Dynamics of Sun5 localization during spermatogenesis in wild type and Dpy19l2 knock-out mice indicates that Sun5 is not involved in acrosome attachment to the nuclear envelope. [PDF]
PLoS ONE, 2015 The acrosome is an organelle that is central to sperm physiology and a defective acrosome biogenesis leads to globozoospermia, a severe male infertility. The identification of the actors involved in acrosome biogenesis is therefore particularly important
Sandra Yassine +6 more
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Testicular expression of TDRD1, TDRD5, TDRD9 and TDRD12 in azoospermia. [PDF]
, 2020 BACKGROUND: Tudor domain-containing proteins (TDRDs) play a critical role in piRNA biogenesis and germ cell development. piRNAs, small regulatory RNAs, act by silencing of transposons during germline development and it has recently been shown in animal ...
Aghaei, M +9 more
core +1 more source
Role of microtubule-dependent membrane trafficking in acrosomal biogenesis [PDF]
Cell and Tissue Research, 2005 The role of microtubule-based trafficking in acrosomal biogenesis was examined by studying the effects of colchicine on spermiogenesis. In electron micrographs of untreated cap-phase mouse spermatids, coated vesicles were always seen on the apex and caudal margins of the developing acrosomal cap. The increase in volume and the accumulation of materials
Wei-Pang, Huang, Han-Chen, Ho
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Inceptor facilitates acrosomal vesicle formation in spermatids and is required for male fertility
Frontiers in Cell and Developmental Biology, 2023 Spermatogenesis is a crucial biological process that enables the production of functional sperm, allowing for successful reproduction. Proper germ cell differentiation and maturation require tight regulation of hormonal signals, cellular signaling ...
Sara Bilekova +18 more
doaj +1 more source
Acrosomal biogenesis in human globozoospermia: immunocytochemical, ultrastructural and proteomic studies [PDF]
Human Reproduction, 2012 Acrosome biogenesis is a key event in sperm differentiation that depends on the proper interaction between the Golgi complex and the nuclear envelope of early spermatids. We studied the development, structure and biochemical characteristics of human acrosomes in germ cells and spermatozoa from testicular biopsies and semen samples of fertile men and ...
Alvarez Sedó, Cristian +2 more
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Arrdc4‐dependent extracellular vesicle biogenesis is required for sperm maturation
Journal of Extracellular Vesicles, 2021 Extracellular vesicles (EVs) are important players in cell to cell communication in reproductive systems. Notably, EVs have been found and characterized in the male reproductive tract, however, direct functional evidence for their importance in mediating
Natalie J. Foot +10 more
doaj +1 more source
The molecular mechanisms underlying acrosome biogenesis elucidated by gene-manipulated mice†
Biology of Reproduction, 2021 AbstractSexual reproduction requires the fusion of two gametes in a multistep and multifactorial process termed fertilization. One of the main steps that ensures successful fertilization is acrosome reaction. The acrosome, a special kind of organelle with a cap-like structure that covers the anterior portion of sperm head, plays a key role in the ...
Wenfeng, Xiong +2 more
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The role of acroblast formation during Drosophila spermatogenesis [PDF]
, 2016 Protein recycling is important for maintaining homeostasis of the Golgi and its cisternae. The Vps54 (Scat) protein, a subunit of the GARP tethering complex, is a central factor in retrograde transport to the trans-Golgi.
Fari, Karolina +3 more
core +9 more sources
An Overview of The Globozoospermia as A Multigenic Identified Syndrome [PDF]
International Journal of Fertility and Sterility, 2019 Acrosome plays an integral role during fertilization and its absence in individuals with globozoospermia leads to failure of in vitro fertilization (IVF) and oocyte activation post-intracytoplasmic sperm injection (ICSI).
Parastoo Modarres +2 more
doaj +1 more source
Loss of Zona Pellucida Binding Proteins in the Acrosomal Matrix Disrupts Acrosome Biogenesis and Sperm Morphogenesis [PDF]
Molecular and Cellular Biology, 2007 Zona pellucida binding protein 1 (ZPBP1), a spermatid and spermatozoon protein that localizes to the acrosome, was originally identified in pigs and named for its binding to the oocyte zona pellucida. In an in silico search for germ cell-specific genes, Zpbp1 and its novel paralog, Zpbp2, were discovered and confirmed to be expressed only in the testes
Yi-Nan, Lin +4 more
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