Results 41 to 50 of about 1,969 (137)

Circadian desynchrony disturbs the function of rat spermatozoa

European Journal of Cell Biology, 2023
Decreased male fertility is a growing health problem that requires a better understanding of molecular events regulating reproductive competence. Here the effects of circadian desynchrony on the rat spermatozoa functionality were studied.
Dijana Z. Travicic, Maja V. Pavlovic, Marija L.J. Medar, Alisa Becin, Mia Cetnik, Dusan Lalosevic, Silvana A. Andric, Tatjana S. Kostic   +7 more
doaj   +1 more source

Bi-allelic mutation in Fsip1 impairs acrosome vesicle formation and attenuates flagellogenesis in mice

Redox Biology, 2021
Fibrous sheath interacting protein 1 (Fsip1) is a cytoskeletal structural protein of the sperm flagellar proteome. A few studies have reported that it plays a vital role in the tumorigenesis and cancer progression. However, little is known about the role
Yaser Gamallat, Xiang Fang, Hanran Mai, Xiaonan Liu, Hong Li, Pei Zhou, Dingding Han, Shuxin Zheng, Caihua Liao, Miaomiao Yang, Yan Li, Liandong Zuo, Ling Sun, Hao Hu, Na Li   +14 more
doaj   +1 more source

Zbtb40 Deficiency Leads to Morphological and Phenotypic Abnormalities of Spermatocytes and Spermatozoa and Causes Male Infertility

Cells, 2023
Studies on the gene regulation of spermatogenesis are of unusual significance for maintaining male reproduction and treating male infertility. Here, we have demonstrated, for the first time, that a loss of ZBTB40 function leads to abnormalities in the ...
Yinghong Cui, Mingqing Zhou, Quanyuan He, Zuping He   +3 more
doaj   +1 more source

Physiological role of actin regulation in male fertility: Insight into actin capping proteins in spermatogenic cells

Reproductive Medicine and Biology, 2020
Background During spermatogenesis, cytoskeletal elements are essential for spermatogenic cells to change morphologically and translocate in the seminiferous tubule.
Tetsuji Soda, Yasushi Miyagawa, Shinichiro Fukuhara, Hiromitsu Tanaka   +3 more
doaj   +1 more source

Integration of omics studies indicates that species-dependent molecular mechanisms govern male fertility

Journal of Animal Science and Biotechnology, 2023
Background Comparative and comprehensive omics studies have recently been conducted to provide a comprehensive understanding of the biological mechanisms underlying infertility.
Yoo-Jin Park, Won-Ki Pang, Myung-Geol Pang   +2 more
doaj   +1 more source

Biogenesis of sperm acrosome is regulated by pre-mRNA alternative splicing ofAcrbpin the mouse [PDF]

Proceedings of the National Academy of Sciences, 2016
SignificanceMammalian sperm possess a Golgi-derived exocytotic organelle, the acrosome, located on the apical region of the head. Proper biogenesis of the acrosome is essential for the fertilization process because the aberrant acrosome formation results in the sterility or subfertility of males. Here, we show that the acrosome formation is governed by
Yoshinori, Kanemori, Yoshitaka, Koga, Mai, Sudo, Woojin, Kang, Shin-Ichi, Kashiwabara, Masahito, Ikawa, Hidetoshi, Hasuwa, Kiyoshi, Nagashima, Yu, Ishikawa, Narumi, Ogonuki, Atsuo, Ogura, Tadashi, Baba   +11 more
openaire   +2 more sources

Fundamental Mechanisms of Sperm Production: The Role of Microtubules

Fertility & Reproduction, 2023
Spermatogenesis is a feat of unparalleled biological scale and complexity. At any one time, the human testis harbours millions of germ cells in a continuous progression through multiple rounds of mitosis and meiosis, followed by a series of dramatic ...
Jessica Dunleavy
doaj   +1 more source

The use of deidentified organ donor testes for research

Andrology, EarlyView.
Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova, Marnie W. Skinner, Juliana I. Candelaria, Stephen R. Wellard, Philip W. Jordan   +4 more
wiley   +1 more source

The Mechanism of Heat Stress Resistance During Spermatogenesis in Turpan Black Sheep

Frontiers in Veterinary Science, 2022
Heat stress can affect the reproductive function of livestock and cause harm to animal production, which can seriously damage the economic interests of livestock producers.
Yukun Song, Xi Zhao, Aikebaier Aihemaiti, Aerman Haire, Yu Gao, Chao Niu, Peng Yang, Guoshi Liu, Gongxue Jia, Abulizi Wusiman   +9 more
doaj   +1 more source

Testicular SIRT1 Loss Reveals an Aging‐Like Proteomic Landscape and Precipitates Reproductive Deterioration

Andrology, EarlyView.
ABSTRACT Background Advanced paternal age is associated with reduced male fertility and testicular dysfunction. Among the molecular regulators involved in aging, SIRT1, a NAD+‐dependent deacetylase, plays a pivotal role in maintaining oxidative balance and cellular homeostasis.
María Iniesta‐Cuerda, Jiřina Havránková, Hedvika Řimnáčová, Jiří Moravec, František Liška, Martin Knytl, Milena Králíčková, Jan Nevoral   +7 more
wiley   +1 more source