhen Xu +9 more
doaj +1 more source
Proceedings of the National Academy of Sciences, 2006 A crucial requirement of metabolically active aerobic cells is a steady supply of oxygen. The red pigment of vertebrate skeletal muscle, oxygen-binding myoglobin (Mb), serves this function by facilitating the delivery of O 2 from the plasma membrane to the energy-producing mitochondria (1). The delivery of O2 from lungs or gills to muscles is also very
Thomas A. Gorr, Austen Riggs
openaire +3 more sources
Introduction and Expression of a Rabbit β-globin Gene in Mouse Fibroblasts [PDF]
, 1979 The cloned chromosomal rabbit ß-globin gene has been introduced into mouse fibroblasts by DNA-mediated gene transfer (transformation). In this report, we examine the expression of the rabbit gene in six independent transformants that contain from 1 to 20
Axel, R. +5 more
core