Results 31 to 40 of about 3,330 (184)

Myosin Va participates in acrosomal formation and nuclear morphogenesis during spermatogenesis of Chinese mitten crab Eriocheir sinensis. [PDF]

PLoS ONE, 2010
BACKGROUND: The Chinese mitten crab Eriocheir sinensis belongs to the Class Crustacea, Decapoda, Brachyura. The spermatozoon of this species is of aflagellated type, it has a spherical acrosome surrounded by the cup-shaped nucleus, which are unique to ...
Xiao Sun, Ying He, Lin Hou, Wan-Xi Yang, Wan-Xi Yang   +4 more
doaj   +1 more source

Human sperm ion channel (dys)function:implications for fertilization [PDF]

, 2019
BACKGROUND: Intensive research on sperm ion channels has identified members of several ion channel families in both mouse and human sperm. Gene knock-out studies have unequivocally demonstrated the importance of the calcium and potassium conductances in ...
Barratt, Christopher L. R., Brown, Sean G., Martins da Silva, Sarah J., Publicover, Stephen J.   +3 more
core   +4 more sources

A decrease of docosahexaenoic acid in testes of mice fed a high-fat diet is associated with impaired sperm acrosome reaction and fertility

Asian Journal of Andrology, 2021
Obesity is a major worldwide health problem that is related to most chronic diseases, including male infertility. Owing to its wide impact on health, mechanisms underlying obesity-related infertility remain unknown. In this study, we report that mice fed
Julio Bunay, Luz-Maria Gallardo, Jorge Luis Torres-Fuentes, M Verónica Aguirre-Arias, Renan Orellana, Néstor Sepúlveda, Ricardo D Moreno   +6 more
doaj   +1 more source

Novel testis-expressed profilin IV associated with acrosome biogenesis and spermatid elongation [PDF]

MHR: Basic science of reproductive medicine, 2005
A novel profilin, named profilin IV, was cloned and characterized as a testicular isoform, distinct from the previously described testis-specific profilin III. Profilin IV showed only 30% amino acid identity with the other mammalian profilins; nevertheless, database searches produced significant alignments with the conserved profilin domain.
Heike, Obermann, Inka, Raabe, Marga, Balvers, Bärbel, Brunswig, Wolfgang, Schulze, Christiane, Kirchhoff   +5 more
openaire   +2 more sources

Essential role of CFTR in PKA-dependent phosphorylation, alkalinization, and hyperpolarization during human dperm capacitation [PDF]

, 2017
Mammalian sperm require to spend a limited period of time in the female reproductive tract to become competent to fertilize in a process called capacitation.
Austin, Berger, Bobadilla, Buffone, Buffone, Buffone, Buffone, Chang, Chen, Chen, Chen, Chávez, Chávez, De Jonge, De La Vega-Beltran, Demarco, Diao, Dirami, Dostmann, Ellsworth, Escoffier, Esteves, Figueiras-Fierro, Gabriel, Gadsby, Hernández-González, Ishiguro, José, Kase, Kujala, Köhn, l'Hoste, Laemmli, Leclerc, Li, Lishko, Lochner, Luconi, López-González, Ma, Melis, Mortimer, Muanprasat, Navarrete, Neill, Nishigaki, Nolan, Okamura, Rode, Schulz, Sheppard, Sorum, Stival, Stival, Tabcharani, Tang, Towbin, Visconti, Visconti, Wennemuth, Wertheimer, Xu, Zeng, Zeng   +63 more
core   +1 more source

Loss of ACTL7A causes small head sperm by defective acrosome-acroplaxome-manchette complex

Reproductive Biology and Endocrinology, 2023
Background Actin-like 7 A (ACTL7A) is essential for acrosome formation, fertilization and early embryo development. ACTL7A variants cause acrosome detachment responsible for male infertility and early embryonic arrest.
Yini Zhang, Jianan Tang, Xuemei Wang, Yisi Sun, Tianying Yang, Xiaorong Shen, Xinyue Yang, Huijuan Shi, Xiaoxi Sun, Aijie Xin   +9 more
doaj   +1 more source

Mfsd14a disruption causes globozoospermia [PDF]

, 2016
The Mfsd14a gene, previously called Hiat1, encodes a transmembrane protein of unknown function with homology to the solute carrier protein family. To study the function of the MFSD14A protein, mutant mice (Mus musculus, strain 129S6Sv/Ev) were generated ...
Colledge, William Henry, Doran, Joanne, Hammett-Burke, Rebecca, Kyle, Victoria, Walters, Cara, Wooding, Peter   +5 more
core   +2 more sources

cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor

Frontiers in Endocrinology, 2022
Cyclic adenosine monophosphate/Protein kinase A (cAMP/PKA) signaling pathway is the master regulator of endocrine tissue function. The level, compartmentalization and amplitude of cAMP response are finely regulated by phosphodiesterases (PDEs).
Federica Campolo, Chiara Capponi, Maria Grazia Tarsitano, Maria Grazia Tarsitano, Marta Tenuta, Carlotta Pozza, Daniele Gianfrilli, Fabio Magliocca, Mary A. Venneri, Elena Vicini, Andrea Lenzi, Andrea M. Isidori, Federica Barbagallo, Federica Barbagallo   +13 more
doaj   +1 more source

Why are Functional Amyloids Non-Toxic in Humans? [PDF]

, 2017
Amyloids were first identified in association with amyloidoses, human diseases in which proteins and peptides misfold into amyloid fibrils. Subsequent studies have identified an array of functional amyloid fibrils that perform physiological roles in ...
Hewitt, EW, Jackson, MP
core   +2 more sources

A mouse protein that localizes to acrosome and sperm tail is regulated by Y-chromosome [PDF]

, 2013
BACKGROUND: Acrosomal proteins play crucial roles in the physiology of fertilization. Identification of proteins localizing to the acrosome is fundamental to the understanding of its contribution to fertilization.
Manju S Devi, Rachel A Jesudasan, Rupa Bhattacharya, Vishnu M Dhople   +3 more
core   +1 more source