Results 241 to 250 of about 28,560,894 (288)

Influence of glucagon-like peptide 2 on energy homeostasis

Peptides, 2016
Glucagon like peptide-2 (GLP-2) is a gastrointestinal hormone released from enteroendocrine L-type cells together with glucagon like peptide-1 in response to dietary nutrients. GLP-2 acts through a specific receptor, the GLP-2 receptor, mainly located in the gut and in the brain.
Sara Baldassano, Antonella Amato, Flavia Mulè   +2 more
openaire   +2 more sources

Structural Determinants for Activity of Glucagon-like Peptide-2

Biochemistry, 2000
Glucagon-like peptide-2 (GLP-2) is a 33 amino acid gastrointestinal hormone that regulates epithelial growth in the intestine. Dipeptidylpeptidase IV cleaves GLP-2 at the position 2 alanine, resulting in the inactivation of peptide activity. To understand the structural basis for GLP-2 action, we studied receptor binding and activation for 56 GLP-2 ...
M P, DaCambra, B, Yusta, M, Sumner-Smith, A, Crivici, D J, Drucker, P L, Brubaker   +5 more
openaire   +2 more sources

The “cryptic” mechanism of action of glucagon-like peptide-2

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2011
Glucagon-like peptide-2 (GLP-2) is a peptide hormone with multiple beneficial effects on the intestine, including expansion of the mucosal surface area through stimulation of crypt cell proliferation, as well as enhancement of nutrient digestion and absorption.
Katherine J, Rowland, Patricia L, Brubaker   +1 more
openaire   +2 more sources

Life in the crypt: A role for glucagon-like peptide-2?

Molecular and Cellular Endocrinology, 2008
The epithelial layer of the intestinal tract serves as a model to study the mechanisms regulating tissue renewal. Central to this process is the intestinal stem cell and, thus, both the intrinsic and extrinsic factors that modulate the function of these cells must be understood.
Katherine J, Rowland, Patricia L, Brubaker   +1 more
openaire   +2 more sources

Glucagon-like peptide 2 function in domestic animals

Domestic Animal Endocrinology, 2003
Glucagon-like peptide 2 (GLP-2) is a member of family of peptides derived from the proglucagon gene expressed in the intestines, pancreas and brain. Tissue-specific posttranslational processing of proglucagon leads to GLP-2 and GLP-1 secretion from the intestine and glucagon secretion from the pancreas.
D G, Burrin, B, Stoll, X, Guan
openaire   +2 more sources

Glucagon like peptide-2 and neoplasia; a systematic review

Expert Review of Gastroenterology & Hepatology, 2017
Glucagon like peptide-2 is synthesized from enteroendocrine L cells primarily located in the ileum and large intestine. GLP-2 stimulates crypt cell proliferation, increases intestinal blood flow, enhances gut barrier function, induces mucosal healing, and exerts an anti-apoptotic effect.
Ring, Linea Landgrebe, Nerup, Nikolaj, Jeppesen, Palle Bekker, Svendsen, Lars Bo, Achiam, Michael Patrick   +4 more
openaire   +3 more sources

Glucagon and Glucagon-Like Peptides 1 and 2

2009
The glucagon gene is expressed not only in the alpha cells of the pancreatic islets but also in the endocrine cells of the intestinal epithelium (so-called L-cells), and in certain neurons of the brain stem. Whereas in the pancreas, glucagon, the hyperglycaemic hormone, is cleaved out of the 160 amino acid precursor, proglucagon, leaving behind ...
openaire   +3 more sources

A kinetic study of glucagon-like peptide-1 and glucagon-like peptide-2 truncation by dipeptidyl peptidase IV, in vitro

Biochemical Pharmacology, 2002
In vivo inactivation of glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) was found to be associated with the proteolytic removal of their N-terminal dipeptide by the ectopeptidase dipeptidyl peptidase IV (DPP IV). Previous studies suggested that the in vivo metabolism of GLP-1 is much faster than that of GLP-2.
Lambeir, Anne-Marie, Proost, Paul, Scharpe, Simon, De Meester, Ingrid   +3 more
openaire   +3 more sources

Clinical endocrinology and metabolism. Glucagon-like peptide-1 and glucagon-like peptide-2.

Best practice & research. Clinical endocrinology & metabolism, 2005
The glucagon-like peptides (glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2)) are released from enteroendocrine cells in response to nutrient ingestion. GLP-1 enhances glucose-stimulated insulin secretion and inhibits glucagon secretion, gastric emptying and feeding. GLP-1 also has proliferative, neogenic and antiapoptotic effects on
Laurie L, Baggio, Daniel J, Drucker
openaire   +1 more source

Enterotrophic effects of glucagon-like peptide 2 are enhanced by neurotensin

Journal of Gastrointestinal Surgery, 1998
Combination therapy with enterotrophic agents may be useful in patients with the short bowel syndrome. The gut hormones neurotensin (NT) and glucagon-like peptide 2 (GLP-2) are potent enterotrophic factors when administered alone; however, their combined effects are not known.
D A, Litvak, B M, Evers, M R, Hellmich, C M, Townsend   +3 more
openaire   +2 more sources