Results 81 to 90 of about 3,330 (184)

Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility [PDF]

, 2011
Sperm structure has evolved to be very compact and compartmentalized to enable the motor (the flagellum) to transport the nuclear cargo (the head) to the egg.
Aghajanian, Haig K., Buffone, Mariano Gabriel, Cao, Wenlei, Gerton, George L., Ijiri, Takashi W., Merdiushev, Tanya   +5 more
core   +1 more source

Dad's Diet Shapes the Future: How Paternal Nutrition Impacts Placental Development and Childhood Metabolic Health

Molecular Nutrition &Food Research, Volume 69, Issue 22, November 2025.
This review highlights the emerging connection between paternal nutrition‐induced sperm epigenetic changes and placental phenotypes that may influence offspring metabolic health. An accompanying interactive ShinyApp allows exploration of these sperm–placenta gene networks, a framework for future research seeking to explore candidate biomarkers or ...
David A. Skerrett‐Byrne, Anne‐Sophie Pepin, Katharina Laurent, Johannes Beckers, Robert Schneider, Martin Hrabě de Angelis, Raffaele Teperino   +6 more
wiley   +1 more source

Extracellular Vesicles in Reproduction: Biology, Production, and Potential Applications in Livestock Breeding

Reproduction in Domestic Animals, Volume 60, Issue S3, September 2025.
ABSTRACT Extracellular Vesicles (EVs) are small, membrane‐bound particles released by cells into biological fluids, where they function as mediators of intercellular communication. These vesicles transport a diverse array of bioactive molecules, including proteins, lipids, and nucleic acids, and play essential roles in regulating physiological and ...
Alireza Fazeli, Kasun Godakumara, Suranga Kodithuwakku, Subhashini Muhandiram   +3 more
wiley   +1 more source

Strong Signatures of Selection on Candidate Genes Underlying Core Speciation Mechanisms in Desert Tortoises

Molecular Ecology Resources, Volume 25, Issue 6, August 2025.
ABSTRACT Genomic incompatibilities and differential ecological adaptation are thought to be fundamental mechanisms of speciation. In this study, we generated a chromosome‐scale reference genome and annotation for Gopherus morafkai , the Sonoran Desert tortoise, and conducted a detailed analysis of genes under positive selection with its sister species,
Sarah M. Baty, Raúl Araya‐Donoso, Avery Paulsen, Avery Williams, Dale F. DeNardo, Kenro Kusumi, Greer A. Dolby   +6 more
wiley   +1 more source

Targeting and fusion proteins during mammalian spermiogenesis

Biological Research, 2001
Regulated exocytosis is controlled by internal and external signals. The molecular machinery controlling the sorting from the newly synthesized vesicles from the Golgi apparatus to the plasma membrane play a key role in the regulation of both the number ...
JOÃO RAMALHO-SANTOS, RICARDO D. MORENO
doaj  

The sperm factor: paternal impact beyond genes [PDF]

, 2018
The fact that sperm carry more than the paternal DNA has only been discovered just over a decade ago. With this discovery, the idea that the paternal condition may have direct implications for the fitness of the offspring had to be revisited.
A Al-Khanaan, A Ashe, A Pilastro, A Soubry, AA Alcivar, AA Maklakov, AB Rodgers, AF Kahrl, AJ Crean, AJ Crean, AJ Crean, AM Brunner, AV McGrady, B Sutherland, BC Dickinson, BK Xue, BM Turner, BR Carone, BS Cox, C Allegrucci, C Ernst, C Faulk, C Klattenhof, CC Yang, CSH Young, CW Fox, D Haig, DJ Hosken, DJ Marshall, DP Bartel, DS Chu, DT Carrell, E Casas, E Zouros, EJ Richards, G Arnqvist, G Burness, GC Ostermeier, GE Dickerson, H Peng, H Schatten, J Bernardo, JB Wolf, JB Wolf, JC Perry, JE Legates, JN Wolff, JP Curley, JP Dadoune, K Gapp, KJ Merrells, KL Pixton, KM Creasey, L Arnaud, L Daxinger, L Holman, L Houri-Ze’evi, L Jiang, L Lefievre, L Lindeman, LJ Luense, LRH Illum, M Alexander, M Jodar, M Potok, MC Siomi, MF Wolfner, MJ Wade, MJG Gage, MM Patten, N Tigreros, O Rechavi, O Rechavi, P Capy, P Provataris, R Bonduriansky, R Bonduriansky, R Bonduriansky, RD Breckels, RL Willham, S Bonache, S Erkek, S Henikoff, S Immler, S Krawetz, SA Krawetz, SF Ng, SG Gu, Simone Immler, SS Hammoud, SS Hammoud, T Chapman, T Chapman, T Day, T Kouzarides, T Pizzari, T Stuart, TA Mousseau, U Brykczynska, U Sharma, VY Rawe, W Reik, X Zhao, YS Lee   +103 more
core   +1 more source

How exome sequencing improves the diagnostics and management of men with non‐syndromic infertility

Andrology, Volume 13, Issue 5, Page 1011-1024, July 2025.
Abstract Male infertility affects approximately 17% of all men and represents a complex disorder in which not only semen parameters such as sperm motility, morphology, and number of sperm are highly variable, but also testicular phenotypes range from normal spermatogenesis to complete absence of germ cells.
Birgit Stallmeyer, Ann‐Kristin Dicke, Frank Tüttelmann   +2 more
wiley   +1 more source

Phenotypic continuum and poor intracytoplasmic sperm injection intracytoplasmic sperm injection prognosis in patients harboring HENMT1 variants

Andrology, Volume 13, Issue 5, Page 1137-1148, July 2025.
Abstract Background Small RNAs interacting with PIWI (piRNAs) play a crucial role in regulating transposable elements and translation during spermatogenesis and are essential in male germ cell development. Disruptions in the piRNA pathway typically lead to severe spermatogenic defects and thus male infertility. The HENMT1 gene is a key player in piRNAs
Zeina Wehbe, Anne‐Laure Barbotin, Angèle Boursier, Caroline Cazin, Jean‐Pascal Hograindleur, Marie Bidart, Emeline Fontaine, Pauline Plouvier, Florence Puch, Véronique Satre, Christophe Arnoult, Selima Fourati Ben Mustapha, Raoudha Zouari, Nicolas Thierry‑Mieg, Pierre F. Ray, Zine‑Eddine Kherraf, Charles Coutton, Guillaume Martinez   +17 more
wiley   +1 more source

Testis-specific lncRNA Teshl regulates acrosome biogenesis to maintain sperm structure and function

Cell & Bioscience
Background The testis exhibits the highest tissue-specific gene expression of all organs, including both coding and non-coding genes. Our previous study reported that Teshl, a testis-specific long noncoding RNA, associates with heat shock factor 2 (HSF2),
Seung Pyo Hong, Seong Hyeon Hong, Gwidong Han, Seung Jae Lee, Youngsoo Oh, Chunghee Cho   +5 more
doaj   +1 more source

Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies

Andrology, Volume 13, Issue 5, Page 1044-1064, July 2025.
Abstract Background In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle, which contains dynein motor proteins that provide the mechanical force for sperm propulsion and ...
Emma Cavarocchi, Maëva Drouault, Joao C. Ribeiro, Violaine Simon, Marjorie Whitfield, Aminata Touré   +5 more
wiley   +1 more source