Results 91 to 100 of about 2,192 (198)

Globozoospermia is mainly due to DPY19L2 deletion via non-allelic homologous recombination involving two recombination hotspots

, 2012
To date, mutations in two genes, SPATA16 and DPY19L2, have been identified as responsible for a severe teratozoospermia, namely globozoospermia. The two initial descriptions of the DPY19L2 deletion lead to a very different rate of occurrence of this ...
Viville, Stéphane, Gourabi, H, Louanjli, Noureddine, Oehninger, Sergio, Deemeh, Mohammad, Iqbal, Naeem, Bisharah, Mazen, De Sutter, Petra, Brugnon, Florence, Ben Khalifa, Moncef, Modarres, Parastoo, Ellnati, Elias, Muller, Jean, Jaber, Sara, Carré Pigeon, Frédérique, Gourabi, H., Oehninger, Sergio C, Elinati, Elias, Grillo, Jean-Marc, Pigeon, Frédérique Carré, Kuentz, Paul, Demirol, Aygul, Gurgan, Timur, Nikiforaki, Dimitra, Makarian, Joelle, Ghaedi, Kamran, Tanhaei, Somayeh, Deemeh, Mohammad R, Nasr-Esfahani, Mohammad, Nasr-Esfahani, Mohammad H, Gitlin, Susan, Redin, Claire, Koscinski, Isabelle, Gitlin, Susan A, Vanden Meerschaut, Frauke, De Briel, Dominique, Heindryckx, Björn, Benkhalifa, Moncef   +37 more
core   +1 more source

Deleterious genetic changes in AGTPBP1 result in teratozoospermia with sperm head and flagella defects

Journal of Cellular and Molecular Medicine, Volume 28, Issue 2, January 2024.
Abstract Approximately 10%–15% of couples worldwide are infertile, and male factors account for approximately half of these cases. Teratozoospermia is a major cause of male infertility. Although various mutations have been identified in teratozoospermia, these can vary among ethnic groups.
Yu‐Hua Lin, Ya‐Yun Wang, Tsung‐Hsuan Lai, Jih‐Lung Teng, Chi‐Wei Lin, Chih‐Chun Ke, I‐Shing Yu, Hui‐Ling Lee, Chying‐Chyuan Chan, Chi‐Hua Tung, Donald F. Conrad, Moira K. O'Bryan, Ying‐Hung Lin   +12 more
wiley   +1 more source

Pathoproteomics of testicular tissue deficient in the GARP component VPS54: The wobbler mouse model of globozoospermia [PDF]

, 2014
In human globozoospermia, round-headed spermatozoa lack an acrosome and therefore cannot properly interact with oocytes. In the wobbler (WR) mouse, an L967Q missense mutation in the vesicular protein-sorting factor VPS54 causes motor neuron ...
Staunton, Lisa, Schmitt-John, Thomas, Ashling Holland, Ohlendiek, K, Holland, Ashling, Ohlendieck, Kay, Harald Jockusch, Heimann, Peter, Holland, A, Staunton, L, Dowling, Paul, Thomas Schmitt‐John, Lisa Staunton, Schmidt-John, T, Kay Ohlendieck, Peter Heimann, Paul Dowling, Jockusch, Harald, Dowling, P   +18 more
core   +1 more source

Implementation of World Health Organization Recommendations for Semen Analysis: A Survey of Laboratories in the United Kingdom

Andrologia, Volume 2024, Issue 1, 2024.
The standard method for identification of male fertility status is a semen analysis. This is performed in fertility and pathology laboratories accredited by different bodies in the UK such as the HFEA or UKAS, and is based on whether they perform licenced clinical treatment or diagnostic testing.
Lisa M Bosman, Iulia A Grosu, Peter J Ellis, Darren K Griffin, Sheryl T Homa, Marta Olszewska   +5 more
wiley   +1 more source

Evaluation of PLCζ and PAWP Expression in Globozoospermic Individuals

Cell Journal, 2016
Objective: Globozoospermia is a rare type of teratozoospermia with incidence of 0.1% among infertile individuals. Phospholipase C zeta (PLCζ) and postacrosomal sheath WW domain binding protein (PAWP) are the main candidates in sperm taking ...
Majid Kamali-Dolat Abadi, Marziyeh Tavalaee, Abdolhossein Shahverdi, Mohammad Hossein Nasr-Esfahani   +3 more
doaj  

Two Siblings With Complete Globozoospermia

, 2008
Although globozoospermia (round-headed spermatozoa) is encountered as 0.1% of the infertile population, familial appearance of globozoospermia is extremely limited. In this report, we aimed to describe two male siblings of 26 and 45 years of age with the
Demir, Bulent, Gunalp, Serdar, BOZDAĞ, GÜRKAN   +2 more
core  

Kdm3a lysine demethylase is an Hsp90 client required for cytoskeletal rearrangements during spermatogenesis [PDF]

, 2014
The lysine demethylase Kdm3a (Jhdm2a, Jmjd1a) is required for male fertility, sex determination, and metabolic homeostasis through its nuclear role in chromatin remodeling.
Kasioulis, Ioannis, Jackson, Ian J., Botting, C. H., Botting, Catherine H., Kasioulis, I., Syred, H. M., Seawright, Anne, Fuszard, Matthew Alexander, Shirran, Sally, Van Heyningen, V., Tate, Peri, Finch, Andrew, Tate, P., Jackson, I. J., Adams, I. R., Syred, Heather M., Finch, A., Yeyati, P. L., Shaw, J., Shirran, S., Fuszard, M., Adams, Ian R., Shaw, Joseph, Seawright, A., Yeyati, Patricia L., van Heyningen, Veronica   +25 more
core   +1 more source

Assessment of Sperm DNA Fragmentation in Patients with Partial

مجله دانشکده پزشکی اصفهان, 2015
Background: Infertility is estimated to affect up to 15% of couples of reproductive age. Globozoospermia is a rare (incidence < 0.1%) but severe disorder in male infertility.
Fereshteh Rasouli, Marjan sabbaghian, Mohammad Ali Sadighi-Gilani, Ramesh Monajemi   +3 more
doaj  

Mouse DCUN1D1 (SCCRO) is required for spermatogenetic individualization.

PLoS ONE, 2019
Squamous cell carcinoma-related oncogene (SCCRO, also known as DCUN1D1) is a component of the E3 for neddylation. As such, DCUN1D1 regulates the neddylation of cullin family members.
Guochang Huang, Andrew J Kaufman, Russell J H Ryan, Yevgeniy Romin, Laryssa Huryn, Sarina Bains, Katia Manova-Todorova, Patricia L Morris, Gary R Hunnicutt, Carrie A Adelman, John H J Petrini, Y Ramanathan, Bhuvanesh Singh   +12 more
doaj   +1 more source

Successful pregnancy in globozoospermia with severe oligoasthenospermia after ICSI

Journal of Obstetrics and Gynaecology, 2010
Globozoospermia is a severe form of teratozoospermia characterised by round-headed acrosomeless spermatozoa (Castellani et al.
B, Sahu, O, Ozturk, P, Serhal
openaire   +2 more sources