Results 51 to 60 of about 28,785 (230)

Randomised, phase 1 evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of iptacopan in healthy volunteers

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Overactivation of the alternative pathway (AP) underlies several diseases. Iptacopan is an oral, first‐in‐class, highly potent specific inhibitor of factor B, a key AP protease. Experimental Approach The analysis included data from two phase 1 randomised, volunteer‐blinded, placebo‐controlled studies: Study 1, a single ...
Irina Baltcheva, Guido Junge, Kenneth Kulmatycki, Robert Schmouder, Anna Schubart, Marie‐Anne Valentin   +5 more
wiley   +1 more source

Henoch-Schönlein purpura in an older man presenting as rectal bleeding and IgA mesangioproliferative glomerulonephritis: a case report [PDF]

, 2011
Introduction Henoch-Schönlein purpura is the most common systemic vasculitis in children. Typical presentations are palpable purpura, abdominal pain, arthritis, and hematuria.
Wisit Cheungpasitporn, Teeranun Jirajariyavej, Charles B Howarth, Raquel M Rosen   +3 more
core   +1 more source

Clinical significance of renal histological diagnosis in patients with type 2 diabetes and proteinuria atypical for diabetic nephropathy

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Background/Aim Most patients with proteinuria are considered to have typical diabetic nephropathy (DN). However, when proteinuria occurs without diabetic retinopathy, with hematuria, or persists despite strict glycemic and blood pressure control, it is considered atypical for DN and warrants further evaluation for non‐DN via kidney biopsy ...
Shogo Kuwagata, Masami Chin‐Kanasaki, Aki Yamada, Tomonori Sakae, Nahomi Ishimoto, Yoshimi Imamura‐Uehara, Kosuke Yamahara, Mako Yasuda‐Yamahara, Sho Sugahara, Yuki Tanaka‐Sasaki, Natsumi Kuwata, Kimihiro Nishimura, Koichiro Murata, Itsuko Miyazawa, Shogo Ida, Natsuko Ohashi, Shinji Kume   +16 more
wiley   +1 more source

Clinicopathological characteristics and predictors of renal outcomes in diffuse crescentic glomerulonephritis : a retrospective single-center study from Western China

BMC Nephrology
Background The factors influencing diffuse crescentic glomerulonephritis renal survival and prognosis remain uncertain. Additionally, there’s no literature on the clinical outcomes of IgA nephropathy, lupus nephritis, and IgA vasculitis nephritis in type
Shan Wen, Shasha Chen, Yingying Lin, Guisen Li, Ping Zhang, Wei Wang   +5 more
doaj   +1 more source

Long-term prognosis in chronic primary glomerulonephritides [PDF]

, 2012
Chronic primary glomerulonephritides (CPGN) is a group of diseases characterised by leakage of proteins and/or erythrocytes into the urine with or without decreased glomerular filtration rate (GFR), hypertension, oedema, hyperlipidemia and low serum ...
Bjørneklett, Rune Oskar
core   +1 more source

LDH-IgA COMPLEXES ASSOCIATED WITH IgA GLOMERULONEPHRITIS

The KITAKANTO Medical Journal, 1983
A 15-year-old boy was admitted to the hospital because of increased serum LDH activity and microhematuria. The gel filtration and the immunoelectrophoresis revealed the presence of high molecular LDH-IgA complex, while the diagnosis of IgA glomerulonephritis was established by renal biopsy.
TAKASHI IIZUKA, HISAO KUMAKURA, SHOICHI TOMONO, TADASHI SUZUKI, KAZUHIKO MURATA, YOSHIO USHIJIMA, MASAO ARAI, SOSUKE OIKE   +7 more
openaire   +2 more sources

Global kidney health: Are we failing the silent pandemic?

Journal of Internal Medicine, EarlyView.
Abstract Chronic kidney disease (CKD), although not infectious, has a sharply rising global incidence, alarming rates of death and disability, and the potential to disrupt health systems and economies. Thus, it demands the urgency and global attention of past pandemics.
Taewon Yi, Daniel V. O'Hara, Adeera Levin   +2 more
wiley   +1 more source

A Case of Self-Limiting Crescentic Immunoglobulin A Glomerulonephritis Associated with Sternoclavicular Arthritis

Case Reports in Nephrology and Dialysis, 2018
Immunoglobulin (Ig) A glomerulonephritis (GN) is a heterogeneous disease affected by various factors. Genetic and other factors “hit” DNA, causing IgA malformation and ultimately glomerular injury.
Yoko Fujita, Tomo Suzuki, Wei Han, Shiika Watanabe, Koichi Yahagi, Mayumi Nakata, Takeshi Okamoto, Daisuke Ichikawa, Junki Koike, Yugo Shibagaki   +9 more
doaj   +1 more source

Clinical implications of imlifidase interference in antibody screening and transfusion management

Transfusion, EarlyView.
Abstract Background Imlifidase has received conditional approval from the EMA for desensitizing deceased donor kidney transplant recipients. It works by cleaving IgG into F(ab′)2 and Fc fragments, thereby reducing the risk of antibody‐mediated rejection. However, its impact on diagnostic assays remains understudied. Case Report We present the case of a
Zgjim Osmani, Aiko P. J. de Vries, Arjan Albersen   +2 more
wiley   +1 more source

Assessment of Ten-Year-Long Results of Kidney Biopsies Performed on Children in the Thrace Region of Turkey

Balkan Medical Journal, 2016
Background: Many children with kidney diseases can be diagnosed and treated without a biopsy. However, biopsy is a valuable method for the diagnostic and prognostic evaluation of children with kidney diseases.
Neşe Özkayın, Gökçe Çıplak, Ufuk Usta, Hakan Gençhellaç, Osman Temizöz   +4 more
doaj   +1 more source