Results 11 to 20 of about 108,933 (325)

Complexities of the glomerular basement membrane [PDF]

Nature Reviews Nephrology, 2020
The glomerular basement membrane (GBM) is a key component of the glomerular capillary wall and is essential for kidney filtration. The major components of the GBM include laminins, type IV collagen, nidogens and heparan sulfate proteoglycans. In addition, the GBM harbours a number of other structural and regulatory components and provides a reservoir ...
Richard W. Naylor, Mychel R. P. T. Morais, Mychel R. P. T. Morais, Rachel Lennon   +3 more
openaire   +4 more sources

Clogging of the glomerular basement membrane. [PDF]

The Journal of cell biology, 1982
The negative charges of the sulfated glycosaminoglycans (GAGs) of the glomerular basement membrane (GBM) were differentially neutralized by perfusin with high molarity buffers in order to determine whether or not these charges protect the GBM from being clogged by circulating plasma macromolecules.
Yashpal S. Kanwar, Lionel J. Rosenzweig
openaire   +4 more sources

Anti-Glomerular Basement Membrane Disease in a 10-year-old Child: A Case Report [PDF]

Journal of Nepal Medical Association, 2023
Anti-glomerular basement membrane disease is an extremely uncommon entity in children. It has an incidence of 0.5 to 1 per million per year in adults and is even more uncommon in children.
Md Firoz Anjum, Sajal Twanabasu, Sailesh Shrestha, Tashi Anjuk Lama, Dipendra Magrati   +4 more
doaj   +2 more sources

Anti–Glomerular Basement Membrane Disease

Rheumatic Disease Clinics of North America, 2018
Anti-glomerular basement membrane (anti-GBM) disease is a rare autoimmune small vessel vasculitis characterized by autoreactivity to antigens in type IV collagen chains expressed in glomerular and alveolar basement membrane. The detection of circulating anti-GBM antibodies, which are shown to be directly pathogenic, is central to disease diagnosis ...
Stephen P. McAdoo, Stephen P. McAdoo, Kavita Gulati   +2 more
openaire   +5 more sources

Anti-glomerular basement membrane disease superimposed on membranous nephropathy after coronavirus disease 2019: A case report [PDF]

Journal of International Medical Research
Membranous nephropathy concurrent with anti-glomerular basement membrane disease is rarely reported. Acute kidney injury is prominent when these diseases coexist. Coronavirus disease 2019 may trigger this superimposition.
Rongrong Hu, Siqi Tang, Chao Li, Yizhen Wei, Peng Xia, Ke Zheng, Yan Qin   +6 more
doaj   +2 more sources

Glomerular basement membrane and related glomerular disease [PDF]

Translational Research, 2012
The glomerular basement membrane (GBM) is lined by fenestrated endothelium from the capillary-lumen side and by interdigitating foot processes of the podocytes from the urinary- space side. These three layers of the glomerular capillary wall constitute the functional unit of the glomerular filtration barrier.
Ying Maggie Chen, Jeffrey H. Miner
openaire   +4 more sources

THE ROLE OF ANTI-GLOMERULAR BASEMENT MEMBRANE ANTIBODY IN THE PATHOGENESIS OF HUMAN GLOMERULONEPHRITIS [PDF]

Journal of Experimental Medicine, 1967
These observations established the presence of anti-GBM antibodies in the sera and/or kidneys of six humans with glomerulonephritis. Further, it seems clear that these antibodies do combine with the host's glomeruli in vivo and with GBM antigen of ...
R. Lerner, R. Glassock, F. Dixon
semanticscholar   +2 more sources

A rare case of sero-negative anti-glomerular basement membrane disease combined with diabetic nephropathy and literature review [PDF]

Renal Failure
We report a case of a 59-year-old male who exhibited an insidious onset of hematuria, nephrotic syndrome, and mild renal dysfunction, with negative serum anti-glomerular basement membrane antibodies.
Wenbo Wang, Weiyi Guo, Xiaoyi Xu, Nan Ye, Lingqiang Kong, Guoqin Wang, Hong Cheng   +6 more
doaj   +2 more sources

The glomerular basement membrane as a barrier to albumin [PDF]

Nature Reviews Nephrology, 2013
The glomerular basement membrane (GBM) is the central, non-cellular layer of the glomerular filtration barrier that is situated between the two cellular components--fenestrated endothelial cells and interdigitated podocyte foot processes. The GBM is composed primarily of four types of extracellular matrix macromolecule--laminin-521, type IV collagen ...
Jeffrey H. Miner, Jung Hee Suh
openaire   +4 more sources

ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in mice

Disease Models & Mechanisms, 2016
Collagen IV is a major component of basement membranes, and mutations in COL4A1, which encodes collagen IV alpha chain 1, cause a multisystemic disease encompassing cerebrovascular, eye and kidney defects.
Frances E. Jones, Matthew A. Bailey, Lydia S. Murray, Yinhui Lu, Sarah McNeilly, Ursula Schlötzer-Schrehardt, Rachel Lennon, Yoshikazu Sado, David G. Brownstein, John J. Mullins, Karl E. Kadler, Tom Van Agtmael   +11 more
doaj   +2 more sources