Results 1 to 10 of about 114,692 (269)

Striking the Balance: GLP-1/Glucagon Co-Agonism as a Treatment Strategy for Obesity

Frontiers in Endocrinology, 2021
Obesity and Type 2 diabetes represent global health challenges, and there is an unmet need for long-lasting and effective pharmacotherapies. Although long-acting glucagon-like peptide-1 (GLP-1) analogues are now in routine use for diabetes and are now ...
David C. D. Hope, Matthew L. Vincent, Tricia M. M. Tan   +2 more
doaj   +1 more source

Pathways of Glucagon Secretion and Trafficking in the Pancreatic Alpha Cell: Novel Pathways, Proteins, and Targets for Hyperglucagonemia

Frontiers in Endocrinology, 2021
Patients with diabetes mellitus exhibit hyperglucagonemia, or excess glucagon secretion, which may be the underlying cause of the hyperglycemia of diabetes.
Farzad Asadi, Farzad Asadi, Savita Dhanvantari, Savita Dhanvantari, Savita Dhanvantari, Savita Dhanvantari   +5 more
doaj   +1 more source

The liver-alpha-cell axis after a mixed meal and during weight loss in type 2 diabetes

Endocrine Connections, 2021
Objective: Glucagon and amino acids may be regulated in a feedback loop called the liver-alpha-cell axis with alanine or glutamine as suggested signal molecules.
Julia Otten, Andreas Stomby, Maria Waling, Elin Chorell, Mats Ryberg, Michael Svensson, Jens Juul Holst, Tommy Olsson   +7 more
doaj   +1 more source

Frequency and Causes of False-Positive Elevated Plasma Concentrations of Fasting Gut Hormones in a Specialist Neuroendocrine Tumor Center

Frontiers in Endocrinology, 2020
IntroductionIn the UK, the fasting plasma concentrations of a panel of gut hormones (comprising vasoactive intestinal peptide (VIP), gastrin, pancreatic polypeptide (PP), glucagon, somatostatin and chromogranin A) are measured to evaluate patients who ...
Olivia L. Butler, Monica M. Mekhael, Arslan Ahmed, Daniel J. Cuthbertson, Daniel J. Cuthbertson, D. Mark Pritchard, D. Mark Pritchard   +6 more
doaj   +1 more source

The entero-insular axis: a journey in the physiopathology of diabetes

Exploration of Medicine, 2020
Glycemic homeostasis is an essential mechanism for the proper working of an organism. However, balance in blood lipid and protein levels also plays an important role.
Roberta Malaguarnera, Alessandra Scamporrino, Agnese Filippello, Stefania Di Mauro, Alessandro Minardo, Francesco Purrello, Salvatore Piro   +6 more
doaj   +1 more source

The relationship between insulin and glucagon concentrations in non‐diabetic humans

Physiological Reports, 2022
Abnormal postprandial suppression of glucagon in Type 2 diabetes (T2DM) has been attributed to impaired insulin secretion. Prior work suggests that insulin and glucagon show an inverse coordinated relationship.
Marcello C. Laurenti, Praveer Arora, Chiara Dalla Man, James C. Andrews, Robert A. Rizza, Aleksey Matveyenko, Kent R. Bailey, Claudio Cobelli, Adrian Vella   +8 more
doaj   +1 more source

Somatostatin receptors in congenital hyperinsulinism: Biology to bedside

Frontiers in Endocrinology, 2022
Congenital hyperinsulinism (CHI), although a rare disease, is an important cause of severe hypoglycemia in early infancy and childhood, causing preventable morbidity and mortality.
Mirjam E. van Albada, Klaus Mohnike, Mark J. Dunne, Indi Banerjee, Stephen F. Betz   +4 more
doaj   +1 more source

13C MRS Studies of the Control of Hepatic Glycogen Metabolism at High Magnetic Fields

Frontiers in Physics, 2017
Introduction: Glycogen is the primary intracellular storage form of carbohydrates. In contrast to most tissues where stored glycogen can only supply the local tissue with energy, hepatic glycogen is mobilized and released into the blood to maintain ...
Corin O. Miller, Jin Cao, He Zhu, Li M. Chen, George Wilson, Richard Kennan, John C. Gore   +6 more
doaj   +1 more source

Effect of dipeptidyl peptidase-4 inhibitors on postprandial glucagon level in patients with type 2 diabetes mellitus: A systemic review and meta-analysis

Frontiers in Endocrinology, 2022
AimsHyperglucagonemia occurs in the pathogenesis of type 2 diabetes mellitus (T2DM). In this meta-analysis, we summarized the effects of DPP4 inhibitors on glucagon levels in patients with T2DM.Materials and methodsRandomized controlled trials (RCTs ...
Shangyu Chai, Ruya Zhang, Ye Zhang, Richard David Carr, Yiman Zheng, Swapnil Rajpathak, Linong Ji   +6 more
doaj   +1 more source

Low-Order Nonlinear Animal Model of Glucose Dynamics for a Bihormonal Intraperitoneal Artificial Pancreas [PDF]

IEEE Transactions on Biomedical Engineering 2021, 2020
Objective: The design of an Artificial Pancreas (AP) to regulate blood glucose levels requires reliable control methods. Model Predictive Control has emerged as a promising approach for glycemia control. However, model--based control methods require computationally simple and identifiable mathematical models that represent glucose dynamics accurately ...
arxiv   +1 more source