Globozoospermia: A Case Report and Systematic Review of Literature [PDF]
The World Journal of Men's Health, 2023 Purpose: Globozoospermia is a genetic syndrome characterized by the presence of round-headed spermatozoa and infertility due to the inability of these spermatozoa to fertilize the oocyte.
Andrea Crafa +4 more
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Atypical structure of the nuclear membrane, distribution of nuclear pores and lamin B1 in spermatozoa of patients with complete and partial globozoospermia [PDF]
Frontiers in GeneticsGlobozoospermia is a form of male infertility characterized by spermatozoa with spherical heads lacking acrosomes. The aim of this study was to evaluate ultrastructural and molecular defects in different types of globozoospermia.
Elizaveta Bragina +14 more
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A loss-of-function variant in SSFA2 causes male infertility with globozoospermia and failed oocyte activation [PDF]
Reproductive Biology and Endocrinology, 2022 Globozoospermia (OMIM: 102530) is a rare type of teratozoospermia ( A; p.R1224Q) in the patient. This variant significantly reduced the protein expression of SSFA2.
Gelin Huang +11 more
doaj +2 more sources
Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2014 Globozoospermia is a teratozoospermia that has not the ability of sperm to fertilize an oocyte with its own state, observed in infertile male patients with a ratio of 0.1%.
Deniz Aka Satar, Raziye Narin
doaj +3 more sources
An Overview of The Globozoospermia as A Multigenic Identified Syndrome [PDF]
International Journal of Fertility and Sterility, 2019 Acrosome plays an integral role during fertilization and its absence in individuals with globozoospermia leads to failure of in vitro fertilization (IVF) and oocyte activation post-intracytoplasmic sperm injection (ICSI).
Parastoo Modarres +2 more
doaj +3 more sources
Phospholipase Cζ, the Molecular Spark of Fertilization and Male Infertility: Insights from Bench to Bedside [PDF]
MedicinaPhospholipase C zeta (PLCζ) has emerged as a pivotal sperm-specific factor responsible for triggering oocyte activation, a process essential for successful fertilization and early embryogenesis.
Aris Kaltsas +6 more
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ELAPOR1 mediated vesicle traffic is required for acrosome biogenesis and male fertility in mice [PDF]
Cellular and Molecular Life SciencesSpermiogenesis is the post-meiotic differentiation and morphological change of the haploid spermatids. Acrosome biogenesis is one of the key events of spermiogenesis, which generates a specialized membranous organelle crucial for shaping the balanced ...
Runze Ding +7 more
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Globozoospermia is associated with chromatin structure abnormalities: Case report [PDF]
Human Reproduction, 2002 A recent study has shown normal sperm chromatin structure in a patient with globozoospermia. However, the poor success rate following intracytoplasmic sperm injection (ICSI) with the use of this sperm suggests that sperm nuclear abnormalities may be present.
Aldo E Calogero +2 more
exaly +4 more sources
Protein disulfide isomerase A6 (PDIA6) is essential for acrosome biogenesis and male fertility in mice [PDF]
Cell Communication and SignalingBackground The family of protein disulfide isomerases (PDIs) are thiol oxidoreductases located predominantly in the endoplasmic reticulum that catalyze thiol-disulfide exchange for normal protein folding.
Xiaofeng Yan +6 more
doaj +2 more sources
Acrosomal biogenesis in human globozoospermia: immunocytochemical, ultrastructural and proteomic studies [PDF]
Human Reproduction, 2012 Acrosome biogenesis is a key event in sperm differentiation that depends on the proper interaction between the Golgi complex and the nuclear envelope of early spermatids. We studied the development, structure and biochemical characteristics of human acrosomes in germ cells and spermatozoa from testicular biopsies and semen samples of fertile men and ...
Hector E Chemes +2 more
exaly +4 more sources