Results 11 to 20 of about 2,192 (198)
Exome sequencing reveals novel causes as well as new candidate genes for human globozoospermia [PDF]
Human Reproduction, 2020 STUDY QUESTION Can exome sequencing identify new genetic causes of globozoospermia? SUMMARY ANSWER Exome sequencing in 15 cases of unexplained globozoospermia revealed deleterious mutations in seven new genes, of which two have been validated as causing ...
Manon S Oud +2 more
exaly +3 more sources
An Overview of The Globozoospermia as A Multigenic Identified Syndrome [PDF]
International Journal of Fertility and Sterility, 2019 Acrosome plays an integral role during fertilization and its absence in individuals with globozoospermia leads to failure of in vitro fertilization (IVF) and oocyte activation post-intracytoplasmic sperm injection (ICSI).
Parastoo Modarres +2 more
doaj +4 more sources
Journal of Human Reproductive Sciences, 2018 Globozoospermia, characterized by round-headed acrosomeless sperm, is a rare and severe form of teratozoospermia. We report a successful pregnancy in two cases of total globozoospermia after intracytoplasmic sperm injection (ICSI) with oocyte activation ...
Puneet Kaur Kochhar, Pranay Ghosh
doaj +3 more sources
Systems Biology in Reproductive Medicine, 2019 Sperm morphology and lipid profile have a relevant role in male fertility. We explore the status of the sperm centriole, essential structure for human fertilization and the role of fatty acid oxidation in globozoospermia, a rare sperm pathology causing ...
Elena Moretti +2 more
exaly +3 more sources
Globozoospermia revisited [PDF]
Human Reproduction Update, 2006 Abstract Globozoospermia is a rare (incidence <0.1%) but severe disorder in male infertility. Total globozoospermia is diagnosed by the presence of 100% round-headed spermatozoa lacking an acrosome. It is still unclear whether patients whose ejaculate contains both normal and globozoospermic cells (partial globozoospermia ...
Dam, A.H.D.M. +5 more
openaire +4 more sources
Association between total globozoospermia and sperm chromatin defects
Andrologia, 2018 Globozoospermia is a severe sperm morphological anomaly leading to primary infertility and low fertilisation following intracytoplasmic sperm injection (ICSI).
Marziyeh Tavalaee +1 more
exaly +4 more sources
Morphology of Partial Globozoospermia [PDF]
Journal of Andrology, 2011 ABSTRACT: Total globozoospermia is a rare sperm morphology disorder that consists of 100% round‐headed, acrosomeless spermatozoa. There is also a larger group of patients whose sperm cells are partially acrosomeless. The aim of this investigation was to describe partial globozoospermia compared to total globozoospermia and normozoospermia.
Dam, A.H.D.M. +7 more
openaire +4 more sources
Comprehensive investigation in patients affected by globozoospermia [PDF]
Andrology, 2015 SummaryThe aim of this study was to provide a comprehensive genetic/phenotypic characterization of subjects suffering infertility owing to sperm macrocephaly (n = 3) or globozoospermia (n = 9) and to investigate whether the patients’ genetic status was correlated with the alteration of various sperm parameters.
C, Coutton, C, Arnoult, P F, Ray
core +11 more sources
Reduction of truncated Kit Expression in Men with Abnormal Semen Parameters, Globozoospermia and History of Low or Fertilization Failure [PDF]
Cell Journal, 2019 Objective: Phospholipase C zeta 1 (PLCζ) is one of the main sperm factor involved in oocyte activation and other factors may assist this factor to induce successful fertilization. Microinjection of recombinant tr-kit, a truncated form of c-kit receptor,
Somayeh Haghighat +5 more
doaj +3 more sources
Clinical Genetics, 2022 The study identifies a novel biallelic pathogenic mutation in SPATA20 (c.1957+2T>A) in one infertile patient presenting with partial globozoospermia supporting its involvement in sperm head defects. The sperm phenotype described in our patient is however
G. Martinez +7 more
semanticscholar +2 more sources