Results 11 to 20 of about 107,331 (315)
Complexities of the glomerular basement membrane [PDF]
The glomerular basement membrane (GBM) is a key component of the glomerular capillary wall and is essential for kidney filtration. The major components of the GBM include laminins, type IV collagen, nidogens and heparan sulfate proteoglycans. In addition, the GBM harbours a number of other structural and regulatory components and provides a reservoir ...
Richard W. Naylor+3 more
openaire +4 more sources
Anti–Glomerular Basement Membrane Disease
Anti-glomerular basement membrane (anti-GBM) disease is a rare autoimmune small vessel vasculitis characterized by autoreactivity to antigens in type IV collagen chains expressed in glomerular and alveolar basement membrane. The detection of circulating anti-GBM antibodies, which are shown to be directly pathogenic, is central to disease diagnosis ...
Stephen P. McAdoo+2 more
openaire +5 more sources
Anti-DNA autoantibodies initiate experimental lupus nephritis by binding directly to the glomerular basement membrane in mice [PDF]
The strongest serological correlate for lupus nephritis is antibody to double-stranded DNA, although the mechanism by which anti-DNA antibodies initiate lupus nephritis is unresolved.
Krishnan, Meera R.+2 more
core +2 more sources
Glomerular basement membrane and related glomerular disease [PDF]
The glomerular basement membrane (GBM) is lined by fenestrated endothelium from the capillary-lumen side and by interdigitating foot processes of the podocytes from the urinary- space side. These three layers of the glomerular capillary wall constitute the functional unit of the glomerular filtration barrier.
Ying Maggie Chen, Jeffrey H. Miner
openaire +4 more sources
The glomerular basement membrane [PDF]
The kidney's glomerular filtration barrier consists of two cells-podocytes and endothelial cells-and the glomerular basement membrane (GBM), a specialized extracellular matrix that lies between them. Like all basement membranes, the GBM consists mainly of laminin, type IV collagen, nidogen, and heparan sulfate proteoglycan.
J. Miner
openaire +4 more sources
Collagen IV is a major component of basement membranes, and mutations in COL4A1, which encodes collagen IV alpha chain 1, cause a multisystemic disease encompassing cerebrovascular, eye and kidney defects.
Frances E. Jones+11 more
doaj +2 more sources
The glomerular basement membrane as a barrier to albumin [PDF]
The glomerular basement membrane (GBM) is the central, non-cellular layer of the glomerular filtration barrier that is situated between the two cellular components--fenestrated endothelial cells and interdigitated podocyte foot processes. The GBM is composed primarily of four types of extracellular matrix macromolecule--laminin-521, type IV collagen ...
Jeffrey H. Miner, Jung Hee Suh
openaire +4 more sources
Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane [PDF]
Despite being engineered to avoid renal clearance, many cationic polymer (polycation)-based siRNA nanoparticles that are used for systemic delivery are rapidly eliminated from the circulation.
Andrews+26 more
core +4 more sources
Laminin distribution in developing glomerular basement membranes
The renal glomerular basement membrane (GMB) separates two distinctly different cell layers: the vascular endothelium, and visceral epithelial podocytes. When initial vascularization of the forming glomerulus takes place during nephrogenesis, the early GBM forms by fusion of a dual basement membrane between endothelial cells and podocytes.
Dale R. Abrahamson, Patricia L. St. John
openalex +4 more sources
Anti-Glomerular Basement Membrane Disease [PDF]
Anti–glomerular basement membrane (anti-GBM) disease is a rare autoimmune disorder characterized by rapidly progressive glomerulonephritis (RPGN) with diffuse crescentic formation on renal biopsy, and it is a well-characterized cause of glomerulonephritis.
Kouichi Hirayama, Kunihiro Yamagata
core +4 more sources