Results 1 to 10 of about 131,242 (269)
Striking the Balance: GLP-1/Glucagon Co-Agonism as a Treatment Strategy for Obesity
Frontiers in Endocrinology, 2021 Obesity and Type 2 diabetes represent global health challenges, and there is an unmet need for long-lasting and effective pharmacotherapies. Although long-acting glucagon-like peptide-1 (GLP-1) analogues are now in routine use for diabetes and are now ...
David C. D. Hope +2 more
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Frontiers in Endocrinology, 2021 Patients with diabetes mellitus exhibit hyperglucagonemia, or excess glucagon secretion, which may be the underlying cause of the hyperglycemia of diabetes.
Farzad Asadi +5 more
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Frontiers in Endocrinology, 2022 AimsHyperglucagonemia occurs in the pathogenesis of type 2 diabetes mellitus (T2DM). In this meta-analysis, we summarized the effects of DPP4 inhibitors on glucagon levels in patients with T2DM.Materials and methodsRandomized controlled trials (RCTs ...
Shangyu Chai +6 more
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The liver-alpha-cell axis after a mixed meal and during weight loss in type 2 diabetes
Endocrine Connections, 2021 Objective: Glucagon and amino acids may be regulated in a feedback loop called the liver-alpha-cell axis with alanine or glutamine as suggested signal molecules.
Julia Otten +7 more
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Frontiers in Endocrinology, 2020 IntroductionIn the UK, the fasting plasma concentrations of a panel of gut hormones (comprising vasoactive intestinal peptide (VIP), gastrin, pancreatic polypeptide (PP), glucagon, somatostatin and chromogranin A) are measured to evaluate patients who ...
Olivia L. Butler +6 more
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The relationship between insulin and glucagon concentrations in non‐diabetic humans
Physiological Reports, 2022 Abnormal postprandial suppression of glucagon in Type 2 diabetes (T2DM) has been attributed to impaired insulin secretion. Prior work suggests that insulin and glucagon show an inverse coordinated relationship.
Marcello C. Laurenti +8 more
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Scientia Pharmaceutica, 2022 Glucagon is a polypeptide hormone that serves as an essential therapeutic agent in the emergency treatment of hypoglycemia. Recently, the first generic glucagon for injection was approved. However, unlike its brand name counterpart, which is produced via
Zhongli Bao +3 more
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The entero-insular axis: a journey in the physiopathology of diabetes
Exploration of Medicine, 2020 Glycemic homeostasis is an essential mechanism for the proper working of an organism. However, balance in blood lipid and protein levels also plays an important role.
Roberta Malaguarnera +6 more
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Frontiers in Endocrinology, 2019 Glucagon, a key hormone for glucose homeostasis, can exert functional crosstalk with somatotropic axis via modification of IGF-I expression. However, its effect on IGF-I regulation is highly variable in different studies and the mechanisms involved are ...
Jin Bai +4 more
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Frontiers in Veterinary Science, 2023 Administering more than 10 times the therapeutic dose of insulin is extremely rare in diabetic dogs and is life threatening with hypoglycemia and seizures if not accompanied by appropriate treatment.
Jun-Hyeong Park +7 more
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