Results 141 to 150 of about 108,933 (325)

Effect and Mechanisms of Yiqi Jianpi Xiaoyu Prescription on Kidney Fibrosis on the Basis of Metabolomics and Experimental Validation

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
Our results demonstrate that YQJPXY alleviates fibrosis by regulating key metabolites, including adenosine, adenine, and inosine, and activates autophagy through the A2BR/cAMP/AMPK pathway. ABSTRACT The Yiqi Jianpi Xiaoyu prescription (YQJPXY) exhibits ameliorative effects on kidney fibrosis, but the underlying mechanism related to metabolism remains ...
Keda Lu, Liqing Ye, Wenze Jiang, Tianyang Cheng, Hong Xia, Peipei Zhang, Bingbing Zhang   +6 more
wiley   +1 more source

Mechanism of action of disulfiram and research advances in anti-glomerular basement membrane type glomerulonephritis

Linchuang shenzangbing zazhi
Disulfiram is widely applied for treating chronic alcoholism. In recent years, researchers have proposed specific anti-cancer mechanisms by disulfiram, such as arresting the activity of acetaldehyde dehydrogenase （ALDH） and boosting intracellular ...
Yan-yu Zhang, Xin Lyu, Xiao-guang Huang, Xiao-jun Ren, Xue Wang, Wei-min Yu   +5 more
doaj   +1 more source

Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids and its modification by Stearoyl-CoA desaturases and cyclic AMP [PDF]

, 2011
Podocyte apoptosis is a hallmark in the development and progression of diabetic nephropathy (DN). Several factors of the diabetic milieu are known to induce podocyte apoptosis. Currently, the role of free fatty acids (FFAs) for podocytopathy and podocyte
Sieber, Jonas
core   +1 more source

Two Sides of the Same Coin—Mechanistic Insight, Diagnostic Application and Therapeutic Translation of Bacterial and Host‐Derived Extracellular Vesicles

Journal of Extracellular Biology, Volume 4, Issue 11, November 2025.
ABSTRACT Extracellular vesicles (EVs) have gained increasing attention in recent years due to their pivotal role in both health and disease. Emerging from both eukaryotic and prokaryotic cells, EVs serve as essential mediators of intercellular communication, exceeding the simplistic interactions observed with individual molecules. In this comprehensive
Philipp Arnold, Fanni Annamária Boros, Jochen Mattner, Gerald Seidel, Chaofan Liu, Inga Viktoria Hensel, Jan Van Deun, Raphael Schwendner, Janina Müller‐Deile, Nina Sopel, Andreas Ramming, Mario R. Angeli, Simon Rauber, Cláudia Vilhena, Andreas Baur, Stefan Wirtz, Klaus Überla, Heiko Reutter, Linda‐Marie Mulzer, Alina C. Hilger, Friederike Zunke, Wei Xiang, Gregor Fuhrmann, Claudia Günther   +23 more
wiley   +1 more source

Glomerular Basement Membrane

Definitions, 2020

semanticscholar   +1 more source

The Presence of Anti-Glomerular Basement Membrane Antibodies in Peripheral Blood [PDF]

, 1969
John J. McPhaul, Frank J. Dixon
openalex   +1 more source

Aryl Hydrocarbon Receptor in Health and Disease

MedComm, Volume 6, Issue 11, November 2025.
Based on the structure and ligands of AhR, this review introduces the AhR‐related signaling pathways and their roles in health and diseases. Agonists and antagonists of AhR as well as new strategies for treatment using the microbial–AhR axis are summarized. A prospect was made for the future use of AhR as a therapeutic target.
Haonan Li, Yufeng Fan, Jizheng Liu, Shumin Dong, Bin Wen, Yunfei Zhang, Xiaocui Wang, Xuemei Duan, Ying Hu, Ze Yan, Huifeng Shang, Yukai Jing   +11 more
wiley   +1 more source

Nodular glomerulosclerosis with anti-glomerular basement membrane-like glomerulonephritis; a distinct pattern of kidney injury observed in smokers [PDF]

, 2014
Background: Cigarette smoking has recently been recognized as a risk factor for developing nodular glomerulosclerosis and has also been frequently encountered in patients with anti-glomerular basement membrane (anti-GBM) disease.
Batal, Ibrahim, Bijol, Vanesa, Popham, Sandy, Reyes, Daisy B.   +3 more
core   +1 more source

Blockade of cannabinoid CB1 receptors potentiates the anti‐fibrotic effects mediated by SGLT2 inhibition in a mouse model of diabetic nephropathy

British Journal of Pharmacology, Volume 182, Issue 21, Page 5355-5377, November 2025.
Background and purpose Diabetic nephropathy (DN) is a common complication of diabetes. Current treatments include renin‐angiotensin‐aldosterone system (RAAS) blockers and sodium‐glucose co‐transporter 2 (SGLT2) inhibitors. The cannabinoid CB1 receptor is a potential therapeutic target.
Océane Pointeau, Awa Isma Ba, Audrey Geissler, Romain Barbosa, Abhishek Basu, Arif Muhammad, Marina Nivot, Maéva Loriot, Julia Leemput, Patricia Passilly‐Degrace, Sébastien Causse, Laurent Demizieux, Hélène François, Bruno Vergès, Jianmin Duan, Geneviève Gaucher, Michael Harvey, Pascal Degrace, Glenn Crater, Resat Cinar, Tony Jourdan   +20 more
wiley   +1 more source

Foetal disruptive brain injuries: Diagnosing the underlying pathogenetic mechanisms with cranial ultrasonography

Developmental Medicine &Child Neurology, Volume 67, Issue 11, Page 1383-1408, November 2025.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16431 Abstract Antenatal destructive events affecting the central nervous system of the foetus lead to disruptive brain lesions that are often associated with impaired neurodevelopment.
Ana Alarcón, Nuria Carreras, Tobias Muehlbacher, Dídac Casas‐Alba, Roberta Arena, Paola Roca‐Llabrés, Juan Navarro‐Morón, Linda S. de Vries, Paul Govaert, the EurUS.Brain group, Thais Agut, Roberta Arena, Ana Alarcón, Juan Arnáez, Marco Bartocci, Isabel Benavente‐Fernández, María Carmen Bravo, Fernando Cabañas, Nuria Carreras, Olivier Claris, Jeroen Dudink, Monica Fumagalli, Alfredo García‐Alix, Paul Govaert, Sandra Horsch, Simón Lubián, Tobias Muehlbacher, Alessandro Parodi, Adelina Pellicer, Luca Ramenghi, Charles C. Roehr, Simone Schwarz, Sylke Steggerda, Eva Valverde   +33 more
wiley   +1 more source