Results 51 to 60 of about 1,658 (163)

Toward Development of the Male Pill: A Decade of Potential Non-hormonal Contraceptive Targets

Frontiers in Cell and Developmental Biology, 2020
With the continued steep rise of the global human population, and the paucity of safe and practical contraceptive options available to men, the need for development of effective and reversible non-hormonal methods of male fertility control is widely ...
Katarzyna Kent, Katarzyna Kent, Katarzyna Kent, Madelaine Johnston, Madelaine Johnston, Natasha Strump, Natasha Strump, Thomas X. Garcia, Thomas X. Garcia, Thomas X. Garcia   +9 more
doaj   +1 more source

Assisted reproductive treatments with hyperbaric oxygen therapy in male infertility

Urology Research and Practice, 2021
Objective: This study aimed to analyze the results of hyperbaric oxygen therapy (HBOT) in addition to assisted reproductive technologies in male infertility cases. Material and methods: Medical records of male infertility patients who had HBOT sessions
Kübra Özgök Kangal, Yaşar Özgök
doaj   +1 more source

Mutations of the aurora kinase C gene causing macrozoospermia are the most frequent genetic cause of male infertility in Algerian men

Asian Journal of Andrology, 2015
Klinefelter syndrome and Y-chromosomal microdeletion analyses were once the only two genetic tests offered to infertile men. Analyses of aurora kinase C (AURKC) and DPY19L2 are now recommended for patients presenting macrozoospermia and globozoospermia ...
Leyla Ounis, Abdelali Zoghmar, Charles Coutton, Leila Rouabah, Maroua Hachemi, Delphine Martinez, Guillaume Martinez, Ines Bellil, Douadi Khelifi, Christophe Arnoult, Julien Fauré, Sebti Benbouhedja, Abdelkader Rouabah, Pierre F Ray   +13 more
doaj   +1 more source

Mapping the Non‐Canonical Splicing Variants: Decrypting the Hidden Genetic Architecture of Idiopathic Male Infertility

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study highlights the significance of non‐canonical splicing variants in male infertility, a factor often overlooked during the analysis of high‐throughput sequencing data. Incorporating the non‐canonical splicing variants prioritization in the genetic analysis pipeline will increase the genetic diagnosis of patients with male infertility ...
Kuokuo Li, Yuge Chen, Dongdong Tang, Yuying Sheng, Xu Han, Hao Geng, Na Zhang, Zongliu Duan, Guanxiong Wang, Yang Gao, Rui Guo, Rong Hua, Zhiming Ding, Chuan Xu, Qunshan Shen, Zhen Yu, Bing Song, Mingrong Lv, Yuping Xu, Huan Wu, Ji Wu, Yunxia Cao, Xiaojin He   +22 more
wiley   +1 more source

Will whole-genome sequencing become the first-line genetic analysis for male infertility in the near future?

Basic and Clinical Andrology, 2021
Résumé Alors que la stratégie actuelle d'analyse de génétique moléculaire de l'infertilité masculine est basée sur une approche dite "gène candidat", le développement des technologies de séquençage de nouvelle génération, comme le séquençage complet de l'
Farah Ghieh, Anne-Laure Barbotin, Clara Leroy, François Marcelli, Nelly Swierkowsky-Blanchard, Valérie Serazin, Béatrice Mandon-Pepin, François Vialard   +7 more
doaj   +1 more source

Identification of a DPY19L2 Mutation Linking Globozoospermia to Congenital Heart Defects in a Consanguineous Family: A Genetic Analysis

Andrologia, Volume 2026, Issue 1, 2026.
Background Male infertility is a complex condition with significant genetic heterogeneity. Globozoospermia, a rare form of teratozoospermia characterized by round‐headed sperm, is frequently associated with mutations in the DPY19L2 gene. While the link between DPY19L2 and infertility is established, the co‐occurrence of male infertility and congenital ...
Hongjing Li, Jun He, Chaojun Chen, Zongjian Tan, Weiming Chen, Maobo Tian, Harleen Khatra   +6 more
wiley   +1 more source

Reduction of truncated Kit Expression in Men with Abnormal Semen Parameters, Globozoospermia and History of Low or Fertilization Failure

Cell Journal, 2019
Objective: Phospholipase C zeta 1 (PLCζ) is one of the main sperm factor involved in oocyte activation and other factors may assist this factor to induce successful fertilization. Microinjection of recombinant tr-kit, a truncated form of c-kit receptor,
Somayeh Haghighat, Marziyeh Tavalaee, Zahra Zakeri, Mahdi Noureddini, Abdolhossein Shahverdi, Mohammad Hossein Nasr Esfahani   +5 more
doaj   +1 more source

Fine characterisation of a recombination hotspot at the DPY19L2 locus and resolution of the paradoxical excess of duplications over deletions in the general population. [PDF]

PLoS Genetics, 2013
We demonstrated previously that 75% of infertile men with round, acrosomeless spermatozoa (globozoospermia) had a homozygous 200-Kb deletion removing the totality of DPY19L2.
Charles Coutton, Farid Abada, Thomas Karaouzene, Damien Sanlaville, Véronique Satre, Joël Lunardi, Pierre-Simon Jouk, Christophe Arnoult, Nicolas Thierry-Mieg, Pierre F Ray   +9 more
doaj   +1 more source

EP300‐interacting inhibitor of differentiation 3 is required for spermatogenesis in mice

Andrology, Volume 13, Issue 7, Page 1901-1912, October 2025.
Abstract Background Mammalian spermatogenesis is a highly complex process of cell proliferation, meiosis, and differentiation. A series of genes are expressed in an orderly and precise manner to ensure spermatogenesis, with chromatin undergoing intricate changes throughout.
Ping Zhang, Longsheng Zhang, Li Yu, Xinli Zhou, Xu Chen, Yuchuan Zhou, Ningling Wang, Hui Zhu   +7 more
wiley   +1 more source

Novel ACTL7A variants in males lead to fertilization failure and male infertility

Andrology, Volume 13, Issue 5, Page 1117-1126, July 2025.
Abstract Background Total fertilization failure occurs in 1%–3% of all intracytoplasmic sperm injection cycles. Genetic defects are found to be crucial causes responsible for total fertilization failure after intracytoplasmic sperm injection. However, the reported genes only elucidate a small proportion of total fertilization failure cases, and more ...
Meng Wang, Juepu Zhou, Rui Long, Huizi Jin, Limin Gao, Lixia Zhu, Lei Jin   +6 more
wiley   +1 more source