Results 71 to 80 of about 42,175 (206)

Structure and functional motifs of GCR1, the only plant protein with a GPCR fold? [PDF]

, 2013
Whether GPCRs exist in plants is a fundamental biological question. Interest in deorphanizing new G protein coupled receptors (GPCRs), arises because of their importance in signaling.
Abdalla, Nuradin Y, Bailey, Gregory R, Jordon, Sian R D, Reeves, Philip J, Reynolds, Christopher A, Taddese, Bruck, Upton, Graham J G   +6 more
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PCSK1 Mutations and Human Endocrinopathies: From Obesity to Gastrointestinal Disorders. [PDF]

, 2016
Prohormone convertase 1/3, encoded by the PCSK1 gene, is a serine endoprotease that is involved in the processing of a variety of proneuropeptides and prohormones. Humans who are homozygous or compound heterozygous for loss-of-function mutations in PCSK1

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Clinical application of 99mTc‐labeled peptides for tumor imaging: Current status and future directions

iRADIOLOGY
Targeting receptors overexpressed on cancer cells with radiolabeled peptides has become a crucial aspect of molecular imaging in oncology. Small peptides offer favorable characteristics for tumor targeting with minimal side effects and toxicity owing to ...
Jiyun Shi, Shuang Liu
doaj   +1 more source

Dysregulation of Metabolic Peptides in the Gut–Brain Axis Promotes Hyperinsulinemia, Obesity, and Neurodegeneration

Biomedicines
Metabolic peptides can influence metabolic processes and contribute to both inflammatory and/or anti-inflammatory responses. Studies have shown that there are thousands of metabolic peptides, made up of short chains of amino acids, that the human body ...
Camille Green, Vandana Zaman, Kayce Blumenstock, Narendra L. Banik, Azizul Haque   +4 more
doaj   +1 more source

Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma

EBioMedicine, 2016
Low-abundance regulatory peptides, including metabolically important gut hormones, have shown promising therapeutic potential. Here, we present a streamlined mass spectrometry-based platform for identifying and characterizing low-abundance regulatory ...
Nicolai J. Wewer Albrechtsen, Daniel Hornburg, Reidar Albrechtsen, Berit Svendsen, Signe Toräng, Sara L. Jepsen, Rune E. Kuhre, Marie Hansen, Charlotte Janus, Andrea Floyd, Asger Lund, Tina Vilsbøll, Filip K. Knop, Henrik Vestergaard, Carolyn F. Deacon, Felix Meissner, Matthias Mann, Jens J. Holst, Bolette Hartmann   +18 more
doaj   +1 more source

Review article: a comparison of glucagon-like peptides 1 and 2. [PDF]

, 2013
BACKGROUND: Recent advancements in understanding the roles and functions of glucagon-like peptide 1 (GLP-1) and 2 (GLP-2) have provided a basis for targeting these peptides in therapeutic strategies.
Amato, Amato, Amato, Amin, Andrews, Andrews, Angelone, Anini, Anvari, Au, Baggio, Baggio, Bahrami, Baldassano, Baldassano, Bengi, Benjamin, Bjerknes, Blomgren, Booth, Bose, Boushey, Boushey, Bremholm, Brubaker, Brubaker, Brubaker, Brubaker, Buchman, Bucinskaite, Bullock, Buse, Caddy, Cameron, Cameron, Campos, Cani, Chance, Cheeseman, Cinci, Cummings, Daniel, Deacon, Deacon, Delgado-Aros, Drucker, Drucker, Drucker, Drucker, Drucker, Drucker, Drucker, Drucker, Dube, Dube, Dube, Dunphy, Estall, Farilla, Fehmann, Flint, Garber, Giralt, Goke, Guan, Guan, Gutzwiller, Gutzwiller, Hadjiyanni, Hansen, Hansen, Hargrove, Hartmann, Herrmann, Holst, Holst, Hornby, Hsieh, Hui, Iakoubov, Imeryuz, Iwai, Jeppesen, Jeppesen, Jeppesen, Jeppesen, Jeppesen, Johansen, Kato, Kendall, Kieffer, Kim, Kim, Knauf, Knudsen, Koehler, Koehler, Koopmann, Koopmann, Kunkel, Leen, Li, Lim, Linnebjerg, Liu, Liu, Lovshin, Lovshin, Lovshin, Madsbad, Marre, Martin, Martin, McDonagh, Meier, Meier, Miki, Moretto, Munroe, Nagell, Nakagawa, Naslund, Naslund, Nauck, Nelson, Nelson, Nielsen, Nikolaidis, Nystrom, Orskov, Orskov, Orskov, Orskov, Orskov, Orskov, Parks, Peters, Petersen, Petersen, Petersen, Pinelli, Portha, Reimann, Reimann, Roberge, Rocca, Rotondo, Rouille, Rowland, Rowland, Ruiz-Grande, Schirra, Schmidt, Schmidt, Schwartz, Scott, Shin, Sigalet, Sigalet, Sinclair, Skarbaliene, Sorensen, Stephens, Sturis, Tanaka, Tang-Christensen, Tang-Christensen, Tavares, Tee, Thong, Thulesen, Thulesen, Tolessa, Tolessa, Tornehave, Trivedi, Tsai, Tsai, Ugleholdt, Velazquez, Velazquez, Verdich, Voss, Vrang, Wallis, Wallis, Washizawa, Wettergren, Wettergren, Wheeler, Wideman, Wishart, Wojdemann, Wojdemann, Xiao, Xiao, Xu, Yamamoto, Yamazaki, Yusta, Yusta, Zhu, Zinman   +202 more
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Conceptualization of a Parasympathetic Endocrine System

