Results 111 to 120 of about 108,933 (325)

Dysregulation of miR‐21‐5p in diabetic nephropathy and its role in inflammatory response

Journal of Diabetes Investigation, EarlyView.
The level of serum miR‐21‐5p was significantly upregulated in DN patients. The expression level of miR‐21‐5p increased with the aggravation of DN. Downregulation of miR‐21‐5p reduced HG‐induced cell proliferation. Downregulation OF miR‐21‐5P reduced HG‐induced levels of proinflammatory factors.
Yujiang Zhang, Qin Deng, Jianping Yi
wiley   +1 more source

Associação de doença do anticorpo anti-membrana basal glomerular com dermatomiosite e psoríase: relato de caso [PDF]

, 2010
CONTEXT: Anti-glomerular basement membrane (anti-GBM) antibody syndrome is characterized by deposition of anti-GBM antibodies on affected tissues, associated with glomerulonephritis and/or pulmonary involvement.
Buosi, Ana Letícia Pirozzi, Camargo, Cintia Zumstein, Machado, Natália Pereira, Oliveira, Ana Cecília Diniz, Pucinelli, Mário Luiz Cardoso, Souza, Alexandre Wagner Silva de   +5 more
core   +2 more sources

Red blood cell distribution width is associated with renal tubular injury in individuals with type 2 diabetes

Journal of Diabetes Investigation, EarlyView.
Overview of this research and pathological hypothesis. ABSTRACT Aims/Introduction Red blood cell distribution width (RDW) is a parameter of erythrocyte volume heterogeneity that has been traditionally used as an indicator of anemia and other hematopoietic abnormalities.
Kohsuke Miyataka, Yousuke Kaneko, Taiki Hori, Yuki Yamaguchi, Seijiro Tsuji, Tomoyo Hara, Hiroki Yamagami, Sumiko Yoshida, Toshiki Otoda, Tomoyuki Yuasa, Akio Kuroda, Takeshi Harada, Hirokazu Miki, Shingen Nakamura, Itsuro Endo, Munehide Matsuhisa, Ken‐ichi Matsuoka, Ken‐ichi Aihara   +17 more
wiley   +1 more source

Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice [PDF]

, 2019
Atypical hemolytic uremic syndrome (aHUS) is frequently associated in humans with loss-of-function mutations in complement-regulating proteins or gain-of-function mutations in complement-activating proteins.
Atkinson, John P, Barlow, Paul N, Cook, H. T, Cooke, Katie, Denton, Harriet, Kavanagh, David, Liszewski, M. K, Marchbank, Kevin J, Pappworth, Isabel Y, Pickering, Matthew C, Smith-Jackson, Kate, Yang, Yi   +11 more
core   +3 more sources

Distribution of basement membrane antigens in glomeruli of mice with autoimmune glomerulonephritis. [PDF]

, 1986
peer reviewedGlomerulonephritis was induced in mice by the repeated injection of human glomeruli or purified glomerular basement membrane. The glomerular basement membranes of nephritic animals were observed to develop subepithelial extensions, "spikes."
Andres, G., Brentjens, J. R., Foidart, Jean-Michel, Martin, G. R., Martinez-Hernandez, A., Matsuo, S.   +5 more
core   +1 more source

Clinical implications of imlifidase interference in antibody screening and transfusion management

Transfusion, EarlyView.
Abstract Background Imlifidase has received conditional approval from the EMA for desensitizing deceased donor kidney transplant recipients. It works by cleaving IgG into F(ab′)2 and Fc fragments, thereby reducing the risk of antibody‐mediated rejection. However, its impact on diagnostic assays remains understudied. Case Report We present the case of a
Zgjim Osmani, Aiko P. J. de Vries, Arjan Albersen   +2 more
wiley   +1 more source

Regeneration and Experimental Orthotopic Transplantation of a Bioengineered Kidney [PDF]

, 2014
Over 100,000 individuals in the United States currently await kidney transplantation, while 400,000 individuals live with end-stage kidney disease requiring hemodialysis. The creation of a transplantable graft to permanently replace kidney function would
Gilpin, Sarah, Gonzalez, Gabriel, Guyette, Jacques, Ott, Harald C, Song, Jeremy J, Vacanti, Joseph P   +5 more
core   +1 more source

Goodpasture’s Syndrome with Negative Anti-glomerular Basement Membrane Antibodies

European Journal of Case Reports in Internal Medicine, 2017
A young male patient with rapidly progressive and life-threatening pulmonary haemorrhage due to anti-glomerular basement membrane (anti-GBM) antibody disease without renal involvement repeatedly tested negative for serum anti-GBM antibodies.
Tjitske Berends-De Vries, Susan Boerma, Joan Doornabal, Bert Dikkeschei, Coen Stegeman, Thiemo Veneman   +5 more
doaj   +1 more source

Glomerular basement membrane disorders and the kidney

Medicine, 2011
The glomerular basement membrane (GBM) is the vital barrier between blood and glomerular filtrate. Diseases that damage it generally cause haematuria initially, but as architecture becomes disordered proteinuria becomes an increasing feature. Inflammatory glomerulonephritis most commonly does this, but genetic abnormalities of GBM components are ...
A Neil Turner, Eleri Williams
openaire   +2 more sources

World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis

Veterinary Dermatology, EarlyView.
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis, Gad Baneth, Silvia Colombo, Filipe Dantas‐Torres, Lluís Ferrer, Alessandra Fondati, Guadalupe Miró, Laura Ordeix, Domenico Otranto, Chiara Noli   +9 more
wiley   +1 more source