Results 41 to 50 of about 42,521 (302)

G-protein-coupled receptors for free fatty acids: nutritional and therapeutic targets [PDF]

, 2014
It is becoming evident that nutrients and metabolic intermediates derived from such nutrients regulate cellular function by activating a number of cell-surface G-protein coupled receptors (GPCRs).
Brian D. Hudson, Graeme Milligan, Hannah Murdoch, Hoveyda, Ma, Saniere, Trond Ulven   +6 more
core   +2 more sources

Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders

Frontiers in Neuroscience, 2014
Peptides synthesized in endocrine cells in the gastrointestinal tract and neurons are traditionally considered regulators of metabolism, energy intake, and appetite. However, recent work has demonstrated that many of these peptides act on corticostriatal-
Chelsea A Vadnie, Jun Hyun ePark, Noha eAbdel Gawad, Ada Man Choi eHo, David J Hinton, Doo-Sup eChoi   +5 more
doaj   +1 more source

The associations of gut microbiota, endocrine system and bone metabolism

Frontiers in Microbiology, 2023
Gut microbiota is of great importance in human health, and its roles in the maintenance of skeletal homeostasis have long been recognized as the “gut-bone axis.” Recent evidence has indicated intercorrelations between gut microbiota, endocrine system and
Ye Tu, Ye Tu, Xinyi Kuang, Xinyi Kuang, Ling Zhang, Xin Xu, Xin Xu   +6 more
doaj   +1 more source

Glucagon-Like Peptide-1

JACC: Basic to Translational Science, 2016
Glucagon-like peptide-1-(7-36) amide (GLP-1) is a human incretin hormone responsible for the release of insulin in response to food. Pre-clinical and human physiological studies have demonstrated cardioprotection from ischemia-reperfusion injury. It can reduce infarct size, ischemic left ventricular dysfunction, and myocardial stunning.
Joel P. Giblett, BM, BSc, Sophie J. Clarke, BSc, David P. Dutka, MD, Stephen P. Hoole, MA, DM   +3 more
openaire   +3 more sources

Mice Deficient in Proglucagon-Derived Peptides Exhibit Glucose Intolerance on a High-Fat Diet but Are Resistant to Obesity. [PDF]

PLoS ONE, 2015
Homozygous glucagon-GFP knock-in mice (Gcggfp/gfp) lack proglucagon derived-peptides including glucagon and GLP-1, and are normoglycemic. We have previously shown that Gcggfp/gfp show improved glucose tolerance with enhanced insulin secretion.
Yusuke Takagi, Keita Kinoshita, Nobuaki Ozaki, Yusuke Seino, Yoshiharu Murata, Yoshiharu Oshida, Yoshitaka Hayashi   +6 more
doaj   +1 more source

Distinct Identity of GLP-1R, GLP-2R, and GIPR Expressing Cells and Signaling Circuits Within the Gastrointestinal Tract

Frontiers in Cell and Developmental Biology, 2021
Enteroendocrine cells directly integrate signals of nutrient content within the gut lumen with distant hormonal responses and nutrient disposal via the production and secretion of peptides, including glucose-dependent insulinotropic polypeptide (GIP ...
Nadya M. Morrow, Nadya M. Morrow, Antonio A. Hanson, Antonio A. Hanson, Erin E. Mulvihill, Erin E. Mulvihill, Erin E. Mulvihill, Erin E. Mulvihill   +7 more
doaj   +1 more source

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

Endomicroscopic and transcriptomic analysis of impaired barrier function and malabsorption in environmental enteropathy [PDF]

, 2016
Introduction: Environmental enteropathy (EE) is associated with growth failure, micronutrient malabsorption and impaired responses to oral vaccines.
A Prendergast, A Veitch, AC Illing, AJ Prendergast, Alastair Watson, AM Marchiando, AM Marchiando, AM Marchiando, AR Tenorio, B Sandström, Beatrice Amadi, D Gunzel, DI Campbell, E Salazar-Lindo, Ellen Besa, EM Vestergaard, G Marchetti, GC Cook, GT Keusch, J Brenchley, J Vesterbacka, J Zulu, James Lees, JH Humphrey, JM Williams, John Louis-Auguste, JR Turner, Kanekwa Zyambo, L Aamann, L Bremholm, LG Lim, LS Valberg, M Kosek, MH Wojcik, MJ Manary, MM Levine, MS Wapenaar, N Kimer, P Bellot, P Janssen, P Kelly, P Kelly, P Kelly, Paul Kelly, PB Jeppesen, Q Xiao, R Kiesslich, R Kiesslich, RL Guerrant, Rose Soko, Rosemary Banda, S Baldassano, S Tarazona, T Mizuno, Themba Banda, U Trautvetter, V Giorgio, VF Zevallos, W Dhaliwal, WA Petri, William A. Petri, Y Guan   +61 more
core   +5 more sources

Proglucagon peptide secretion profiles in type 2 diabetes before and after bariatric surgery: 1-year prospective study

BMJ Open Diabetes Research & Care, 2020
IntroductionHyperglucagonemia is a key pathophysiological driver of type 2 diabetes. Although Roux-en-Y gastric bypass (RYGB) is a highly effective treatment for diabetes, it is presently unclear how surgery alters glucagon physiology.
Kleopatra Alexiadou, Joyceline Cuenco, Nicolai Jacob Wewer Albrechtsen, Ibiyemi Ilesanmi, Anna Kamocka, George Tharakan, Preeshila Behary, Paul R Bech, Ahmed R Ahmed, Sanjay Purkayastha, Robert Wheller, Matthieu Fleuret, Stephen R Bloom, Bernard Khoo, Tricia M-M Tan   +14 more
doaj   +1 more source

[Gly²]-GLP-2, But Not Glucagon or [D-Ala²]-GLP-1, Controls Collagen Crosslinking in Murine Osteoblast Cultures

Frontiers in Endocrinology, 2021
Bone tissue is organized at the molecular level to resist fracture with the minimum of bone material. This implies that several modifications of the extracellular matrix, including enzymatic collagen crosslinking, take place.
Aleksandra Mieczkowska, Beatrice Bouvard, Beatrice Bouvard, Erick Legrand, Erick Legrand, Guillaume Mabilleau, Guillaume Mabilleau   +6 more
doaj   +1 more source