Results 61 to 70 of about 3,330 (184)
Characterization of the functions and proteomes associated with membrane rafts in chicken sperm [PDF]
, 2017 Cellular membranes are heterogeneous, and this has a great impact on cellular function. Despite the central role of membrane functions in multiple cellular processes in sperm, their molecular mechanisms are poorly understood.
Asano Atsushi +6 more
core +1 more source
Andrology, EarlyView.ABSTRACT Background Extracellular vesicles (EVs) produced by accessory sex glands play a key role in sperm functionality, influencing motility, viability, acrosome integrity, metabolic activity, and capacitation. Most studies on the effects of EVs on spermatozoa have focused on ejaculated spermatozoa, which have already been exposed to their own native
Ana Moya‐Fernández +4 more
wiley +1 more source
Ecotoxicology and Environmental SafetyPerfluorooctanoic acid (PFOA) is a reproductive toxicant, but its effects on sperm head shaping and acrosome reaction remain unknown. Adult male Bal b/c mice were given 0, 2 or 10 mg/kg/day of PFOA for 6 weeks by gavage. Elevated sperm head malformations
Chuan Wang +9 more
doaj +1 more source
Inhibition of ovine in vitro fertilization by anti-Prt antibody: hypothetical model for Prt/ZP interaction [PDF]
, 2013 BACKGROUND: The impact of prion proteins in the rules that dictate biological reproduction is still poorly understood. Likewise, the role of prnt gene, encoding the prion-like protein testis specific (Prt), in ram reproductive physiology remains largely ...
Aldino Viegas +15 more
core +1 more source
Andrology, EarlyView.ABSTRACT Background Advanced paternal age is associated with reduced male fertility and testicular dysfunction. Among the molecular regulators involved in aging, SIRT1, a NAD+‐dependent deacetylase, plays a pivotal role in maintaining oxidative balance and cellular homeostasis.
María Iniesta‐Cuerda +7 more
wiley +1 more source
, 2015 Alternative splicing of precursor messenger RNA (pre-mRNA) is common in mammalian cells and enables the production of multiple gene products from a single gene, thus increasing transcriptome and proteome diversity.
Clark, Brett J +11 more
core +1 more source
Testis‐Enriched F‐Box Protein FBXO39 Is Important for Spermiogenesis and Male Fertility in Mice
Andrology, EarlyView.ABSTRACT Background The SCF (Skp–Cullin–F‐box) complex is a major class of E3 ubiquitin ligases. F‐box proteins constitute the SCF complex and play a critical role in recognizing substrates for ubiquitination. In mice, several F‐box proteins, including FBXO36 and FBXO39, are predominantly expressed in testes.
Yuki Kaneda +2 more
wiley +1 more source
piRNA-directed cleavage of meiotic transcripts regulates spermatogenesis. [PDF]
, 2015 MIWI catalytic activity is required for spermatogenesis, indicating that piRNA-guided cleavage is critical for germ cell development. To identify meiotic piRNA targets, we augmented the mouse piRNA repertoire by introducing a human meiotic piRNA cluster.
Burgess, Ralph +7 more
core +2 more sources
Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization
Advanced Science, Volume 13, Issue 26, 8 May 2026.This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin +11 more
wiley +1 more source
EMBO Molecular Medicine, 2017 Azoospermia, characterized by the absence of spermatozoa in the ejaculate, is a common cause of male infertility with a poorly characterized etiology. Exome sequencing analysis of two azoospermic brothers allowed the identification of a homozygous splice
Zine‐Eddine Kherraf +25 more
doaj +1 more source