AU040320 deficiency leads to disruption of acrosome biogenesis and infertility in homozygous mutant mice. [PDF]
Sci Rep, 2018 AbstractStudy of knockout (KO) mice has helped understand the link between many genes/proteins and human diseases. Identification of infertile KO mice provides valuable tools to characterize the molecular mechanisms underlying gamete formation. The KIAA0319L gene has been described to have a putative association with dyslexia; surprisingly, we observed
Guidi LG +6 more
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Testis-specific lncRNA Teshl regulates acrosome biogenesis to maintain sperm structure and function [PDF]
Cell & BioscienceBackground The testis exhibits the highest tissue-specific gene expression of all organs, including both coding and non-coding genes. Our previous study reported that Teshl, a testis-specific long noncoding RNA, associates with heat shock factor 2 (HSF2),
Seung Pyo Hong +5 more
doaj +2 more sources
The molecular mechanisms underlying acrosome biogenesis elucidated by gene-manipulated mice†
Biology of Reproduction, 2021 AbstractSexual reproduction requires the fusion of two gametes in a multistep and multifactorial process termed fertilization. One of the main steps that ensures successful fertilization is acrosome reaction. The acrosome, a special kind of organelle with a cap-like structure that covers the anterior portion of sperm head, plays a key role in the ...
Wenfeng Xiong +2 more
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Acrosome biogenesis begins during meiosis: evidence from the synthesis and distribution of an acrosomal glycoprotein, acrogranin, during guinea pig spermatogenesis [PDF]
Biology of Reproduction, 1990 The biogenesis of the sperm-specific organelle, the acrosome, was investigated using an acrosomal glycoprotein as a marker of development. This component, which we have named acrogranin, was purified from an acid extract of guinea pig testes by standard chromatographic procedures.
George L Gerton, Gerton George L
exaly +3 more sources
European Journal of Cell Biology, 2009 The N-terminal BAR domain of endophilin has unique functions, such as affecting the curvature of the lipid membrane through its lysophosphatidic acid acyltransferase activity, binding of ATP and GTP and participating in tubulating activity. We recently demonstrated that SH3P13, a BAR domain-containing protein, assists in regulating clathrin-coated ...
Shiying Miao
exaly +3 more sources
Role of microtubule-dependent membrane trafficking in acrosomal biogenesis [PDF]
Cell and Tissue Research, 2005 The role of microtubule-based trafficking in acrosomal biogenesis was examined by studying the effects of colchicine on spermiogenesis. In electron micrographs of untreated cap-phase mouse spermatids, coated vesicles were always seen on the apex and caudal margins of the developing acrosomal cap. The increase in volume and the accumulation of materials
Wei-Pang, Huang, Han-Chen, Ho
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Dynamics of Sun5 localization during spermatogenesis in wild type and Dpy19l2 knock-out mice indicates that Sun5 is not involved in acrosome attachment to the nuclear envelope. [PDF]
PLoS ONE, 2015 The acrosome is an organelle that is central to sperm physiology and a defective acrosome biogenesis leads to globozoospermia, a severe male infertility. The identification of the actors involved in acrosome biogenesis is therefore particularly important
Sandra Yassine +6 more
doaj +1 more source
Acrosomal biogenesis in human globozoospermia: immunocytochemical, ultrastructural and proteomic studies [PDF]
Human Reproduction, 2012 Acrosome biogenesis is a key event in sperm differentiation that depends on the proper interaction between the Golgi complex and the nuclear envelope of early spermatids. We studied the development, structure and biochemical characteristics of human acrosomes in germ cells and spermatozoa from testicular biopsies and semen samples of fertile men and ...
Alvarez Sedó, Cristian +2 more
openaire +3 more sources
Inceptor facilitates acrosomal vesicle formation in spermatids and is required for male fertility
Frontiers in Cell and Developmental Biology, 2023 Spermatogenesis is a crucial biological process that enables the production of functional sperm, allowing for successful reproduction. Proper germ cell differentiation and maturation require tight regulation of hormonal signals, cellular signaling ...
Sara Bilekova +18 more
doaj +1 more source
Arrdc4‐dependent extracellular vesicle biogenesis is required for sperm maturation
Journal of Extracellular Vesicles, 2021 Extracellular vesicles (EVs) are important players in cell to cell communication in reproductive systems. Notably, EVs have been found and characterized in the male reproductive tract, however, direct functional evidence for their importance in mediating
Natalie J. Foot +10 more
doaj +1 more source