Results 21 to 30 of about 2,311 (205)

Morphology of Partial Globozoospermia [PDF]

open access: yesJournal of Andrology, 2011
ABSTRACT: Total globozoospermia is a rare sperm morphology disorder that consists of 100% round‐headed, acrosomeless spermatozoa. There is also a larger group of patients whose sperm cells are partially acrosomeless. The aim of this investigation was to describe partial globozoospermia compared to total globozoospermia and normozoospermia.
Dam, A.H.D.M.   +7 more
openaire   +3 more sources

Molecular Analysis of DPY19L2, PICK1 and SPATA16 in Italian Unrelated Globozoospermic Men

open access: yesLife, 2021
This study aims to evaluate genetic contribution and sperm DNA fragmentation (SDF) in a cohort of 18 unrelated globozoospermic Italian men (Group G). Semen samples were assessed according to the WHO 2010 Laboratory Manual and compared with 31 fertile ...
Fabiana Faja   +7 more
doaj   +1 more source

Advancing ASMS with LC‐MS/MS for the discovery of novel PDCL2 ligands from DNA‐encoded chemical library selections

open access: yesAndrology, Volume 11, Issue 5, Page 808-815, July 2023., 2023
Abstract Background A safe, effective, and reversible nonhormonal male contraceptive drug is greatly needed for male contraception as well as for circumventing the side effects of female hormonal contraceptives. Phosducin‐like 2 (PDCL2) is a testis‐specific phosphoprotein in mice and humans.
Qiuji Ye   +11 more
wiley   +1 more source

Compound Heterozygous Mutations in FSIP2 Cause Morphological Abnormalities in Sperm Flagella Leading to Male Infertility

open access: yesAndrologia, Volume 2023, Issue 1, 2023., 2023
Multiple morphological abnormalities of sperm flagella (MMAF) indicate severe teratozoospermia. The fibrous sheath interacting protein 2 (FSIP2) plays an important role in the normal construction of the flagella. In this study, a novel compound heterozygous mutation site of FSIP2, involving c.272_275delinsAGGTTTTTATA (p.L92Vfster74) and c ...
Fang Gao   +16 more
wiley   +1 more source

Identification of a novel deletion mutation in DPY19L2 from an infertile patient with globozoospermia: a case report

open access: yesMolecular Cytogenetics, 2020
Background Male infertility is an increasing medical concern worldwide. In most cases, genetic factors are considered as the main cause of the disease.
You-zhu Li   +6 more
doaj   +1 more source

An Overview of The Globozoospermia as A Multigenic Identified Syndrome [PDF]

open access: yesInternational Journal of Fertility and Sterility, 2019
Acrosome plays an integral role during fertilization and its absence in individuals with globozoospermia leads to failure of in vitro fertilization (IVF) and oocyte activation post-intracytoplasmic sperm injection (ICSI).
Parastoo Modarres   +2 more
doaj   +1 more source

Influence of ejaculatory abstinence period on semen quality of 5165 normozoospermic and oligozoospermic Nigerian men: A retrospective study

open access: yesHealth Science Reports, Volume 5, Issue 5, September 2022., 2022
Abstract Background and Aims Several studies have shown that the length of ejaculatory abstinence alters sperm quality. However, the available data are conflicting and none seems to exist in a Nigerian population. The present study aims to compare the semen quality in normozoospermic and oligozoospermic semen samples of a homogenous Nigerian population,
Roland E. Akhigbe   +3 more
wiley   +1 more source

A recurrent ZP1 variant is responsible for oocyte maturation defect with degenerated oocytes in infertile females

open access: yesClinical Genetics, Volume 102, Issue 1, Page 22-29, July 2022., 2022
Several genes are responsible for ovulatory disorders, especially for oocyte maturation defect with TUBB8 related to oocyte meiotic arrest, PATL2 associated to the retrieval of oocytes blocked at the germinal vesicle stage and ZP1 for which patients present no oocytes or atretic oocytes.
Corinne Loeuillet   +8 more
wiley   +1 more source

Mfsd14a disruption causes globozoospermia [PDF]

open access: yes, 2016
The Mfsd14a gene, previously called Hiat1, encodes a transmembrane protein of unknown function with homology to the solute carrier protein family. To study the function of the MFSD14A protein, mutant mice (Mus musculus, strain 129S6Sv/Ev) were generated ...
Colledge, William Henry   +5 more
core   +2 more sources

Ultrastructural Morphology of Sperm from Human Globozoospermia [PDF]

open access: yesBioMed Research International, 2015
Globozoospermia is a rare disorder characterized by the presence of sperm with round head, lacking acrosome. Coiling tail around the nucleus has been reported since early human studies, but no specific significance has conferred it. By contrast, studies on animal models suggest that coiling tail around the nucleus could represent a crucial step of ...
RICCI, GIUSEPPE   +7 more
openaire   +5 more sources

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