Results 11 to 20 of about 1,969 (137)

Differential Expression and Localization of EHBP1L1 during the First Wave of Rat Spermatogenesis Suggest Its Involvement in Acrosome Biogenesis [PDF]

Biomedicines, 2022
The identification and characterization of new proteins involved in spermatogenesis is fundamental, considering that good-quality gametes are basic in ensuring proper reproduction.
Massimo Venditti, Sérgio Minucci, Venditti Massimo   +2 more
exaly   +4 more sources

ELAPOR1 mediated vesicle traffic is required for acrosome biogenesis and male fertility in mice [PDF]

Cellular and Molecular Life Sciences
Spermiogenesis is the post-meiotic differentiation and morphological change of the haploid spermatids. Acrosome biogenesis is one of the key events of spermiogenesis, which generates a specialized membranous organelle crucial for shaping the balanced ...
Runze Ding, Qinghua Guo, Li Wang, Ningyuan Tang, Xiao Fang, Zhixiang Xin, Wenzhen Zhao, Yue Liu   +7 more
doaj   +4 more sources

Protein disulfide isomerase A6 (PDIA6) is essential for acrosome biogenesis and male fertility in mice [PDF]

Cell Communication and Signaling
Background The family of protein disulfide isomerases (PDIs) are thiol oxidoreductases located predominantly in the endoplasmic reticulum that catalyze thiol-disulfide exchange for normal protein folding.
Xiaofeng Yan, Yaqiong Zhang, Aizhen Yang, Yufeng Hou, Raymond B. Birge, Jinxing Lv, Yi Wu   +6 more
doaj   +4 more sources

Stage‐Resolved Phosphoproteomic Landscape of Mouse Spermiogenesis Reveals Key Kinase Signaling in Sperm Morphogenesis [PDF]

Advanced Science
Spermiogenesis is the committed step of sperm production, during which spermatid cells undergo dramatic morphological transformations and transcriptional silencing.
Tianyu Zhu, Yan Zhu, Xinyi Jiang, Xiangzheng Zhang, Bing Wang, Yu Chen, Yichen Zhao, Yulian Wang, Qi Zhou, Zhongyan Han, Yaling Qi, Mengjiao Luo, Haixia Tu, Bingjie Hao, Mengmeng Gao, Jie Ren, Xin Zhou, Xingyu Zhang, Xu Chen, Haojie Li, Qian Huang, Chenghao Situ, Yueshuai Guo, Hui Zhu, Yan Li, Xuejiang Guo   +25 more
doaj   +3 more sources

ELAPOR1 is a copper-dependent tethering factor driving proacrosomal vesicle fusion during acrosome biogenesis [PDF]

Proceedings of the National Academy of Sciences of the United States of America
The acrosome is a crucial organelle essential for sperm function and male fertility. During acrosome biogenesis, numerous proacrosomal vesicles (PAVs) are transported to the concave region of the nuclear membrane and fuse to form the acrosome.
Kexin Zhang, Sanduo Zheng, Fengchao Wang   +2 more
exaly   +5 more sources

PFN4 is required for manchette development and acrosome biogenesis during mouse spermiogenesis.

Development, 2022
ABSTRACT Profilin 4 (Pfn4) is expressed during spermiogenesis and localizes to the acrosome-acroplaxome-manchette complex. Here, we generated PFN4-deficient mice, with sperm displaying severe impairment in manchette formation. Interestingly, HOOK1 staining suggests that the perinuclear ring is established; however, ARL3 staining is ...
Umer N, Phadke S, Shakeri F, Arévalo L, Lohanadan K, Kirfel G, Sylvester M, Buness A, Schorle H.   +8 more
europepmc   +3 more sources

Repression of autophagy leads to acrosome biogenesis disruption caused by a sub-chronic oral administration of polystyrene nanoparticles

Environment International, 2022
As a new widespread contaminant, nanoplastics (NPs) pose a potential risk to human health. Nevertheless, the adverse effects of NPs on the male reproductive system are poorly understood.
Yinyin Xia, Shuqun Cheng, Jieying Gao
exaly   +3 more sources

Acrosome biogenesis: Revisiting old questions to yield new insights. [PDF]

Spermatogenesis, 2011
The acrosome is a unique membranous organelle located over the anterior part of the sperm nucleus that is highly conserved throughout evolution. This acidic vacuole contains a number of hydrolytic enzymes that, when secreted, help the sperm penetrate the egg's coats.
Berruti G, Paiardi C.
europepmc   +4 more sources

CFAP65 is required in the acrosome biogenesis and mitochondrial sheath assembly during spermiogenesis

Human Molecular Genetics, 2021
Abstract Asthenoteratospermia is a common cause of male infertility. Recent studies have revealed that CFAP65 mutations lead to severe asthenoteratospermia due to acrosome hypoplasia and flagellum malformations. However, the molecular mechanism underlying CFAP65-associated sperm malformation is largely unclear.
Hongchuan Nie, Chaofeng Tu, Lanlan Meng   +2 more
exaly   +3 more sources

Vps13b is required for acrosome biogenesis through functions in Golgi dynamic and membrane trafficking. [PDF]

Cell Mol Life Sci, 2020
The sperm acrosome is a lysosome-related organelle that develops using membrane trafficking from the Golgi apparatus as well as the endolysosomal compartment. How vesicular trafficking is regulated in spermatids to form the acrosome remains to be elucidated. VPS13B, a RAB6-interactor, was recently shown involved in endomembrane trafficking.
Da Costa R, Bordessoules M, Guilleman M, Carmignac V, Lhussiez V, Courot H, Bataille A, Chlémaire A, Bruno C, Fauque P, Thauvin C, Faivre L, Duplomb L.   +12 more
europepmc   +3 more sources