Results 91 to 100 of about 33,604 (226)

Central Diabetes Insipidus in Suprasellar Germ Cell Tumor Paradoxically Presenting With Oliguria

open access: yesClinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Central diabetes insipidus may present as oliguric acute kidney injury (AKI), particularly in patients with communication difficulties. While polyuria is common in AKI recovery, persistent or unexplained hypernatremia should prompt suspicion for alternative diagnoses such as unmasked diabetes insipidus to ensure timely recognition and ...
Karen Kin Nam Wong   +2 more
wiley   +1 more source

The Heparanase Inhibitor (Sulodexide) Decreases Urine Glycosaminoglycan Excretion and Mitigates Functional and Histological Renal Damages in Diabetic Rats

open access: yesActa Medica Bulgarica, 2019
Background/objectives: Recent data suggest a role for heparanase in several proteinuric conditions. An increased glomerular heparanase expression is associated with loss of heparan sulfate in the glomerular basement membrane (GBM). The aim of the present
Roshan-Milani S.   +2 more
doaj   +1 more source

Molecular and Cellular Events Mediating Glomerular Podocyte Dysfunction and Depletion in Diabetes Mellitus

open access: yesFrontiers in Endocrinology, 2014
The essential function of the kidney is to ensure formation of relatively protein-free ultra-filtrate, urine. The rate of filtration and composition of the primary renal filtrate is determined by the transport of fluid and solutes across the glomerular ...
Ram K Menon   +3 more
doaj   +1 more source

On the measurement of glomerular filtration rate: An odyssey into the milieu intérieur

open access: yes
Experimental Physiology, EarlyView.
Anders Møller Greve   +4 more
wiley   +1 more source

Diabetic Kidney Disease Progression Alleviated in Mice by ALKBH5‐Mediated UC‐MSCs‐Derived Exosomes That Inhibit TRAF6 m6A Modification and Promote M2 Macrophage Polarisation

open access: yesEndocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
ALKBH5‐modified UC‐MSCs‐derived exosomes (OE‐ALKBH5 Exo) inhibit the expression of M1 markers (iNOS, IL‐1β, TNF‐α, CD86) and enhance the expression of M2 markers (IL‐10, Arg‐1, CD206) by inhibiting the m6A methylation of TRAF6 and reducing its protein level and stability, thereby promoting M2 polarisation and alleviating the progression of DKD ...
Lei Li   +5 more
wiley   +1 more source

A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier

open access: yesNature Communications, 2019
The glomerular filtration barrier is a complex structure in charge of renal ultrafiltration. Here the authors present a glomerulus-on-a-chip for disease modelling and high-throughput drug screening where human podocytes and human glomerular endothelial ...
Astgik Petrosyan   +8 more
doaj   +1 more source

Lactobacillus Plantarum 6C Alleviates DSS‐Induced Colitis via Ligilactobacillus Enrichment‐Dependent Suppression of the PI3K‐AKT Signaling Pathway

open access: yesFood Frontiers, Volume 7, Issue 1, January 2026.
ABSTRACT Ulcerative colitis (UC) is a chronic intestinal inflammatory disease with complex pathogenesis. Previous studies have shown that probiotics alleviate UC by modulating the gut microbiome. Therefore, this study aimed to investigate the ameliorative effect of Lactobacillus plantarum 6C (L.
Jiashan Qin   +6 more
wiley   +1 more source

Mechanism of action of disulfiram and research advances in anti-glomerular basement membrane type glomerulonephritis

open access: yesLinchuang shenzangbing zazhi
Disulfiram is widely applied for treating chronic alcoholism. In recent years, researchers have proposed specific anti-cancer mechanisms by disulfiram, such as arresting the activity of acetaldehyde dehydrogenase (ALDH) and boosting intracellular ...
Yan-yu Zhang   +5 more
doaj   +1 more source

Renoprotective Effect of Coix lachryma‐jobi L. Seed Polysaccharides in Adenine‐Induced Chronic Renal Failure by Blocking Gut Urea Metabolism

open access: yesFood Frontiers, Volume 7, Issue 1, January 2026.
ABSTRACT Dietary soluble fiber may alleviate renal damage in chronic kidney disease (CKD) by promoting intestinal urea excretion, though the underlying mechanisms remain unclear. This study investigated the digestion, fermentation, and renoprotective effects of Coix lachryma‐jobi L.
Hongmei Yin   +9 more
wiley   +1 more source

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