Mechanism of Acrosome Biogenesis in Mammals [PDF]
Frontiers in Cell and Developmental Biology, 2019 During sexual reproduction, two haploid gametes fuse to form the zygote, and the acrosome is essential to this fusion process (fertilization) in animals.
Muhammad Babar Khawar +1 more
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Ubiquitin Ligase Nrdp1 Controls Autophagy-Associated Acrosome Biogenesis and Mitochondrial Arrangement during Spermiogenesis [PDF]
Cells, 2023 Autophagy is critical to acrosome biogenesis and mitochondrial quality control, but the underlying mechanisms remain unclear. The ubiquitin ligase Nrdp1/RNF41 promotes ubiquitination of the mitophagy-associated Parkin and interacts with the pro ...
Tian-Xia Jiang, Xiao-Bo Qiu
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Loss of Profilin3 Impairs Spermiogenesis by Affecting Acrosome Biogenesis, Autophagy, Manchette Development and Mitochondrial Organization [PDF]
Frontiers in Cell and Developmental Biology, 2021 Profilins (PFNs) are key regulatory proteins for the actin polymerization in cells and are encoded in mouse and humans by four Pfn genes. PFNs are involved in cell mobility, cell growth, neurogenesis, and metastasis of tumor cells.
Lena Arévalo +2 more
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The Slingshot phosphatase 2 is required for acrosome biogenesis during spermatogenesis in mice [PDF]
eLife, 2023 The acrosome is a membranous organelle positioned in the anterior portion of the sperm head and is essential for male fertility. Acrosome biogenesis requires the dynamic cytoskeletal shuttling of vesicles toward nascent acrosome which is regulated by a ...
Ke Xu +17 more
doaj +4 more sources
Loss of CEP70 function affects acrosome biogenesis and flagella formation during spermiogenesis [PDF]
Cell Death and Disease, 2021 The spermatogenesis process is complex and delicate, and any error in a step may cause spermatogenesis arrest and even male infertility. According to our previous transcriptomic data, CEP70 is highly expressed throughout various stages of human ...
Qiang Liu +8 more
doaj +5 more sources
WDR38, a novel equatorial segment protein, interacts with the GTPase protein RAB19 and Golgi protein GM130 to play roles in acrosome biogenesis [PDF]
Acta Biochimica et Biophysica Sinica, 2023 The WD40-repeat containing (WDR) proteins are enriched in the testis and play important roles in spermatogenesis. In the present study, we investigate the expression profile of WDR38, a novel member of the WDR ...
Gao Qiujie +6 more
doaj +3 more sources
TMC7 deficiency causes acrosome biogenesis defects and male infertility in mice [PDF]
eLifeTransmembrane channel-like (TMC) proteins are a highly conserved ion channel family consisting of eight members (TMC1–TMC8) in mammals. TMC1/2 are components of the mechanotransduction channel in hair cells, and mutations of TMC1/2 cause deafness in ...
Jing Wang +12 more
doaj +4 more sources
FAM209 associates with DPY19L2, and is required for sperm acrosome biogenesis and fertility in mice [PDF]
Journal of Cell Science, 2021 ABSTRACT Infertility afflicts up to 15% of couples globally each year with men a contributing factor in 50% of these cases. Globozoospermia is a rare condition found in infertile men, which is characterized by defective acrosome biogenesis leading to the production of round-headed sperm.
Julio M Castaneda +2 more
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Expression of Flotilin-2 and Acrosome Biogenesis Are Regulated by MiR-124 during Spermatogenesis. [PDF]
PLoS ONE, 2015 MicroRNAs (miRNAs) are a class of short non-coding RNA molecules, which diversely regulate gene expression in organisms. Although the regulatory role of these small RNA molecules has been recently explored in animal spermatogenesis, the role of miR-124 ...
Yibo Wu +7 more
doaj +5 more sources
Atg7 is required for acrosome biogenesis during spermatogenesis in mice [PDF]
Cell Research, 2014 The acrosome is a specialized organelle that covers the anterior part of the sperm nucleus and plays an essential role in the process of fertilization. The molecular mechanism underlying the biogenesis of this lysosome-related organelle (LRO) is still largely unknown.
Haifeng Wan, Weixiao Liu, Yaqing Wang
exaly +5 more sources