Comprehensive investigation in patients affected by sperm macrocephaly and globozoospermia [PDF]
Andrology, 2015 SummaryThe aim of this study was to provide a comprehensive genetic/phenotypic characterization of subjects suffering infertility owing to sperm macrocephaly (n = 3) or globozoospermia (n = 9) and to investigate whether the patients’ genetic status was correlated with the alteration of various sperm parameters.
Lara Tamburrino +2 more
exaly +10 more sources
Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2014 Globozoospermia is a teratozoospermia that has not the ability of sperm to fertilize an oocyte with its own state, observed in infertile male patients with a ratio of 0.1%.
Deniz Aka Satar, Raziye Narin
doaj +3 more sources
Tex46 knockout male mice are sterile secondary to sperm head malformations and failure to penetrate through the zona pellucida. [PDF]
PNAS NexusEach year, infertility affects 15% of couples worldwide, with 50% of cases attributed to men. It is assumed that sperm head shape is important for sperm-zona pellucida (ZP) penetration but research has yet to elucidate why.
Fujihara Y +7 more
europepmc +3 more sources
Novel sperm selection device on the basis of microfluidics improves usable blastocyst rates, embryo morphology, and morphokinetic patterns: sibling cohort prospective study [PDF]
F&S ReportsObjective: To assess the performance of a novel microfluidic sperm selection device, SwimCount Harvester (SCH), compared with the Swim-up (SU) method, analyzing both sperm quality and the laboratory’s key performance indicators.
Fernando Meseguer, M.Sc. +6 more
doaj +2 more sources
Recommendations for Human Sperm Morphology Assessment in 2025: An Expert Review From the French BLEFCO Group. [PDF]
AndrologyABSTRACT Background Numerous publications have questioned the lack of analytical reliability and clinical relevance of sperm morphology assessment for infertility workup and before use of assisted reproductive techniques (ART). There is a huge variability in the performance and interpretation of this test.
Gatimel N +14 more
europepmc +2 more sources
Sperm parameters, protamine deficiency, and apoptosis in total globozoospermia
Iranian Journal of Reproductive Medicine, 2015 Background: Globozoospermia is a severe form of teratozoospermia (incidence < 0.1%) in infertile men that is characterized by round headed sperm and acrosomeless in semen.
Jalal Ghasemzadeh +6 more
doaj +2 more sources
Innovative all-in-one exome sequencing strategy for diagnostic genetic testing in male infertility: Validation and 10-month experience. [PDF]
AndrologyAbstract Background Current guidelines indicate that patients with extreme oligozoospermia or azoospermia should be tested for chromosomal imbalances, azoospermia factor (AZF) deletions and/or CFTR variants. For other sperm abnormalities, no genetic diagnostics are recommended.
Oud MS +12 more
europepmc +2 more sources
Assessment of DPY19L2 Deletion in Familial and Non-Familial Individuals with Globozoospermia and DPY19L2 Genotyping [PDF]
International Journal of Fertility and Sterility, 2016 Background Globozoospermia is a rare syndrome with an incidence of less than 0.1% among infertile men. Researchers have recently identified a large deletion, about 200 kbp, encompassing the whole length of DPY19L2 or mutations in SPATA16 and PICK1 genes ...
Parastoo Modarres +4 more
doaj +1 more source
Globozoospermia revisited [PDF]
Human Reproduction Update, 2006 Globozoospermia is a rare (incidence
Dam, A.H.D.M. +5 more
openaire +3 more sources
Assisted Oocyte Activation following Intracytoplasmic Sperm Injection: A Sensible Option for Infertile Couples with Severe Teratozoospermia [PDF]
International Journal of Fertility and Sterility, 2023 The intracytoplasmic sperm injection (ICSI) has significantly improved male factor infertility treatment; however, complete fertilization failure still occurs in 1-5% of ICSI treatment cycles mainly due to oocyte activation failure.
Marziyeh Tavalaee +3 more
doaj +1 more source