Results 111 to 120 of about 46,505 (249)

Pathways for glomerular macromolecule filtration: A mathematical model for transport across glomerular filtration surface, mesangium and shear-induced shunts. [PDF]

PLoS Comput Biol
Punyaratabandhu N, Pankoh T, Roongthumskul Y, Dechadilok P, Katavetin P.   +4 more
europepmc   +1 more source

Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients

British Journal of Clinical Pharmacology, EarlyView.
Aim Imatinib pharmacokinetics exhibit large interindividual variability because of differences in CYP3A4 activity—the main imatinib‐metabolizing enzyme. While therapeutic drug monitoring is effective, it requires steady‐state conditions and frequent sampling.
Anna Sofie Buhl Rasmussen, Mathilde Rønne Koch, Cecilie Utke Rank, Christen Lykkegaard Andersen, Allan Weimann, Maria Thastrup, Tianwu Yang, Trine Meldgaard Lund, Ib Jarle Christensen, Flemming Nielsen, Tore Bjerregaard Stage, Sara Bisgaard Jensen, Mette Klarskov Andersen, Kjeld Schmiegelow, Kim Dalhoff   +14 more
wiley   +1 more source

Beat- and Side-family cell-surface molecules are expressed combinatorially in the partner neurons of the olfactory circuit in Drosophila. [PDF]

PLoS Biol
Duan Q, Okuwa S, Estrella R, Yeung C, Chen YD, Rio LQ, Du C, Vien KM, Volkan PC.   +8 more
europepmc   +1 more source

Evaluation of a pantoprazole and 4‐desmethylpantoprazole‐sulfate metabolic ratio as a novel CYP2C19 phenotyping method

British Journal of Clinical Pharmacology, EarlyView.
Aims CYP2C19 is one of the most important pharmacogenes, and its activity is highly variable due to factors such as genetics or drug–drug interactions. Due to the lack of an appropriate endogenous CYP2C19 biomarker, surrogate methods to assess its activity are warranted.
Julian Peter Müller, Vladimir N. Belov, Sabrina Yamoune, Bob Miller, Mohammed Hasoumi, Jolanta Tupiec, Thea Laurentius, L. Cornelius Bollheimer, Julia C. Stingl, Katja S. Just   +9 more
wiley   +1 more source

Modulation of habenula axon terminals supports action-outcome associations in larval zebrafish. [PDF]

Nat Commun
Paoli E, Palieri V, Shenoy A, Portugues R.   +3 more
europepmc   +1 more source

Population pharmacokinetics and pharmacodynamics of canagliflozin in paediatric patients with type 2 diabetes mellitus

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Canagliflozin was recently approved in type 2 diabetes mellitus (T2DM) patients ≥10 and <18 years old as a single agent dosed once daily (QD) or in a fixed‐dose combination with metformin dosed twice daily (BID). We characterize canagliflozin pharmacokinetics in paediatric patients with T2DM, compare estimated individual and simulated ...
Nele Goeyvaerts, Per Olsson Gisleskog, Martine Neyens, Juan José Perez Ruixo, Saberi Rana Ali, Iolanda Cirillo, Oliver Ackaert   +6 more
wiley   +1 more source

Undoing of firing rate adaptation enables invariant population codes. [PDF]

Sci Adv
Brandão SC, Ramirez L, Züfle P, Walter AM, Silies M, Martelli C.   +5 more
europepmc   +1 more source

Relationship between continuous infusion meropenem PK/PD target attainment and C‐reactive protein dynamics in onco‐haematologic patients with febrile neutropenia

British Journal of Clinical Pharmacology, EarlyView.
Aim Meropenem is a second‐line antimicrobial agent in the treatment of febrile neutropenia in onco‐haematological patients. A population pharmacokinetic/pharmacodynamic (PK/PD) analysis for assessing the relationship between meropenem exposure and C‐reactive protein (C‐RP) over time was conducted.
Chun Liu, Pier Giorgio Cojutti, J. G. Coen van Hasselt, Michele Bartoletti, Maddalena Giannella, Pierluigi Zinzani, Pierluigi Viale, Federico Pea   +7 more
wiley   +1 more source

Low-vacuum scanning electron microscopy for informative three-dimensional imaging of cell/tissue architectures and biomedical target localization. [PDF]

Microscopy (Oxf)
Sawaguchi A.
europepmc   +1 more source

Pengaruh Pemberian Pravastatin terhadap Luas Glomerulus dan Diameter Arteriol pada Ginjal Tikus (Rattus norvegicus) Model Preeklampsia,

Preeklampsia merupakan gejala yang terjadi pada ibu hamil meliputi hipertensi, protein pada urine dan edema yang muncul setelah minggu ke 20 masa kehamilan hingga minggu ke 6 setelah melahirkan Preeklampsia sebagai penyakit yang berawal dari disfungsi
Oktaria, Riski Resa, dr. Kenty Wantri Anita, M.Kes, Sp.PA (K), Dr. dr. Bambang Rahardjo, Sp.OG(K)   +2 more
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