Results 131 to 140 of about 36,211 (244)
ABSTRACT Background Diabetic nephropathy is among the most critical long‐term complications linked to diabetes, substantially influencing both morbidity and mortality. Although it was once largely associated with adults, diabetic kidney disease (DKD) has now become a leading source of kidney complications among children worldwide.
Iran Malekzadeh +6 more
wiley +1 more source
Disulfiram is widely applied for treating chronic alcoholism. In recent years, researchers have proposed specific anti-cancer mechanisms by disulfiram, such as arresting the activity of acetaldehyde dehydrogenase (ALDH) and boosting intracellular ...
Yan-yu Zhang +5 more
doaj +1 more source
Clinical, genetic and molecular aspects of membranous nephropathy
Membranous Nephropathy (MN) is one of the leading causes of end-stage renal disease (ESRD). MN is an autoimmune disease in which autoantibodies target antigens at the level of the glomerular basement membrane.
Stanescu, H.C.
core
On the measurement of glomerular filtration rate: An odyssey into the milieu intérieur
Experimental Physiology, EarlyView.
Anders Møller Greve +4 more
wiley +1 more source
ABSTRACT IgA nephropathy (IgAN), the most common form of glomerulonephritis, is a major and growing public health issue. It results from intestinal barrier dysfunction that leads to mesangial deposition of pathogenic galactose‐deficient IgA1 (Gd‐IgA1) and renal inflammation.
Meng‐Si Li, Kai Liu
wiley +1 more source
A Case of Wegener`s Granulomatosis with Thin Glomerular Basement Membrane Disease [PDF]
Wegener`s granulomatosis is a necrotizing, granulomatous vasculitis that involves multiple organs including the upper and lower respiratory tract and the kidney.
이수곤, 박용범
core
Atorvastatin attenuates murine anti-glomerular basement membrane glomerulonephritis
Statins mediate many of their protective effects by lowering lipids as well as by modulating inflammation. Here, we studied their potential immunomodulatory role in renal inflammation using an autoimmune mouse model of anti-glomerular basement membrane ...
Wolf, Anna M. +7 more
core +1 more source
Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley +1 more source
Anti-glomerular basement membrane disease is a rare autoimmune disease characterized by rapidly progressive renal failure and/or pulmonary hemorrhage. The presence of severe crescentic glomerular inflammation with linear deposition of immunoglobulin G ...
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Current Status of Kidney Xenotransplantation in Basic Research
Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley +1 more source

