Loss of Zona Pellucida Binding Proteins in the Acrosomal Matrix Disrupts Acrosome Biogenesis and Sperm Morphogenesis [PDF]
Molecular and Cellular Biology, 2007 Zona pellucida binding protein 1 (ZPBP1), a spermatid and spermatozoon protein that localizes to the acrosome, was originally identified in pigs and named for its binding to the oocyte zona pellucida. In an in silico search for germ cell-specific genes, Zpbp1 and its novel paralog, Zpbp2, were discovered and confirmed to be expressed only in the testes
Yi-Nan, Lin +4 more
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An Overview of The Globozoospermia as A Multigenic Identified Syndrome [PDF]
International Journal of Fertility and Sterility, 2019 Acrosome plays an integral role during fertilization and its absence in individuals with globozoospermia leads to failure of in vitro fertilization (IVF) and oocyte activation post-intracytoplasmic sperm injection (ICSI).
Parastoo Modarres +2 more
doaj +1 more source
Myosin Va participates in acrosomal formation and nuclear morphogenesis during spermatogenesis of Chinese mitten crab Eriocheir sinensis. [PDF]
PLoS ONE, 2010 BACKGROUND: The Chinese mitten crab Eriocheir sinensis belongs to the Class Crustacea, Decapoda, Brachyura. The spermatozoon of this species is of aflagellated type, it has a spherical acrosome surrounded by the cup-shaped nucleus, which are unique to ...
Xiao Sun +4 more
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Asian Journal of Andrology, 2021 Obesity is a major worldwide health problem that is related to most chronic diseases, including male infertility. Owing to its wide impact on health, mechanisms underlying obesity-related infertility remain unknown. In this study, we report that mice fed
Julio Bunay +6 more
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Loss of ACTL7A causes small head sperm by defective acrosome-acroplaxome-manchette complex
Reproductive Biology and Endocrinology, 2023 Background Actin-like 7 A (ACTL7A) is essential for acrosome formation, fertilization and early embryo development. ACTL7A variants cause acrosome detachment responsible for male infertility and early embryonic arrest.
Yini Zhang +9 more
doaj +1 more source
Frontiers in Endocrinology, 2022 Cyclic adenosine monophosphate/Protein kinase A (cAMP/PKA) signaling pathway is the master regulator of endocrine tissue function. The level, compartmentalization and amplitude of cAMP response are finely regulated by phosphodiesterases (PDEs).
Federica Campolo +13 more
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Sirt1 regulates acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice [PDF]
Development, 2017 ABSTRACT Sirt1 is a member of the sirtuin family of proteins and has important roles in numerous biological processes. Sirt1−/− mice display an increased frequency of abnormal spermatozoa, but the mechanism of Sirt1 in spermiogenesis remains largely unknown.
Chao Liu +14 more
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Novel testis-expressed profilin IV associated with acrosome biogenesis and spermatid elongation [PDF]
MHR: Basic science of reproductive medicine, 2005 A novel profilin, named profilin IV, was cloned and characterized as a testicular isoform, distinct from the previously described testis-specific profilin III. Profilin IV showed only 30% amino acid identity with the other mammalian profilins; nevertheless, database searches produced significant alignments with the conserved profilin domain.
Heike, Obermann +5 more
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Condensed Mitochondria Assemble Into the Acrosomal Matrix During Spermiogenesis
Frontiers in Cell and Developmental Biology, 2022 Mammalian spermatogenesis is associated with the transient appearance of condensed mitochondria, a singularity of germ cells with unknown function.
Mindong Ren +11 more
doaj +1 more source
Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse. [PDF]
PLoS ONE, 2013 PRAME belongs to a group of cancer/testis antigens (CTAs) that are characterized by their restricted expression in normal gametogenic tissues and a variety of tumors.
Bhavesh V Mistry +7 more
doaj +1 more source