Results 171 to 180 of about 7,660 (199)

Post-Critical Period Transcriptional and Physiological Adaptations of Primary Sensory Cortex after Sensory Loss. [PDF]

J Neurosci
Iyer L, Johnson K, Collier S, Koretsky AP, Petrus E.   +4 more
europepmc   +1 more source

AMPA Receptors in NG2 Glia Differently Affect Signal Transduction in the Hippocampus and Cerebellum. [PDF]

Glia
Tascio D, Gebril N, Jabs R, Henneberger C, Steinhäuser C, Seifert G.   +5 more
europepmc   +1 more source

AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders

AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders
openaire   +1 more source

Synaptic homeostasis requires the membrane-proximal carboxy tail of GluA2 [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance AMPA-type glutamate receptors are known to play critical roles in both basal synaptic transmission and acute forms of plasticity, such as long-term potentiation and long-term depression, but less is known about their role in ...
Javier Díaz-Alonso, Roger Nicoll, Jonathan M Levy   +2 more
exaly   +4 more sources

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Hippocampus-specific deficiency in RNA editing of GluA2 in Alzheimer's disease

Neurobiology of Aging, 2014
Adenosine to inosine (A-to-I) RNA editing is a base recoding process within precursor messenger RNA, catalyzed by members of the adenosine deaminase acting on RNA (ADAR) family. A notable example occurs at the Q/R site of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptor subunit GluA2.
Michal Safran, Inna Gaisler-Salomon, Ninette Amariglio   +2 more
exaly   +3 more sources

Functional Roles of the Edited Isoform of GluA2 in GluA2-Containing AMPA Receptor Channels

Biochemistry, 2017
GluA2R is the edited isoform at the Q/R site of the AMPA receptor GluA2 subunit. In vivo, GluA2R assembles with other AMPA receptor subunits into a high-conductance, tetrameric complex. Here we study the functional role of GluA2R in the context of GluA1/2R and GluA2Q/2R heteromeric receptors, using whole-cell recording and a laser-pulse photolysis ...
Yan Han, Chi-Yen Lin, Li Niu
openaire   +2 more sources

Human Autoantibodies against the AMPA Receptor Subunit GluA2 Induce Receptor Reorganization and Memory Dysfunction

Neuron, 2018
AMPA receptors are essential for fast excitatorytransmission in the CNS. Autoantibodies to AMPAreceptors have been identified in humans withautoimmune encephalitis and severe defects ofhippocampal function.
Josep Dalmau, Joseph Classen, David Soto
exaly   +2 more sources

Tyrosine phosphorylation of the AMPA receptor subunit GluA2 gates homeostatic synaptic plasticity

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Throughout an organism’s life span, neural circuits mediate sensory and cognitive processing via synaptic plasticity, which involves synapse-specific Hebbian plasticity and network-level homeostatic plasticity. Synaptic strengthening and weakening are finely tuned by changes in postsynaptic α-amino-3-hydroxy-5-methyl-4 ...
Han L Tan, Adeline J H Yong, Richard L. Huganir   +2 more
exaly   +4 more sources

Lithium increases synaptic GluA2 in hippocampal neurons by elevating the δ-catenin protein [PDF]

Neuropharmacology, 2017
Lithium (Li+) is a drug widely employed for treating bipolar disorder, however the mechanism of action is not known. Here we study the effects of Li+ in cultured hippocampal neurons on a synaptic complex consisting of δ-catenin, a protein associated with cadherins whose mutation is linked to autism, and GRIP, an AMPA receptor (AMPAR) scaffolding ...
Edward B Ziff, Seonil Kim, Margaret E Rice   +2 more
exaly   +3 more sources