Results 261 to 270 of about 119,167 (297)

Glucagon-like peptide 2 inhibits ghrelin secretion in humans

Regulatory Peptides, 2006
The growth hormone secretagogue receptor ligand ghrelin is known to play a pivotal role in the central nervous control of energy homeostasis. Circulating ghrelin levels are high under fasting conditions and decline after meal ingestion, but the mechanisms underlying the postprandial drop in ghrelin levels are poorly understood.
Banasch, Matthias, Bulut, Kerem, Hagemann, Dirk, Schrader, Henning, Holst, Jens Juul, Schmidt, Wolfgang E, Meier, Juris J   +6 more
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Glucagon-Like Peptide 2 (GLP-2), An Intestinotrophic Mediator

Current Protein & Peptide Science, 2004
Glucagon-like peptide 2 (GLP-2) is a newly discovered gastrointestinal peptide with 33% sequence homology to glucagon. GLP-2 has attracted interest because of its potent intestinotrophic endocrine/paracrine actions. The peptide, consisting of 33-amino-acid, results from expression of the glucagon gene in the enteroendocrine L-cells of the intestinal ...
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Glucagon-like peptide-1 analogues for type 2 diabetes

BMJ, 2011
#### Case scenario A 58 year old woman attends a diabetes clinic with type 2 diabetes of seven years’ duration and no history of macrovascular disease. She is obese (body mass index 37), but says she eats a healthy diet and describes this. Her blood pressure is 134/78 mm Hg, and she has microalbuminuria, but normal renal function and a lipid profile ...
John P H, Wilding, Kevin, Hardy
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The dimerization of glucagon‐like peptide‐2 MIMETIBODY™ is linked to leucine‐17 in the glucagon‐like peptide‐2 region

Journal of Molecular Recognition, 2012
Glucagon‐like peptide‐2 (GLP‐2) is a member of the glucagon multigene family that is produced by intestinal enteroendocrine cells in response to food intake. GLP‐2 stimulates growth of the intestinal epithelium, enhances its barrier functions, and increases nutrient uptake.
Audrey E, Baker, Sarah, Sague, Tami L R, Grygiel, Albert, Schmidt, Alison, Rogers, Haiyan, Jiang, Marian, Kruszynski, Tom, Nesspor   +7 more
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Clinical endocrinology and metabolism. Glucagon-like peptide-1 and glucagon-like peptide-2.

Best practice & research. Clinical endocrinology & metabolism, 2005
The glucagon-like peptides (glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2)) are released from enteroendocrine cells in response to nutrient ingestion. GLP-1 enhances glucose-stimulated insulin secretion and inhibits glucagon secretion, gastric emptying and feeding. GLP-1 also has proliferative, neogenic and antiapoptotic effects on
Laurie L, Baggio, Daniel J, Drucker
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Glucagon and Glucagon-Like Peptides 1 and 2

2009
The glucagon gene is expressed not only in the alpha cells of the pancreatic islets but also in the endocrine cells of the intestinal epithelium (so-called L-cells), and in certain neurons of the brain stem. Whereas in the pancreas, glucagon, the hyperglycaemic hormone, is cleaved out of the 160 amino acid precursor, proglucagon, leaving behind ...
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Glucagon-like peptide-2 relaxes mouse stomach through vasoactive intestinal peptide release

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2009
Glucagon-like peptide-2 (GLP-2) influences different aspects of the gastrointestinal function, including epithelial growth, digestion, absorption, motility, and blood flow. Intraluminal pressure from isolated mouse stomach was recorded to investigate whether GLP-2 affects gastric tone and to analyze its mechanism of action.
AMATO, Antonella, BALDASSANO, Sara, SERIO, Rosa Maria, MULE', Flavia   +3 more
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Glucagon‐like peptide‐2 inhibits antral emptying in man, but is not as potent as glucagon‐like peptide‐1

Scandinavian Journal of Gastroenterology, 2004
GLP-1 (glucagon-like peptide-1) and GLP-2 (glucagon-like peptide-2) are released in equimolar amounts in response to meal ingestion. GLP-1 inhibits gastric emptying and reduces postprandial gastric and exocrine pancreatic secretion and may play a physiological regulatory role in controlling appetite and energy intake in humans.
Nagell, C F, Wettergren, A, Pedersen, J F, Mortensen, D, Holst, Jens Juul   +4 more
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Glucagon-like peptide-2: divergent signaling pathways.

The Journal of surgical research, 2004
Glucagon-like peptide 2 (GLP-2) is an endogenous hormone with potent and specific intestinotrophic activity in vivo and in vitro. The aim of this study was to define the initial signal transduction mechanisms mediating the proliferative actions of GLP-2 on intestinal epithelial cells.The proliferative actions of GLP-2 on the human Caco-2 cell line were
Flavio G, Rocha, K Robert, Shen, Jasleen, Jasleen, Ali, Tavakkolizadeh, Michael J, Zinner, Edward E, Whang, Stanley W, Ashley   +6 more
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Glucagon-like peptide-2

2021
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