Results 11 to 20 of about 3,330 (184)

Stage‐Resolved Phosphoproteomic Landscape of Mouse Spermiogenesis Reveals Key Kinase Signaling in Sperm Morphogenesis [PDF]

Advanced Science
Spermiogenesis is the committed step of sperm production, during which spermatid cells undergo dramatic morphological transformations and transcriptional silencing.
Tianyu Zhu, Yan Zhu, Xinyi Jiang, Xiangzheng Zhang, Bing Wang, Yu Chen, Yichen Zhao, Yulian Wang, Qi Zhou, Zhongyan Han, Yaling Qi, Mengjiao Luo, Haixia Tu, Bingjie Hao, Mengmeng Gao, Jie Ren, Xin Zhou, Xingyu Zhang, Xu Chen, Haojie Li, Qian Huang, Chenghao Situ, Yueshuai Guo, Hui Zhu, Yan Li, Xuejiang Guo   +25 more
doaj   +3 more sources

Atg7 is required for acrosome biogenesis during spermatogenesis in mice [PDF]

Cell Research, 2014
The acrosome is a specialized organelle that covers the anterior part of the sperm nucleus and plays an essential role in the process of fertilization. The molecular mechanism underlying the biogenesis of this lysosome-related organelle (LRO) is still largely unknown.
Yaqing Wang, Haifeng Wan, Qi Chen
exaly   +5 more sources

FAM209 associates with DPY19L2, and is required for sperm acrosome biogenesis and fertility in mice [PDF]

Journal of Cell Science, 2021
ABSTRACT Infertility afflicts up to 15% of couples globally each year with men a contributing factor in 50% of these cases. Globozoospermia is a rare condition found in infertile men, which is characterized by defective acrosome biogenesis leading to the production of round-headed sperm.
Julio M Castaneda, Keisuke Shimada, Yuhkoh Satouh   +2 more
exaly   +4 more sources

ELAPOR1 is a copper-dependent tethering factor driving proacrosomal vesicle fusion during acrosome biogenesis [PDF]

Proceedings of the National Academy of Sciences of the United States of America
The acrosome is a crucial organelle essential for sperm function and male fertility. During acrosome biogenesis, numerous proacrosomal vesicles (PAVs) are transported to the concave region of the nuclear membrane and fuse to form the acrosome.
Jiahao Ma, Xinshui Tan, Sanduo Zheng
exaly   +4 more sources

Repression of autophagy leads to acrosome biogenesis disruption caused by a sub-chronic oral administration of polystyrene nanoparticles

Environment International, 2022
As a new widespread contaminant, nanoplastics (NPs) pose a potential risk to human health. Nevertheless, the adverse effects of NPs on the male reproductive system are poorly understood.
Lixiao Zhou, Shu-Qun Cheng, Jieying Gao
exaly   +3 more sources

Protein disulfide isomerase A6 (PDIA6) is essential for acrosome biogenesis and male fertility in mice [PDF]

Cell Communication and Signaling
Background The family of protein disulfide isomerases (PDIs) are thiol oxidoreductases located predominantly in the endoplasmic reticulum that catalyze thiol-disulfide exchange for normal protein folding.
Xiaofeng Yan, Yaqiong Zhang, Aizhen Yang, Yufeng Hou, Raymond B. Birge, Jinxing Lv, Yi Wu   +6 more
doaj   +2 more sources

PFN4 is required for manchette development and acrosome biogenesis during mouse spermiogenesis.

Development, 2022
ABSTRACT Profilin 4 (Pfn4) is expressed during spermiogenesis and localizes to the acrosome-acroplaxome-manchette complex. Here, we generated PFN4-deficient mice, with sperm displaying severe impairment in manchette formation. Interestingly, HOOK1 staining suggests that the perinuclear ring is established; however, ARL3 staining is ...
Umer N, Phadke S, Shakeri F, Arévalo L, Lohanadan K, Kirfel G, Sylvester M, Buness A, Schorle H.   +8 more
europepmc   +3 more sources

Acrosome biogenesis: Revisiting old questions to yield new insights. [PDF]

Spermatogenesis, 2011
The acrosome is a unique membranous organelle located over the anterior part of the sperm nucleus that is highly conserved throughout evolution. This acidic vacuole contains a number of hydrolytic enzymes that, when secreted, help the sperm penetrate the egg's coats.
Berruti G, Paiardi C.
europepmc   +4 more sources

AU040320 deficiency leads to disruption of acrosome biogenesis and infertility in homozygous mutant mice. [PDF]

Sci Rep, 2018
AbstractStudy of knockout (KO) mice has helped understand the link between many genes/proteins and human diseases. Identification of infertile KO mice provides valuable tools to characterize the molecular mechanisms underlying gamete formation. The KIAA0319L gene has been described to have a putative association with dyslexia; surprisingly, we observed
Guidi LG, Holloway ZG, Arnoult C, Ray PF, Monaco AP, Molnár Z, Velayos-Baeza A.   +6 more
europepmc   +5 more sources

Vps13b is required for acrosome biogenesis through functions in Golgi dynamic and membrane trafficking. [PDF]

Cell Mol Life Sci, 2020
The sperm acrosome is a lysosome-related organelle that develops using membrane trafficking from the Golgi apparatus as well as the endolysosomal compartment. How vesicular trafficking is regulated in spermatids to form the acrosome remains to be elucidated. VPS13B, a RAB6-interactor, was recently shown involved in endomembrane trafficking.
Da Costa R, Bordessoules M, Guilleman M, Carmignac V, Lhussiez V, Courot H, Bataille A, Chlémaire A, Bruno C, Fauque P, Thauvin C, Faivre L, Duplomb L.   +12 more
europepmc   +3 more sources