Results 61 to 70 of about 21,254 (226)

Forsythiaside A Alleviates Kidney Injury and Intestinal Epithelium Dysfunction in IgA Nephropathy by Inhibiting TLR4/NF‐κB Signaling

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 6, June 2026.
ABSTRACT IgA nephropathy (IgAN), the most common form of glomerulonephritis, is a major and growing public health issue. It results from intestinal barrier dysfunction that leads to mesangial deposition of pathogenic galactose‐deficient IgA1 (Gd‐IgA1) and renal inflammation.
Meng‐Si Li, Kai Liu
wiley   +1 more source

Assessment of Ten-Year-Long Results of Kidney Biopsies Performed on Children in the Thrace Region of Turkey

Balkan Medical Journal, 2016
Background: Many children with kidney diseases can be diagnosed and treated without a biopsy. However, biopsy is a valuable method for the diagnostic and prognostic evaluation of children with kidney diseases.
Neşe Özkayın, Gökçe Çıplak, Ufuk Usta, Hakan Gençhellaç, Osman Temizöz   +4 more
doaj   +1 more source

Randomised, phase 1 evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of iptacopan in healthy volunteers

British Journal of Pharmacology, Volume 183, Issue 11, Page 2874-2889, June 2026.
Abstract Background and Purpose Overactivation of the alternative pathway (AP) underlies several diseases. Iptacopan is an oral, first‐in‐class, highly potent specific inhibitor of factor B, a key AP protease. Experimental Approach The analysis included data from two phase 1 randomised, volunteer‐blinded, placebo‐controlled studies: Study 1, a single ...
Irina Baltcheva, Guido Junge, Kenneth Kulmatycki, Robert Schmouder, Anna Schubart, Marie‐Anne Valentin   +5 more
wiley   +1 more source

IgA-Dominant Postinfectious Glomerulonephritis: A New Twist on an Old Disease

, 2011
IgA-dominant acute postinfectious glomerulonephritis (APIGN) is an increasingly recognized morphologic variant of APIGN, particularly in the elderly. In contrast to classic APIGN, in which there is typically glomerular deposition of IgG and C3 or C3 only,
Vivette D. D’Agati, Samih H. Nasr
core   +1 more source

Late Presentation of de Novo Proliferative Glomerulonephritis With Monoclonal IgG Deposits in a Renal Allograft: A Rare Case With an Unusual Clinical Course

Nephrology, Volume 31, Issue 6, June 2026.
ABSTRACT Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is a form of monoclonal gammopathy of renal significance (MGRS) in which monoclonal immunoglobulin deposits are found within the glomerulus, without involvement of other renal compartments.
Hayley J. Duxbury, David A. Brown, Adrian Y. S. Lee, Germaine Wong, Fiona Kwok, Seethalakshmi Viswanathan   +5 more
wiley   +1 more source

Origin of poorly galactosylated IgA1 other than mucosa: a viewpoint from a report on patient with IgA vasculitis

Renal Failure
Patients presenting monoclonal gammopathy of renal significance (MGRS) and IgA vasculitis collectively have rarely been reported. This study reports one patient with monoclonal IgA and λ, and with IgA positive-mesangial proliferative glomerulonephritis ...
Manxia Huang, Jian Cao, Yangpu Li, Hua Xu, Manliu Wang, Yihou Zheng, Mumin Shao, Youjia Zeng, Jicheng Lv   +8 more
doaj   +1 more source

Changes in the diagnosis of glomerular diseases in east China: a 15-year renal biopsy study

Renal Failure, 2018
Background: There have been some gradual changes in the distribution of renal biopsy pathological diagnoses during recent years. This study aimed to show changes in renal disease prevalence in China by investigating 10 patients diagnosed at our Kidney ...
Qin Zhou, Xin Yang, Meifang Wang, Huiping Wang, Jie Zhao, Yan Bi, Xiayue Wang, Jihong Yao, Ying Chen, Chuan Lin, Xishao Xie, Hong Jiang, Jianghua Chen   +12 more
doaj   +1 more source

Successful treatment of a patient with posttransplant IgA nephropathy with targeted release formulation of budesonide

Saudi Journal of Kidney Diseases and Transplantation, 2020
Recurrence of glomerulonephritis is the third-leading cause of allograft loss. Graft loss due to IgA nephropathy occurs in 10% at 10-year follow-up.
Umesh Lingaraj, Kishan Aralapuram, Sreedhara Chikkanayakanhalli, Akila Vishwanathan, Mahesha Vankalakunti   +4 more
doaj   +1 more source

Secondary immunoglobulin A nephropathy with gross hematuria leading to rapidly progressive glomerulonephritis following severe acute respiratory syndrome coronavirus 2 vaccination: a case report

BMC Nephrology, 2023
Background The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been followed by many reports of the development and relapse of autoimmune diseases associated with SARS-CoV-2 vaccination.
Miyako Fukuda, Tomohiro Kaneko, Takahiro Kawai, Hiromasa Ishii, Akira Shimizu   +4 more
doaj   +1 more source

Pauci-immune crescentic glomerulonephritis associated with ANCA of IgA class

, 2009
Pauci-immune renal vasculitis is associated strongly with antineutrophil cytoplasmic antibodies (ANCAs) of the immunoglobulin G (IgG) class, which are detected in 80% to 90% of affected patients.
Bollee, G., Gilardin, L., El-Ghoul, B., Suarez, F., de Serre, N. P., Fakhouri, F., Alyanakian, M. A., Noel, L. H., Lesavre, P., Royal, V.   +9 more
core   +1 more source