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The Pathogenesis of Focal Segmental Glomerulosclerosis [PDF]

Advances in Chronic Kidney Disease, 2014
Focal segmental glomerulosclerosis (FSGS) is a histologic pattern of injury on kidney biopsy that can arise from a diverse range of causes and mechanisms. Although primary and secondary forms are described based on the underlying cause, there are many common factors that underlie the development of this segmental injury.
J Ashley, Jefferson, Stuart J, Shankland
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Familial focal segmental glomerulosclerosis

Current Opinion in Nephrology and Hypertension, 2001
There is increasing recognition of the importance of genetic factors in the development of focal segmental glomerulosclerosis and related proteinuric disorders. Recently, four genes have been identified which, when defective, cause focal segmental glomerulosclerosis or nephrosis.
J, Kaplan, M R, Pollak
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Focal Segmental Glomerulosclerosis

Nihon rinsho. Japanese journal of clinical medicine, 2004
Focal segmental glomerulosclerosis (FSGS) is one of the major causes of nephrotic syndrome in adult as well as in the children. Untreated or steroid-resistant primary FSGS often shows a progressive renal insufficiency and reaches to end-stage renal failure.
Yukio, Yuzawa, Seiichi, Matsuo
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Focal segmental glomerulosclerosis in children

Current Opinion in Pediatrics, 1995
Idiopathic focal segmental glomerulosclerosis is a histologic diagnosis that usually presents as the nephrotic syndrome but, unlike minimal change disease, often leads to renal failure in children. Standard therapies used to treat the proteinuria are often futile, and thus patients are at risk for the multiple complications resulting from persistent ...
E, Ingulli, A, Tejani
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Treatment of focal segmental glomerulosclerosis

Expert Opinion on Pharmacotherapy, 2005
Focal segmental glomerulosclerosis (FSGS) is not a disease, but a lesion affecting the podocyte. Secondary FSGS may be due to a host of various factors, and patients are rarely nephrotic, requiring symptomatic treatment only. The best prognostic feature of nephrotic FSGS is its response to corticosteroids.
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Problems with 'focal segmental glomerulosclerosis'

Pediatric Nephrology, 2011
The term 'focal segmental glomerulosclerosis (FSGS)' has been applied to many different conditions. All classifications of 'FSGS', including those describing 'variants', perpetuate the misconceptions that the entities included have something in common and that the term 'FSGS' has some value.
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Focal and Segmental Glomerulosclerosis

2013
Focal and segmental glomerulosclerosis (FSGS) is a pathologic diagnosis characterized by a signature pathologic lesion, grossly defined by the pathologic finding of sclerosis in parts of the tufts involving some but not all glomeruli. It can be primary or due to secondary causes.
Moumita Barua, Martin R. Pollak
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Idiopathic focal segmental glomerulosclerosis

Seminars in Nephrology, 2003
Idiopathic focal segmental glomerulosclerosis (FSGS) is a primary glomerular disease that essentially represents a form of chronic, progressive renal fibrosis for which there is no discernible cause. Often presenting with or eventually manifesting the nephrotic syndrome, this disease is increasing in incidence in both children and adults.
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Focal Segmental Glomerulosclerosis

American Journal of Kidney Diseases, 1998
Over the last 2 decades, we have learnt that focal segmental glomerulosclerosis (FSGS) is a ubiquitous phenomenon underlying the progressive deterioration of many different types of renal diseases in both pediatric and adult populations. FSGS may also be the primary renal lesion, whether in new disease entities such as glycogen storage disease and ...
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Focal and Segmental Glomerulosclerosis

1987
Fahr (1) and Rich (2) described children who had lipoid nephrosis but demonstrated glomerular sclerosis on examination of renal specimens at autopsy. It was not until the early 1970’s that this lesion began to attract considerable attention based on reports by Hayslett (3) and others (4, 5, 6).
Karen M. Gaudio, Norman J. Siegel
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