Results 101 to 110 of about 2,192 (198)

SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia [PDF]

SPACA1 is a membrane protein that localizes in the equatorial segment of spermatozoa in mammals and is reported to function in sperm-egg fusion. We produced a Spaca1 gene-disrupted mouse line and found that the male mice were infertile. The cause of this
Okabe, Masaru, Ikawa, Masahito, Satouh, Yuhkoh, Fujihara, Yoshitaka, Inoue, Naokazu, Isotani, Ayako   +5 more
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Globozoospermia: the last Castle in male Infertility

, 2005
The morphological and functional integrity of the acrosome in human spermatozoa is a prerequisite for attachment and binding to the ovum investments in order to allow gamete fusion. Globozoospermia is a rare condition of unknown mode of inheritance which
GÜNALP, GALİP SERDAR, Taskiran, Cagatay, BAŞARAN, AHMET   +2 more
core  

Analysis of 232 total fertilization failure cycles during intracytoplasmic sperm injection [PDF]

Iranian Journal of Reproductive Medicine, 2011
Background: The intracytoplasmic sperm injection procedure ending with total fertilization failure is very distressfull event for both the clinician and the patient.Objective: The aim of this study was to identify independent factors which could be used ...
Esma Sarikaya, Ozlem Gun Eryilmaz, Ruya Deveer, Muammer Dogan, Leyla Mollamahmutoglu   +4 more
doaj  

The identification of AMZ2 as a candidate causative gene in a severe teratozoospermia patient characterized by vacuolated spermatozoa

Asian Journal of Andrology
Teratozoospermia with cephalic defects is one of the most severe types of sperm defects known to date. While several monogenic factors are linked to cephalic abnormalities, such as globozoospermia and macrozoospermia, the genetic cause of vacuolated ...
Liu Liu, Jing Yang, Wen-Jing Zhang, Yi-Ling Zhou, Gui-Jun Zhao, Ya Huang, Shu-Yan Tang   +6 more
doaj   +1 more source

Successful childbirth after intracytoplasmic morphologically selected sperm injection without assisted oocyte activation in a patient with globozoospermia

, 2011
International audienceWe here report a successful pregnancy and healthy childbirth obtained in a case of total globozoospermia after intracytoplasmic morphologically selected sperm injection (IMSI) without assisted oocyte activation (AOA).
C. Palacios, C. Sifer, Sermondade, Nathalie, Bechoua, S., R. Levy, Palacios, C., Sifer, C., F. Eustache, Eustache, F., Poncelet, C., Hafhouf, E., Levy, Rachel, S. Bechoua, Benzacken, B., Dupont, C., N. Sermondade, C. Poncelet, E. Hafhouf, C. Dupont, B. Benzacken   +19 more
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A successful healthy childbirth and an ongoing evolutive pregnancy in a case of partial globozoospermia by hyaluronic acid sperm selection

, 2018
We here report a successful healthy childbirth and an ongoing evolutive pregnancy in a case of partial globozoospermia after selection of mature spermatozoa bound to hyaluronic acid (HA). The couple underwent two in vitro fertilisation (IVF) cycles.
Remorgida, Valentino, Massarotti, Claudia, De Leo, Caterina, Canepa, Pierandrea, Scaruffi, Paola, Casciano, Ida, Anserini, Paola   +6 more
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Globozoospermia - Do Y-chromosome microdeletions play a role in this rare spermatogenic disorder?

, 2006
OBJECTIVE: To explore the possible relationship between Y-chromosome microdeletions and a rare spermatogenic disorder ...
Gunalp, Serdar, Baltaci, Volkan, Taskiran, Cagatay   +2 more
core  

Non-lysosomal accumulation of glucosylceramide alters cytoskeletal dynamics causing globozoospermia [PDF]

, 2015
Glycosphingolipids are important constituents of cellular membranes. Glucosylceramide (GlcCer) is the simplest glycosphingolipid and serves as a building block for the synthesis of higher-order glycosphingolipids.
Raju, D., Raju, Diana Nancy
core  

Mfsd14a (Hiat1) gene disruption causes globozoospermia and infertility in male mice.

, 2016
The Mfsd14a gene, previously called Hiat1, encodes a transmembrane protein of unknown function with homology to the solute carrier protein family. To study the function of the MFSD14A protein, mutant mice (Mus musculus, strain 129S6Sv/Ev) were generated ...

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Decreased Expression of KIFC1 in Human Testes with Globozoospermic Defects

, 2016
Globozoospermia is a rare (prevalence of <0.1%) but severe male infertility condition. In our previous study, we found that robust KIFC1 immunostaining was detected in the human elongating/elongated spermatids during human acrosomogenesis.
Xiaobin Zhu, Zheng Li, Peng Li, Huixing Chen, Peng Xu, Erlei Zhi, Zijue Zhu, Zuping He   +7 more
core   +1 more source