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Evaluation and treatment of familial globozoospermia in five brothers
Fertility and Sterility, 2004To document the pathology of five siblings with complete globozoospermia and to report the effectiveness of repeated intracytoplasmic sperm injection (ICSI) treatment as therapy.Case report.A tertiary center for assisted reproduction.Five siblings with globozoospermia.Twenty cycles of repeated ICSI treatment.
Christopher Barratt
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Globozoospermia syndrome: An update
Andrologia, 2019Among the factors involved in male infertility, there is a rare morphology disorder called "globozoospermia" that is classified into total globozoospermia and partial globozoospermia (type I and type II, respectively). This syndrome is primarily characterised by the presence of round-headed spermatozoa with cytoskeleton defects around the nucleus and ...
Farzaneh Fesahat +2 more
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Globozoospermia Syndrome : Two Case Reports
Lebanese Medical Journal, 2014Globozoospermia is a rare but severe cause of male infertility. The presence of 100% round-headed spermatozoa and lack of acrosome are the diagnostic criteria of total globozoospermia. The pathogenesis of globozoospermia most probably originates in spermiogenesis, specifically in acrosome formation and sperm head elongation.
Sanam, Moradan, Behpour, Yousefi
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Chromatin Structure in Globozoospermia: A Case Report
Journal of Andrology, 2001ABSTRACT: Sperm nuclear abnormalities in patients with globozoospermia have not been well characterized and may lead to the high rates of fertilization failure and embryo loss reported in patients with this form of teratozoospermia. This study used transmission electron microscopy (TEM), the sperm chromatin structure assay (SCSA), and single cell gel ...
K L, Larson +7 more
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Proteomic Research of Molecular Defects in Globozoospermia
PROTEOMICS – Clinical Applications, 2019AbstractGlobozoospermia is a form of teratozoospermia characterized by round‐headed spermatozoa and lack of acrosome. These spermatozoa cannot penetrate the zona pellucida of the oocyte, resulting in unsuccessful fertilization and infertility. When intracytoplasmic sperm injection is performed, the fertilization rate tends to be low.
Simone Ferrero, Fabio Barra
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Sperm chromosome aneuploidy analysis in a man with globozoospermia
Fertility and Sterility, 2003To determine the frequencies of chromosome aneuploidy and diploidy in sperm from a male with globozoospermia.Assessment of sperm chromosome aneuploidy and diploidy frequencies by multicolor fluorescence in situ hybridization (FISH) analysis.University research laboratory.An infertile patient with round-headed sperm (globozoospermia).Sperm samples were ...
Renée H, Martin +2 more
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Molecular cytogenetic and genetic aspects of globozoospermia: a review
Andrologia, 2012Infertility is estimated to affect up to 15% of couples of reproductive age. Among the male factors, globozoospermia (also called round-headed sperm syndrome) is a rare type of teratozoospermia accounting for
A, Perrin +6 more
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Association between total globozoospermia and sperm chromatin defects
Andrologia, 2017Globozoospermia is a severe sperm morphological anomaly leading to primary infertility and low fertilisation following intracytoplasmic sperm injection (ICSI). This phenotype is observed in less than 0.1% of infertile men and is determined by small, round-headed spermatozoa with absence of an acrosomal cap, acrosome protease and also cytoskeletal ...
N. Eskandari +3 more
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[Globozoospermia syndrome: an update].
Zhonghua nan ke xue = National journal of andrology, 2011Globozoospermia syndrome is a rare teratozoospermia, with an incidence of less than 0.1%. It is characterized by round sperm head, absence of acrosome, and messy sperm body and tail, but without other special clinical features. The absence of acrosome could reduce the activation ability of oocytes, and consequently decrease their fertilization ability.
Yan-wei, Sha, Yue-qiang, Song, Bin, Han
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[Molecular genetics of globozoospermia: an update].
Zhonghua nan ke xue = National journal of andrology, 2012Globozoospermia, as a severe teratozoospermia caused by gene mutations, is a rare congenital disease with main clinical manifestations of the round head of sperm and abnormality or absence of acrosome, and its precise mechanism is not yet clear. Studies show that the pathogenic genes associated with globozoospermia include SPATA16, PICK1, GOPC, Hrb ...
Lei, Wan, Li-mei, An, Xin-yi, Xia
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