Results 1 to 10 of about 42,521 (302)

A novel glucagon-related peptide (GCRP) and its receptor GCRPR account for coevolution of their family members in vertebrates. [PDF]

PLoS ONE, 2013
The glucagon (GCG) peptide family consists of GCG, glucagon-like peptide 1 (GLP1), and GLP2, which are derived from a common GCG precursor, and the glucose-dependent insulinotropic polypeptide (GIP).
Cho Rong Park, Mi Jin Moon, Sumi Park, Dong-Kyu Kim, Eun Bee Cho, Robert Peter Millar, Jong-Ik Hwang, Jae Young Seong   +7 more
doaj   +1 more source

Radiolabelled peptides for oncological diagnosis [PDF]

, 2012
Radiolabelled receptor-binding peptides targeting receptors (over)expressed on tumour cells are widely under investigation for tumour diagnosis and therapy.
Peter Laverman, Jane K. Sosabowski, Otto C. Boerman, Wim J. G. Oyen   +3 more
core   +1 more source

Intra-islet glucagon-like peptide 1 [PDF]

Journal of Diabetes and its Complications, 2016
Glucagon-like peptide-1 (GLP-1) is originally identified in the gut as an incretin hormone, and it is potent in stimulating insulin secretion in the pancreas. However, increasing evidence suggests that GLP-1 is also produced locally within pancreatic islets.
Genevieve E. Fava, Emily W. Dong, Hongju Wu   +2 more
openaire   +2 more sources

The Role of Gasotransmitters in Gut Peptide Actions

Frontiers in Pharmacology, 2021
Although gasotransmitters nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) receive a bad connotation; in low concentrations these play a major governing role in local and systemic blood flow, stomach acid release, smooth muscles ...
Wout Verbeure, Harry van Goor, Hideki Mori, André P. van Beek, Jan Tack, Peter R. van Dijk   +5 more
doaj   +1 more source

Structural changes in intestinal enteroendocrine cells after ileal interposition in normal rats [PDF]

, 2011
INTRODUCTION: No therapeutic approach has significantly impacted the progression of diabetes. As early improvement of glicaemic control is observed after bariatric surgeries, there is currently a search for surgical procedures that can promote euglycemia
Aparecida Hirata, Bianca Marigliani, Gilmara Aguiar-Yamaguchi, Gustavo Miguel, José-Francisco Borborema, João-Luiz Azevedo, João-Luiz Azevedo, João-Luiz Azevedo, Karina Neves, Linda Bernardes, Lucas Leal, Marcelo Carlini, Maria Alves, Otavio Azevedo, Paolo Lourenco, Rudy Rocha, Wellington Cardia   +16 more
core   +2 more sources

Acute activation of GLP-1-expressing neurons promotes glucose homeostasis and insulin sensitivity

Molecular Metabolism, 2017
Objective: Glucagon-like peptides are co-released from enteroendocrine L cells in the gut and preproglucagon (PPG) neurons in the brainstem. PPG-derived GLP-1/2 are probably key neuroendocrine signals for the control of energy balance and glucose ...
Xuemei Shi, Shaji Chacko, Feng Li, Depei Li, Douglas Burrin, Lawrence Chan, Xinfu Guan   +6 more
doaj   +1 more source

New Bioactive Peptides Identified from a Tilapia Byproduct Hydrolysate Exerting Effects on DPP-IV Activity and Intestinal Hormones Regulation after Canine Gastrointestinal Simulated Digestion

Molecules, 2020
Like their owners, dogs and cats are more and more affected by overweight and obesity-related problems and interest in functional pet foods is growing sharply.
Sandy Theysgeur, Benoit Cudennec, Barbara Deracinois, Claire Perrin, Isabelle Guiller, Anne Lepoudère, Christophe Flahaut, Rozenn Ravallec   +7 more
doaj   +1 more source

Pancreatic exocrine insufficiency after bariatric surgery [PDF]

, 2017
Morbid obesity is a lifelong disease, and all patients require complementary follow-up including nutritional surveillance by a multidisciplinary team after bariatric procedures.
Arnelo, Urban, Haas, Stephan L., Löhr, J. -Matthias, Martin, Lena, Rutkowski, Wiktor, Thorell, Anders, Valente, Roberto, Vujasinovic, Miroslav   +7 more
core   +1 more source

Role of Melatonin, Galanin, and RFamide Neuropeptides QRFP26 and QRFP43 in the Neuroendocrine Control of Pancreatic β-Cell Function

Frontiers in Endocrinology, 2017
Glucose homeostasis is finely regulated by a number of hormones and peptides released mainly from the brain, gastrointestinal tract, and muscle, regulating pancreatic secretion through cellular receptors and their signal transduction cascades.
Iacopo Gesmundo, Tania Villanova, Dana Banfi, Giacomo Gamba, Riccarda Granata   +4 more
doaj   +1 more source

Recombinant Peptide Production Platform Coupled with Site-Specific Albumin Conjugation Enables a Convenient Production of Long-Acting Therapeutic Peptide

Pharmaceutics, 2020
The number of therapeutic peptides for human treatment is growing rapidly. However, their development faces two major issues: the poor yield of large peptides from conventional solid-phase synthesis, and the intrinsically short serum half-life of ...
Mijeong Bak, Junyong Park, Kiyoon Min, Jinhwan Cho, Jihyoun Seong, Young S. Hahn, Giyoong Tae, Inchan Kwon   +7 more
doaj   +1 more source