Results 1 to 10 of about 214,982 (356)

EFFECTS OF INSULIN, GLUCAGON, AND INSULIN/GLUCAGON INFUSIONS ON LIVER MORPHOLOGY AND CELL DIVISION AFTER COMPLETE PORTACAVAL SHUNT IN DOGS [PDF]

, 1976
Insulin, glucagon, and insulin/glucagon mixtures have been infused for four days into the left portal vein of dogs after portacaval shunt. In the left but not the right liver lobes, insulin alone reduced atrophy, preserved hepatocyte ultrastructure, and ...
Blackard, Bollman, Bucher, Child, Eck, Felig, Felig, Field, Fisher, Fisher, Hahn, Holley, Izzo, Leffert, Loud, Madison, Mann, Marchioro, Marchioro, Marchioro, Meyer, Popper, Reaven, Rous, Rubin, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Tchobroutsky, Warren, Wembren, Younger   +36 more
core   +2 more sources

Enhancing endogenous levels of GLP1 dampens acute olanzapine induced perturbations in lipid and glucose metabolism

Frontiers in Pharmacology, 2023
Olanzapine is a second-generation antipsychotic (SGA) used in the treatment of schizophrenia and several on- and off-label conditions. While effective in reducing psychoses, acute olanzapine treatment causes rapid hyperglycemia, insulin resistance, and ...
Kyle D. Medak, Alyssa J. Weber, Hesham Shamshoum, Greg L. McKie, Margaret K. Hahn, Margaret K. Hahn, Margaret K. Hahn, Margaret K. Hahn, Margaret K. Hahn, David C. Wright, David C. Wright, David C. Wright   +11 more
doaj   +1 more source

The VIP/VPAC1R Pathway Regulates Energy and Glucose Homeostasis by Modulating GLP-1, Glucagon, Leptin and PYY Levels in Mice

Biology, 2022
Vasoactive Intestinal Peptide binds with high affinity to VPAC1R and VPAC2R, thus regulating key physiologic functions. Previously, we documented in VIP−/− mice a leaner body phenotype and altered metabolic hormones.
Daniel Sanford, Leon Luong, John P. Vu, Suwan Oh, Arielle Gabalski, Michael Lewis, Joseph R. Pisegna, Patrizia Germano   +7 more
doaj   +1 more source

Postprandial dysfunction in fatty liver disease

Physiological Reports, 2023
Fatty liver disease has mainly been characterized under fasting conditions. However, as the liver is essential for postprandial homeostasis, identifying postprandial disturbances may be important.
Josephine Grandt, Anne‐Sofie H. Jensen, Mikkel P. Werge, Elias B. Rashu, Andreas Møller, Anders E. Junker, Lise Hobolth, Christian Mortensen, Christian D. Johansen, Mogens Vyberg, Reza Rafiolsadat Serizawa, Søren Møller, Lise Lotte Gluud, Nicolai J. Wewer Albrechtsen   +13 more
doaj   +1 more source

Comparison of the Purity and Impurity of Glucagon-for-Injection Products under Various Stability Conditions

Scientia Pharmaceutica, 2022
Glucagon is a polypeptide hormone that serves as an essential therapeutic agent in the emergency treatment of hypoglycemia. Recently, the first generic glucagon for injection was approved. However, unlike its brand name counterpart, which is produced via
Zhongli Bao, Ya-Chi Cheng, Mary Ziping Luo, Jack Yongfeng Zhang   +3 more
doaj   +1 more source

Frequency and Causes of False-Positive Elevated Plasma Concentrations of Fasting Gut Hormones in a Specialist Neuroendocrine Tumor Center

Frontiers in Endocrinology, 2020
IntroductionIn the UK, the fasting plasma concentrations of a panel of gut hormones (comprising vasoactive intestinal peptide (VIP), gastrin, pancreatic polypeptide (PP), glucagon, somatostatin and chromogranin A) are measured to evaluate patients who ...
Olivia L. Butler, Monica M. Mekhael, Arslan Ahmed, Daniel J. Cuthbertson, Daniel J. Cuthbertson, D. Mark Pritchard, D. Mark Pritchard   +6 more
doaj   +1 more source

Impact of the TCF7L2 genotype on risk of hypoglycaemia and glucagon secretion during hypoglycaemia

Endocrinology, Diabetes & Metabolism Case Reports, 2016
Introduction: In healthy carriers of the T allele of the transcription factor 7-like 2 (TCF7L2), fasting plasma glucagon concentrations are lower compared with those with the C allele.
Peter L Kristensen, Ulrik Pedersen-Bjergaard, Rikke Due-Andersen, Thomas Høi-Hansen, Lise Grimmeshave, Valeriya Lyssenko, Leif Groop, Jens J Holst, Allan A Vaag, Birger Thorsteinsson   +9 more
doaj   +1 more source

Insulin-like growth factor-1 is a negative modulator of glucagon secretion [PDF]

, 2017
Glucagon secretion involves a combination of paracrine, autocrine, hormonal, and autonomic neural mechanisms. Type 2 diabetes often presents impaired glucagon suppression by insulin and glucose.
Andreozzi, F, Di Fatta, C, Fuoco, A, Mancuso, E, Mannino, Gc, Sesti, G, Spiga, R   +6 more
core   +1 more source

Fasting and Glucagon Stimulate Gene Expression of Pyruvate Dehydrogenase Kinase 4 in Chickens

The Journal of Poultry Science, 2017
The excessive accumulation of body fat has become a serious problem in the broiler industry. However, the molecular mechanisms underlying the regulation of lipid metabolism-related genes in broiler chickens are not fully understood.
Kazuhisa Honda, Shoko Takagi, Kiyotaka Kurachi, Haruka Sugimoto, Takaoki Saneyasu, Hiroshi Kamisoyama   +5 more
doaj   +1 more source

Feeding frequency has diet-dependent effects on plasma hormone concentrations but does not affect oocyte quality in dairy heifers fed fibre- or starch-based diets

Animal, 2008
The post-fertilisation developmental capacity of bovine oocytes recovered by ultrasound guided transvaginal follicular aspiration (ovum pick-up, OPU) is influenced by diet-induced changes in hormone and metabolite concentrations.
J.A. Rooke, A. Ainslie, R.G. Watt, F.M. Alink, T.G. McEvoy, K.D. Sinclair, P.C. Garnsworthy, R. Webb   +7 more
doaj   +1 more source