Mechanism of Acrosome Biogenesis in Mammals [PDF]
Frontiers in Cell and Developmental Biology, 2019 During sexual reproduction, two haploid gametes fuse to form the zygote, and the acrosome is essential to this fusion process (fertilization) in animals.
Muhammad Babar Khawar, Wei Li
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Ubiquitin Ligase Nrdp1 Controls Autophagy-Associated Acrosome Biogenesis and Mitochondrial Arrangement during Spermiogenesis [PDF]
Cells, 2023 Autophagy is critical to acrosome biogenesis and mitochondrial quality control, but the underlying mechanisms remain unclear. The ubiquitin ligase Nrdp1/RNF41 promotes ubiquitination of the mitophagy-associated Parkin and interacts with the pro ...
Tian-Xia Jiang, Xiao-Bo Qiu
exaly +6 more sources
Loss of Profilin3 Impairs Spermiogenesis by Affecting Acrosome Biogenesis, Autophagy, Manchette Development and Mitochondrial Organization [PDF]
Frontiers in Cell and Developmental Biology, 2021 Profilins (PFNs) are key regulatory proteins for the actin polymerization in cells and are encoded in mouse and humans by four Pfn genes. PFNs are involved in cell mobility, cell growth, neurogenesis, and metastasis of tumor cells.
Lena Lüke, Walter Witke, Hubert Schorle
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The Slingshot phosphatase 2 is required for acrosome biogenesis during spermatogenesis in mice [PDF]
eLife, 2023 The acrosome is a membranous organelle positioned in the anterior portion of the sperm head and is essential for male fertility. Acrosome biogenesis requires the dynamic cytoskeletal shuttling of vesicles toward nascent acrosome which is regulated by a ...
Ke Xu +17 more
doaj +4 more sources
Loss of CEP70 function affects acrosome biogenesis and flagella formation during spermiogenesis [PDF]
Cell Death and Disease, 2021 The spermatogenesis process is complex and delicate, and any error in a step may cause spermatogenesis arrest and even male infertility. According to our previous transcriptomic data, CEP70 is highly expressed throughout various stages of human ...
Qiang Liu +8 more
doaj +5 more sources
TMC7 deficiency causes acrosome biogenesis defects and male infertility in mice [PDF]
eLifeTransmembrane channel-like (TMC) proteins are a highly conserved ion channel family consisting of eight members (TMC1–TMC8) in mammals. TMC1/2 are components of the mechanotransduction channel in hair cells, and mutations of TMC1/2 cause deafness in ...
Jing Wang +12 more
doaj +4 more sources
WDR38, a novel equatorial segment protein, interacts with the GTPase protein RAB19 and Golgi protein GM130 to play roles in acrosome biogenesis [PDF]
Acta Biochimica et Biophysica Sinica, 2023 The WD40-repeat containing (WDR) proteins are enriched in the testis and play important roles in spermatogenesis. In the present study, we investigate the expression profile of WDR38, a novel member of the WDR ...
Gao Qiujie +6 more
doaj +3 more sources
Differential Expression and Localization of EHBP1L1 during the First Wave of Rat Spermatogenesis Suggest Its Involvement in Acrosome Biogenesis [PDF]
Biomedicines, 2022 The identification and characterization of new proteins involved in spermatogenesis is fundamental, considering that good-quality gametes are basic in ensuring proper reproduction.
Massimo Venditti, Sergio Minucci
exaly +4 more sources
Expression of Flotilin-2 and Acrosome Biogenesis Are Regulated by MiR-124 during Spermatogenesis. [PDF]
PLoS ONE, 2015 MicroRNAs (miRNAs) are a class of short non-coding RNA molecules, which diversely regulate gene expression in organisms. Although the regulatory role of these small RNA molecules has been recently explored in animal spermatogenesis, the role of miR-124 ...
Yibo Wu +7 more
doaj +5 more sources
ELAPOR1 mediated vesicle traffic is required for acrosome biogenesis and male fertility in mice [PDF]
Cellular and Molecular Life SciencesSpermiogenesis is the post-meiotic differentiation and morphological change of the haploid spermatids. Acrosome biogenesis is one of the key events of spermiogenesis, which generates a specialized membranous organelle crucial for shaping the balanced ...
Runze Ding +7 more
doaj +2 more sources