Results 171 to 180 of about 42,521 (302)

Retatrutide Shows Multiple Metabolic Benefits in Diet‐Induced Obese MASH Mouse and Hamster Models

Obesity, EarlyView.
ABSTRACT Objective/Methods Our aim was to evaluate the efficacy of the triple glucagon, GIP, and GLP‐1 receptor agonist retatrutide in diet‐induced obese MASH mouse and hamster models, two preclinical models that we routinely use for assessing new therapies targeting obesity.
François Briand, Camille Le Cudennec, Estelle Grasset, Natalia Breyner, Claire Bigot, Pierre Dillard, Thierry Sulpice   +6 more
wiley   +1 more source

Design and biological evaluation of triagonist GLP-1R/GCGR/GIPR peptides as potential therapeutic agents for diabetes and obesity. [PDF]

RSC Med Chem
Kalinowska I, Gawalska A, Kasprzycka P, Stępniewski M, Rózga P, Pałka A, Shubin A, Bukato K, Gałązka M, Burchard E, Zielińska-Świder P, Jaworski A, Feder M.   +12 more
europepmc   +1 more source

Twenty‐Four Month Outcomes From a Real‐World Telehealth Obesity Treatment Clinic Using Obesity Medications

Obesity, EarlyView.
ABSTRACT Objective Antiobesity medications (AOMs) are indicated for long‐term use; however, evidence of their real‐world long‐term efficacy is limited. This study describes clinical outcomes from 18‐ and 24‐month use of AOMs in a telemedicine weight management clinic.
Kathleen R. Ruddiman, Young‐Rock Hong, Jamy Ard, Rebecca Jones, Adam Medcalf, Gary D. Foster, Jamil Alkhaddo, Michelle Cardel   +7 more
wiley   +1 more source

The use of GLP-1 receptor agonists and co-agonists in adults without diabetes: a systematic review and network meta-analysis protocol. [PDF]

Syst Rev
Moiz A, Reynier P, Tsoukas MA, Yu OH, Peters TM, Eisenberg MJ, Filion KB.   +6 more
europepmc   +1 more source

Weight Loss With GLP‐1 Agonists in Nondiabetic Adults: Systematic Review and Network Meta‐Analysis

Obesity, EarlyView.
ABSTRACT Objective Two glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) (semaglutide and liraglutide) and one dual agonist (tirzepatide) are FDA‐approved for weight loss in adults with obesity without type 2 diabetes mellitus. This systematic review and network meta‐analysis aims to compare the efficacy of these agents against each other.
Michael Lim, Pooja Gokhale, Akwasi Akosah, Lorenzo Villa‐Zapata   +3 more
wiley   +1 more source

Crystallization and 1.6 Å resolution crystal structure of an acylated GLP-1/GIP analogue peptide. [PDF]

Acta Crystallogr F Struct Biol Commun
Mitchell HM, Nocek B, Guinn EJ, Heng JYY.   +3 more
europepmc   +1 more source

Novel insights into the regulation of postprandial lipemia by glucagon-like peptides: significance for diabetes. [PDF]

Diabetes, 2013
Watts GF, Chan DC.
europepmc   +1 more source

Evaluating the Evolving Real‐World Adverse Events of GLP‐1RAs Using FDA Adverse Event Reporting System (FAERS)

Obesity, EarlyView.
Web portal for interrogating Adverse Events of GLP‐1 RA in diabetes vs weight control/obesity. ABSTRACT Objective This study aimed to assess the spectrum and frequency of adverse events (AEs) linked to glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) using the US FDA Adverse Event Reporting System (FAERS).
David Stone, Mary Playdon, Stephen D. Hursting, Aik Choon Tan   +3 more
wiley   +1 more source

Liver fibrosis and type 2 diabetes modulate postprandial incretin and glucagon responses in fatty liver disease. [PDF]

J Physiol Biochem
Astiarraga B, Rodriguez-Castellano A, Ceperuelo-Mallafré V, Marsal-Beltran A, Osuna-Prieto FJ, Vilanova N, Gracia-Sancho J, Quer JC, Megía A, Balteiro AP, Vendrell J, Fernández-Veledo S.   +11 more
europepmc   +1 more source

Parental Communication With Children Around Obesity Management Medications, Weight Loss, and Health Behavior Change

Obesity, EarlyView.
ABSTRACT Objective This study aimed to describe parental communication with children around obesity management medications (OMMs) and child, parent, and family factors associated with communication. Methods Parents (N = 211; 80% mothers; 89% White) prescribed OMMs at a medical center participated in a survey about communication with children about OMM ...
Keeley J. Pratt, Selena Gonzlez‐Jordan, Sabrena F. Noria, Joseph A. Skelton   +3 more
wiley   +1 more source