Results 61 to 70 of about 1,658 (163)

Essential role for SUN5 in anchoring sperm head to the tail

eLife, 2017
SUN (Sad1 and UNC84 domain containing)-domain proteins are reported to reside on the nuclear membrane playing distinct roles in nuclear dynamics. SUN5 is a new member of the SUN family, with little knowledge regarding its function.
Yongliang Shang, Fuxi Zhu, Lina Wang, Ying-Chun Ouyang, Ming-Zhe Dong, Chao Liu, Haichao Zhao, Xiuhong Cui, Dongyuan Ma, Zhiguo Zhang, Xiaoyu Yang, Yueshuai Guo, Feng Liu, Li Yuan, Fei Gao, Xuejiang Guo, Qing-Yuan Sun, Yunxia Cao, Wei Li   +18 more
doaj   +1 more source

The LINC complex component Sun4 plays a crucial role in sperm head formation and fertility

Biology Open, 2015
LINC complexes are evolutionarily conserved nuclear envelope bridges, physically connecting the nucleus to the peripheral cytoskeleton. They are pivotal for dynamic cellular and developmental processes, like nuclear migration, anchoring and positioning ...
Elisabeth Pasch, Jana Link, Carolin Beck, Stefanie Scheuerle, Manfred Alsheimer   +4 more
doaj   +1 more source

Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies

Andrology, Volume 13, Issue 5, Page 1044-1064, July 2025.
Abstract Background In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle, which contains dynein motor proteins that provide the mechanical force for sperm propulsion and ...
Emma Cavarocchi, Maëva Drouault, Joao C. Ribeiro, Violaine Simon, Marjorie Whitfield, Aminata Touré   +5 more
wiley   +1 more source

Globozoospermia and lack of acrosome formation in GM130-deficient mice [PDF]

Cell Death & Disease, 2017
AbstractGlobozoospermia is a common reproductive disorder that causes male infertility in humans, and the malformation or loss of acrosomes is the prominent feature of this disease. Although the acrosome is thought to be derived from the Golgi apparatus, the detailed molecular mechanisms remain unclear.
Han, Feng, Liu, Chunyi, Zhang, Lianjun, Chen, Min, Zhou, Yang, Qin, Yan, Wang, Yaqing, Chen, Min, Duo, Shuguang, Cui, Xiuhong, Bao, Shilai, Gao, Fei   +11 more
openaire   +2 more sources

Novel variations in TENT5D lead to teratozoospermia in infertile patients

Andrology, Volume 12, Issue 6, Page 1336-1346, September 2024.
Abstract Purpose Teratozoospermia is the main pathogenic factor of male infertility. However, the genetic etiology of teratozoospermia is largely unknown. This study aims to clarify the relationship between novel variations in TENT5D and teratozoospermia in infertile patients. Materials and methods Two infertile patients were enrolled.
Ying‐Teng Zhang, Gan Shen, Liang‐Chai Zhuo, Xue Yang, Su‐Yan Wang, Tie‐Chao Ruan, Chuan Jiang, Xiang Wang, Yan Wang, Yi‐Hong Yang, Ying Shen   +10 more
wiley   +1 more source

Sperm morphology: Evaluating its clinical relevance in contemporary fertility practice

Reproductive Medicine and Biology, Volume 23, Issue 1, January/December 2024.
Abstract Background The World Health Organization (WHO) recommends reporting sperm morphology in a standard semen analysis. However, the clinical utility and prognostic value of morphology is often debated. Methods We reviewed and summarized studies that assessed both the benefits and limitations of sperm morphology in the context of natural fertility,
Daniel L. Pelzman, Jay I. Sandlow
wiley   +1 more source

Homozygous deletion of the DPY19L2 gene as a major genetic cause of globozoospermia: a case report from Senegal

Egyptian Journal of Medical Human Genetics
Background Globozoospermia is a rare but serious teratozoospermia, characterised by ejaculates consisting of entirely of round-headed spermatozoa without acrosomes or, in the case of partial globozoospermia, containing a variable proportion (20 to 90 ...
Thierno Abdoulaye Diallo, Abdou Diop, Boubacar Faye, Babacar Ndiaye, Mama Sy, Libasse Niang, Micheline Misrahi, Rena Derwiche, Chantal Mahou, Natacha Gaitch, Brigitte Martinez, Florence Hourriez, Thierry Bienvenu, Abdoulaye Seck   +13 more
doaj   +1 more source

Deleterious genetic changes in AGTPBP1 result in teratozoospermia with sperm head and flagella defects

Journal of Cellular and Molecular Medicine, Volume 28, Issue 2, January 2024.
Abstract Approximately 10%–15% of couples worldwide are infertile, and male factors account for approximately half of these cases. Teratozoospermia is a major cause of male infertility. Although various mutations have been identified in teratozoospermia, these can vary among ethnic groups.
Yu‐Hua Lin, Ya‐Yun Wang, Tsung‐Hsuan Lai, Jih‐Lung Teng, Chi‐Wei Lin, Chih‐Chun Ke, I‐Shing Yu, Hui‐Ling Lee, Chying‐Chyuan Chan, Chi‐Hua Tung, Donald F. Conrad, Moira K. O'Bryan, Ying‐Hung Lin   +12 more
wiley   +1 more source

Implementation of World Health Organization Recommendations for Semen Analysis: A Survey of Laboratories in the United Kingdom

Andrologia, Volume 2024, Issue 1, 2024.
The standard method for identification of male fertility status is a semen analysis. This is performed in fertility and pathology laboratories accredited by different bodies in the UK such as the HFEA or UKAS, and is based on whether they perform licenced clinical treatment or diagnostic testing.
Lisa M Bosman, Iulia A Grosu, Peter J Ellis, Darren K Griffin, Sheryl T Homa, Marta Olszewska   +5 more
wiley   +1 more source

Study of Sperm Chromatin in Infertile Men with Globozoospermia: A Systematic Review Article

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2019
Background and Aim: Globozoospermia is a severe sperm morphological abnormality in men that characterized by round-headed spermatozoa with low or absence acrosome structure in their sperm samples.
Marziyeh Tavalaee , Nasim Eskandari , Mohammad Hossein Nasr-Esfahani   +2 more
doaj