Results 81 to 90 of about 2,311 (205)

The relevance of sperm morphology in male infertility [PDF]

, 2022
This brief report concerns the role of human sperm morphology assessment in different fields of male infertility: basic research, genetics, assisted reproduction technologies, oxidative stress.
Collodel, G., Corsaro, R., Moretti, E., Noto, D., Signorini, C.   +4 more
core   +1 more source

Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies

Andrology, Volume 13, Issue 5, Page 1044-1064, July 2025.
Abstract Background In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle, which contains dynein motor proteins that provide the mechanical force for sperm propulsion and ...
Emma Cavarocchi, Maëva Drouault, Joao C. Ribeiro, Violaine Simon, Marjorie Whitfield, Aminata Touré   +5 more
wiley   +1 more source

Semen analysis - what a clinician should know [PDF]

, 2015
published_or_final_versio
Ho, PC, Lam, KKW, Li, RHW, Ng, EHY, Yeung, WSB   +4 more
core  

Fine mapping of meiotic NAHR-associated crossovers causing large NF1 deletions [PDF]

, 2015
Large deletions encompassing the NF1 gene and its flanking regions belong to the group of genomic disorders caused by copy number changes that are mediated by the local genomic architecture. Although nonallelic homologous recombination (NAHR) is known to
Cooper, David Neil, Daiber, Michaela, Hillmer, Morten, Kehrer-Sawatzki, Hildegard, Mautner, Victor-Felix, Messiaen, Ludwine, Summerer, Anna, Wagner, David   +7 more
core   +1 more source

Novel variations in TENT5D lead to teratozoospermia in infertile patients

Andrology, Volume 12, Issue 6, Page 1336-1346, September 2024.
Abstract Purpose Teratozoospermia is the main pathogenic factor of male infertility. However, the genetic etiology of teratozoospermia is largely unknown. This study aims to clarify the relationship between novel variations in TENT5D and teratozoospermia in infertile patients. Materials and methods Two infertile patients were enrolled.
Ying‐Teng Zhang, Gan Shen, Liang‐Chai Zhuo, Xue Yang, Su‐Yan Wang, Tie‐Chao Ruan, Chuan Jiang, Xiang Wang, Yan Wang, Yi‐Hong Yang, Ying Shen   +10 more
wiley   +1 more source

Chromosome aneuploidy in the spermatozoa of two men with globozoospermia [PDF]

MHR: Basic science of reproductive medicine, 2004
The objective of this study was to determine the aneuploidy level in spermatozoa in two men with globozoospermia. Sperm nuclei were analysed by fluorescence in-situ hybridization (FISH) in two infertile males with globozoospermia. Dual FISH for chromosomes 7 and 9, 13 and 21, and triple FISH for chromosomes X, Y, and 18 was performed.
F, Morel, N, Douet-Guilbert, A, Moerman, B, Duban, C, Marchetti, B, Delobel, M-J, Le Bris, V, Amice, M, De Braekeleer   +8 more
openaire   +2 more sources

Sperm morphology: Evaluating its clinical relevance in contemporary fertility practice

Reproductive Medicine and Biology, Volume 23, Issue 1, January/December 2024.
Abstract Background The World Health Organization (WHO) recommends reporting sperm morphology in a standard semen analysis. However, the clinical utility and prognostic value of morphology is often debated. Methods We reviewed and summarized studies that assessed both the benefits and limitations of sperm morphology in the context of natural fertility,
Daniel L. Pelzman, Jay I. Sandlow
wiley   +1 more source

Essential role for SUN5 in anchoring sperm head to the tail

eLife, 2017
SUN (Sad1 and UNC84 domain containing)-domain proteins are reported to reside on the nuclear membrane playing distinct roles in nuclear dynamics. SUN5 is a new member of the SUN family, with little knowledge regarding its function.
Yongliang Shang, Fuxi Zhu, Lina Wang, Ying-Chun Ouyang, Ming-Zhe Dong, Chao Liu, Haichao Zhao, Xiuhong Cui, Dongyuan Ma, Zhiguo Zhang, Xiaoyu Yang, Yueshuai Guo, Feng Liu, Li Yuan, Fei Gao, Xuejiang Guo, Qing-Yuan Sun, Yunxia Cao, Wei Li   +18 more
doaj   +1 more source

Deleterious genetic changes in AGTPBP1 result in teratozoospermia with sperm head and flagella defects

Journal of Cellular and Molecular Medicine, Volume 28, Issue 2, January 2024.
Abstract Approximately 10%–15% of couples worldwide are infertile, and male factors account for approximately half of these cases. Teratozoospermia is a major cause of male infertility. Although various mutations have been identified in teratozoospermia, these can vary among ethnic groups.
Yu‐Hua Lin, Ya‐Yun Wang, Tsung‐Hsuan Lai, Jih‐Lung Teng, Chi‐Wei Lin, Chih‐Chun Ke, I‐Shing Yu, Hui‐Ling Lee, Chying‐Chyuan Chan, Chi‐Hua Tung, Donald F. Conrad, Moira K. O'Bryan, Ying‐Hung Lin   +12 more
wiley   +1 more source

The LINC complex component Sun4 plays a crucial role in sperm head formation and fertility

Biology Open, 2015
LINC complexes are evolutionarily conserved nuclear envelope bridges, physically connecting the nucleus to the peripheral cytoskeleton. They are pivotal for dynamic cellular and developmental processes, like nuclear migration, anchoring and positioning ...
Elisabeth Pasch, Jana Link, Carolin Beck, Stefanie Scheuerle, Manfred Alsheimer   +4 more
doaj   +1 more source