Results 1 to 10 of about 125,192 (190)
Glucagon Antibodies and an Immunoassay for Glucagon [PDF]
Journal of Clinical Investigation, 1961 Roger H. Unger +3 more
+7 more sources
Striking the Balance: GLP-1/Glucagon Co-Agonism as a Treatment Strategy for Obesity
Frontiers in Endocrinology, 2021 Obesity and Type 2 diabetes represent global health challenges, and there is an unmet need for long-lasting and effective pharmacotherapies. Although long-acting glucagon-like peptide-1 (GLP-1) analogues are now in routine use for diabetes and are now ...
David C. D. Hope +2 more
doaj +1 more source
Frontiers in Endocrinology, 2021 Patients with diabetes mellitus exhibit hyperglucagonemia, or excess glucagon secretion, which may be the underlying cause of the hyperglycemia of diabetes.
Farzad Asadi +5 more
doaj +1 more source
The liver-alpha-cell axis after a mixed meal and during weight loss in type 2 diabetes
Endocrine Connections, 2021 Objective: Glucagon and amino acids may be regulated in a feedback loop called the liver-alpha-cell axis with alanine or glutamine as suggested signal molecules.
Julia Otten +7 more
doaj +1 more source
Frontiers in Endocrinology, 2020 IntroductionIn the UK, the fasting plasma concentrations of a panel of gut hormones (comprising vasoactive intestinal peptide (VIP), gastrin, pancreatic polypeptide (PP), glucagon, somatostatin and chromogranin A) are measured to evaluate patients who ...
Olivia L. Butler +6 more
doaj +1 more source
The entero-insular axis: a journey in the physiopathology of diabetes
Exploration of Medicine, 2020 Glycemic homeostasis is an essential mechanism for the proper working of an organism. However, balance in blood lipid and protein levels also plays an important role.
Roberta Malaguarnera +6 more
doaj +1 more source
The relationship between insulin and glucagon concentrations in non‐diabetic humans
Physiological Reports, 2022 Abnormal postprandial suppression of glucagon in Type 2 diabetes (T2DM) has been attributed to impaired insulin secretion. Prior work suggests that insulin and glucagon show an inverse coordinated relationship.
Marcello C. Laurenti +8 more
doaj +1 more source
Glucagon Receptor Signaling and Glucagon Resistance [PDF]
International Journal of Molecular Sciences, 2019 Hundred years after the discovery of glucagon, its biology remains enigmatic. Accurate measurement of glucagon has been essential for uncovering its pathological hypersecretion that underlies various metabolic diseases including not only diabetes and liver diseases but also cancers (glucagonomas).
Lina Janah +8 more
openaire +5 more sources
Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells. [PDF]
, 2012 The peptide hormone Urocortin 3 (Ucn 3) is abundantly and exclusively expressed in mouse pancreatic beta cells where it regulates insulin secretion. Here we demonstrate that Ucn 3 first appears at embryonic day (E) 17.5 and, from approximately postnatal ...
Huising, Mark O +5 more
core +6 more sources
Somatostatin receptors in congenital hyperinsulinism: Biology to bedside
Frontiers in Endocrinology, 2022 Congenital hyperinsulinism (CHI), although a rare disease, is an important cause of severe hypoglycemia in early infancy and childhood, causing preventable morbidity and mortality.
Mirjam E. van Albada +4 more
doaj +1 more source