EIF5A Couples Translational Control With Transcriptional Reprogramming Through Chromocenter Reorganization During Spermiogenesis. [PDF]
Adv Sci (Weinh)The translation factor Eukaryotic translation initiation factor 5A (eIF5A) is essential for male fertility in mice. It supports the translation of proteins crucial for heterochromatin organization and acrosome formation. eIF5A deficiency disrupts chromocenter integrity, increases chromatin accessibility, and causes transcriptional dysregulation ...
Cai Y +15 more
europepmc +2 more sources
Condensed Mitochondria Assemble Into the Acrosomal Matrix During Spermiogenesis
Frontiers in Cell and Developmental Biology, 2022 Mammalian spermatogenesis is associated with the transient appearance of condensed mitochondria, a singularity of germ cells with unknown function.
Mindong Ren +11 more
doaj +1 more source
The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity [PDF]
, 2017 Transposable elements (TEs) contribute to the large amount of repetitive sequences in mammalian genomes and have been linked to species-specific genome innovations by rewiring regulatory circuitries.
Ernst, C, Kutter, Claudia, Odom, Duncan
core +2 more sources
Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse. [PDF]
PLoS ONE, 2013 PRAME belongs to a group of cancer/testis antigens (CTAs) that are characterized by their restricted expression in normal gametogenic tissues and a variety of tumors.
Bhavesh V Mistry +7 more
doaj +1 more source
Circadian desynchrony disturbs the function of rat spermatozoa
European Journal of Cell Biology, 2023 Decreased male fertility is a growing health problem that requires a better understanding of molecular events regulating reproductive competence. Here the effects of circadian desynchrony on the rat spermatozoa functionality were studied.
Dijana Z. Travicic +7 more
doaj +1 more source
Sperm specific proteins-potential candidate molecules for fertility control [PDF]
, 2004 The increase in population growth rate warrants the development of additional contraceptive methods that are widely acceptable, free from side effects and less expensive.
Suri Anil
core +2 more sources
Partial Deletion of Chromosome 8 β-defensin Cluster Confers Sperm Dysfunction and Infertility in Male Mice [PDF]
, 2013 β-defensin peptides are a family of antimicrobial peptides present at mucosal surfaces, with the main site of expression under normal conditions in the male reproductive tract.
A Krutskikh +59 more
core +5 more sources
Involvement of sperm acetylated histones and the nuclear isoform of Glutathione peroxidase 4 in fertilization [PDF]
, 2017 We previously demonstrated that the nuclear form of Glutathione peroxidase 4 (nGPx4) has a peculiar distribution in sperm head, being localized to nuclear matrix and acrosome and that sperm lacking nGPx4 are more prone to decondensation in vitro. In this
Boitani, Carla +8 more
core +1 more source
Small RNA sequencing of cryopreserved semen from single bull revealed altered miRNAs and piRNAs expression between High- and Low-motile sperm populations [PDF]
, 2017 Putative piRNA clusters that were assigned by proTRAC to the High Motile (HM) and Low Motile (LM) sperm fractions.
A. Stella +7 more
core +9 more sources
Redox Biology, 2021 Fibrous sheath interacting protein 1 (Fsip1) is a cytoskeletal structural protein of the sperm flagellar proteome. A few studies have reported that it plays a vital role in the tumorigenesis and cancer progression. However, little is known about the role
Yaser Gamallat +14 more
doaj +1 more source