Frontiers in Neuroscience, 2019
We here propose a parasympathetic endocrine system (PES) comprised of circulating peptides released from secretory cells in the gut, significantly modulated by vagal projections from the dorsal motor nucleus of the vagus (DMV).
Jonathan Gorky, James Schwaber
doaj   +1 more source

Glucagon-like peptide-1 and its class B G protein-coupled receptors: A long march to therapeutic successes [PDF]

, 2016
Theglucagon-likepeptide (GLP)-1receptor (GLP-1R) is a class B G protein-coupled receptor (GPCR) that mediates the action of GLP-1, a peptide hormone secretedfromthreemajor tissues inhumans,enteroendocrine L cells in the distal intestine, a cells in the ...
Adelhorst, Alastair J. H. Brown, Andersen, Avatapalle, Belin, Brown, Caihong Zhou, Chris de Graaf, Dan Donnelly, Davis, Dehua Yang, Denise Wootten, Denker, Dods, Drucker, Elahi, Ferguson, Gallwitz, Goodman, Green, Grynkiewicz, Gustavson, Göke, Hendrick, Heppner, Hjorth, Holst, Holst, Huang, Jendle, Jesper Lau, Jiayu Liao, Jiejie Deng, Jung-Mo Ahn, La Barre, Laurence J. Miller, Li, Locatelli-Hoops, Lund, Madeleine M. Fletcher, Ming-Wei Wang, Mojsov, Mojsov, Nauck, Nauck, Orskov, Orskov, Patrick M. Sexton, Pocai, Prentki, Rhodes, RICHARD DEQUAN YE, Sancho, Shiue, Steensgaard, Tang-Christensen, Tibaduiza, Tomkin, Unson, Wettergren, Widmann, Wild, Willard, Zunz   +63 more
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Effectiveness and safety of once-weekly semaglutide: findings from the SEMACOL-REAL retrospective multicentric observational study in Colombia

Frontiers in Endocrinology
IntroductionDiabetes stands as one of the leading causes of death worldwide. Glucagon-like peptide-1 receptor agonists rank among the most effective medications for lowering blood glucose and body weight, as well as reducing cardiovascular risk in ...
Daisy C. Buenaventura-Collazos, Andrés F. García-Ramos, Carlos M. Balcázar-Valencia, Carolina Aguilar-Londoño, Nicolás Coronel-Restrepo, Nicolás Coronel-Restrepo, Claudia Y. Monsalve-Arango, Claudia Y. Monsalve-Arango, Diana P. Cuesta-Castro, Alex Ramírez-Rincón, Alex Ramírez-Rincón   +10 more
doaj   +1 more source

Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system. [PDF]

, 2019
Vasoactive intestinal peptide (VIP), a gut peptide hormone originally reported as a vasodilator in 1970, has multiple physiological and pathological effects on development, growth, and the control of neuronal, epithelial, and endocrine cell functions ...
Akiba, Yasutada, Iwasaki, Mari, Kaunitz, Jonathan D   +2 more
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