Results 51 to 60 of about 2,192 (198)

Assisted Oocyte Activation following Intracytoplasmic Sperm Injection: A Sensible Option for Infertile Couples with Severe Teratozoospermia [PDF]

International Journal of Fertility and Sterility, 2023
The intracytoplasmic sperm injection (ICSI) has significantly improved male factor infertility treatment; however, complete fertilization failure still occurs in 1-5% of ICSI treatment cycles mainly due to oocyte activation failure.
Marziyeh Tavalaee, Nushin Naderi, Navid Esfandiari, Mohammad Hossein Nasr-Esfahani   +3 more
doaj   +1 more source

Molecular Analysis of DPY19L2, PICK1 and SPATA16 in Italian Unrelated Globozoospermic Men

Life, 2021
This study aims to evaluate genetic contribution and sperm DNA fragmentation (SDF) in a cohort of 18 unrelated globozoospermic Italian men (Group G). Semen samples were assessed according to the WHO 2010 Laboratory Manual and compared with 31 fertile ...
Fabiana Faja, Francesco Pallotti, Francesco Cargnelutti, Giulia Senofonte, Tania Carlini, Andrea Lenzi, Francesco Lombardo, Donatella Paoli   +7 more
doaj   +1 more source

Globozoospermia: Is There a Role for Varicocele Repair? [PDF]

Journal of Andrology, 2007
Varicocele is one of the most common abnormalities associated with male infertility. Although a great deal has been written regarding the pathophysiology and management of this lesion, the role of varicocele repair in selected clinical situations may be difficult to determine.
Randall B, Meacham, Hector, Chemes, Douglas, Carrell, Marc, Goldstein   +3 more
openaire   +2 more sources

Oxidative Stress-Related Programmed Cell Death in Male Infertility: Focussing on Ferroptosis. [PDF]

J Cell Mol Med
ABSTRACT Oxidative stress is a common occurrence in testicular cells of infertile men and is considered a significant cause of male reproductive dysfunction. The increase in reactive oxygen species (ROS) leads to impaired spermatogenesis by activating caspases and generating free radicals from mitochondria, resulting in DNA damage and cell death ...
Sanei-Ataabadi N, Aboutalebi F, Dormiani K, Nasr-Esfahani MH.   +3 more
europepmc   +2 more sources

INVESTIGATION OF GLOBOZOOSPERMIA’S MORPHOLOGICAL STRUCTURE AND DNA FRAGMENTATION IN OLIGOZOOSPERMIA CASES IN INFERTILE MALES

Middle East Journal of Science, 2022
Total globozoospermia is diagnosed by the presence of 100% round-headed spermatozoa without acrosomes. It is still unclear whether patients whose ejaculate contains both normal and globozoospermic cells (partial globozoospermia) suffer from a variation ...
Zuhal Çankırı, M. Akkuş, E. Yıldızhan, Dilara Akıncı, F. Aşır, O. Dede, Muhamet Afşin   +6 more
semanticscholar   +1 more source

Advancing ASMS with LC‐MS/MS for the discovery of novel PDCL2 ligands from DNA‐encoded chemical library selections

Andrology, Volume 11, Issue 5, Page 808-815, July 2023., 2023
Abstract Background A safe, effective, and reversible nonhormonal male contraceptive drug is greatly needed for male contraception as well as for circumventing the side effects of female hormonal contraceptives. Phosducin‐like 2 (PDCL2) is a testis‐specific phosphoprotein in mice and humans.
Qiuji Ye, Hassane Belabed, Yong Wang, Zhifeng Yu, Murugesan Palaniappan, Jian‐Yuan Li, Stacey A. Kalovidouris, Kevin R. MacKenzie, Mingxing Teng, Damian W. Young, Yoshitaka Fujihara, Martin M. Matzuk   +11 more
wiley   +1 more source

Loss of Profilin3 Impairs Spermiogenesis by Affecting Acrosome Biogenesis, Autophagy, Manchette Development and Mitochondrial Organization

Frontiers in Cell and Developmental Biology, 2021
Profilins (PFNs) are key regulatory proteins for the actin polymerization in cells and are encoded in mouse and humans by four Pfn genes. PFNs are involved in cell mobility, cell growth, neurogenesis, and metastasis of tumor cells.
Naila Umer, Lena Arévalo, Sharang Phadke, Keerthika Lohanadan, Gregor Kirfel, Dominik Sons, Denise Sofia, Walter Witke, Hubert Schorle   +8 more
doaj   +1 more source

Compound Heterozygous Mutations in FSIP2 Cause Morphological Abnormalities in Sperm Flagella Leading to Male Infertility

Andrologia, Volume 2023, Issue 1, 2023., 2023
Multiple morphological abnormalities of sperm flagella (MMAF) indicate severe teratozoospermia. The fibrous sheath interacting protein 2 (FSIP2) plays an important role in the normal construction of the flagella. In this study, a novel compound heterozygous mutation site of FSIP2, involving c.272_275delinsAGGTTTTTATA (p.L92Vfster74) and c ...
Fang Gao, Fei Ye, Qian Zhang, Yaoqiang Du, Weihai Xu, Ming Qi, Guolian Ding, Ling Zhang, Chongyi Shu, Xiaoyan Guo, Shishi Li, Min Zheng, Liannv Qiu, Amanda Zhou, Liya Sun, Jing Shu, Marta Olszewska   +16 more
wiley   +1 more source

Influence of ejaculatory abstinence period on semen quality of 5165 normozoospermic and oligozoospermic Nigerian men: A retrospective study

Health Science Reports, Volume 5, Issue 5, September 2022., 2022
Abstract Background and Aims Several studies have shown that the length of ejaculatory abstinence alters sperm quality. However, the available data are conflicting and none seems to exist in a Nigerian population. The present study aims to compare the semen quality in normozoospermic and oligozoospermic semen samples of a homogenous Nigerian population,
Roland E. Akhigbe, Moses A. Hamed, Sulagna Dutta, Pallav Sengupta   +3 more
wiley   +1 more source

A recurrent ZP1 variant is responsible for oocyte maturation defect with degenerated oocytes in infertile females

Clinical Genetics, Volume 102, Issue 1, Page 22-29, July 2022., 2022
Several genes are responsible for ovulatory disorders, especially for oocyte maturation defect with TUBB8 related to oocyte meiotic arrest, PATL2 associated to the retrieval of oocytes blocked at the germinal vesicle stage and ZP1 for which patients present no oocytes or atretic oocytes.
Corinne Loeuillet, Magali Dhellemmes, Caroline Cazin, Zine‐Eddine Kherraf, Selima Fourati Ben Mustapha, Raoudha Zouari, Nicolas Thierry‐Mieg, Christophe Arnoult, Pierre F. Ray   +8 more
wiley   +1 more source