Results 41 to 50 of about 1,658 (163)

A newly discovered mutation in PICK1 in a human with globozoospermia [PDF]

Asian Journal of Andrology, 2010
Globozoospermia is a human infertility syndrome caused by spermatogenesis defects (OMIM 102530). Acrosome plays an important role at the site of sperm-zonapellucida binding during the fertilization process. Thus, malformation of the acrosome is the most prominent feature seen in globozoospermia.
Gang, Liu, Qiu-Wen, Shi, Guang-Xiu, Lu
openaire   +2 more sources

A novel loss-of-function variant in PNLDC1 inducing oligo-astheno-teratozoospermia and male infertility

Asian Journal of Andrology, 2023
Male infertility is a major reproductive disorder, which is clinically characterized by highly heterogeneous phenotypes of abnormal sperm count or quality.
Si-Yi Zhao, Lan-Lan Meng, Zhao-Li Du, Yue-Qiu Tan, Wen-Bin He, Xiong Wang   +5 more
doaj   +1 more source

Chromosome aneuploidy in the spermatozoa of two men with globozoospermia [PDF]

MHR: Basic science of reproductive medicine, 2004
The objective of this study was to determine the aneuploidy level in spermatozoa in two men with globozoospermia. Sperm nuclei were analysed by fluorescence in-situ hybridization (FISH) in two infertile males with globozoospermia. Dual FISH for chromosomes 7 and 9, 13 and 21, and triple FISH for chromosomes X, Y, and 18 was performed.
F, Morel, N, Douet-Guilbert, A, Moerman, B, Duban, C, Marchetti, B, Delobel, M-J, Le Bris, V, Amice, M, De Braekeleer   +8 more
openaire   +2 more sources

Globozoospermia

Kathmandu University Medical Journal
Male infertility may be due to low sperm concentration, poor sperm motility, or abnormal morphology. Among the factors involved in male infertility, there is a rare morphology disorder called “Globozoospermia”. This condition is primarily characterized by the presence of round‐headed spermatozoa, absence of acrosomal cap and cytoskeleton defects around
L, Bhattarai, B, Gautam, B B, Raut, S, Chettri   +3 more
openaire   +2 more sources

From azoospermia to macrozoospermia, a phenotypic continuum due to mutations in the ZMYND15 gene

Asian Journal of Andrology, 2022
Thanks to tremendous advances in sequencing technologies and in particular to whole exome sequencing (WES), many genes have now been linked to severe sperm defects.
Zine-Eddine Kherraf, Caroline Cazin, Florence Lestrade, Jana Muronova, Charles Coutton, Christophe Arnoult, Nicolas Thierry-Mieg, Pierre F Ray   +7 more
doaj   +1 more source

Successful pregnancies and a live birth after intracytoplasmic sperm injection in globozoospermia

Journal of Human Reproductive Sciences, 2009
Globozoospermia is a severe form of teratozoospermia characterized by round-headed acrosomeless spermatozoa. Here we present two successful pregnancies and a live birth after intracytoplasmic sperm injection.
Manish R Banker, Pravin M Patel, Bharat V Joshi, Preeti B Shah, Rakhi Goyal   +4 more
doaj   +1 more source

Mechanism of Acrosome Biogenesis in Mammals

Frontiers in Cell and Developmental Biology, 2019
During sexual reproduction, two haploid gametes fuse to form the zygote, and the acrosome is essential to this fusion process (fertilization) in animals.
Muhammad Babar Khawar, Muhammad Babar Khawar, Hui Gao, Wei Li, Wei Li   +4 more
doaj   +1 more source

Endoplasmic Reticulum-Localized Transmembrane Protein Dpy19L1 Is Required for Neurite Outgrowth. [PDF]

PLoS ONE, 2016
The endoplasmic reticulum (ER), including the nuclear envelope, is a continuous and intricate membrane-bound organelle responsible for various cellular functions. In neurons, the ER network is found in cell bodies, axons, and dendrites.
Keisuke Watanabe, Norihisa Bizen, Noboru Sato, Hirohide Takebayashi   +3 more
doaj   +1 more source

Improving ARTs: Microfluidics as a Tool for Sperm Selection

Andrology, EarlyView.
ABSTRACT Sperm selection is a critical step in assisted reproductive technology (ART), as sperm quality directly influences embryo quality. In vivo, the female reproductive tract imposes several physical and physiological barriers that favors only the most optimal spermatozoa reaching the fertilization site.
A. Pérez‐Gómez, A. Urriés, J. L. de Pablo, L. Serrano‐Ramón, S. Sanchez, R. Herrer, J. M. Morrell, C. Malo   +7 more
wiley   +1 more source

Whole exome sequencing identifies a new DPY19L2 variant c.1232_1233insA in Tunisian infertile patient with globozoospermia

Middle East Fertility Society Journal
Background Globozoospermia is a rare male infertility disorder characterized by the presence in the ejaculate of round-headed sperm cells lacking an acrosome, a crucial structure for fertilization.
Wiem Ayed, Nicolas Thierry-Mieg, Wajh Hammami, Meriem Ben Khalifa, Sonia Mnallah, Hanène Eloumi, Amel Zhioua, Anis Chaker, Fethi Zhioua, Pierre F. Ray, Ahlem Amouri   +10 more
doaj   +1 more source